Pulmonary Disease due to Mycobacterium tuberculosis in a Horse: Zoonotic Concerns and Limitations of Antemortem Testing
A case of pulmonary tuberculosis caused by Mycobacterium tuberculosis was diagnosed in a horse. Clinical evaluation performed prior to euthanasia did not suggest tuberculosis, but postmortem examination provided pathological and bacteriological evidence of mycobacteriosis. In the lungs, multiple tub...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Veterinary Medicine International |
| Online Access: | http://dx.doi.org/10.1155/2012/642145 |
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| author | Konstantin P. Lyashchenko Rena Greenwald Javan Esfandiari Alexis Lecu W. Ray Waters Horst Posthaus Thomas Bodmer Jean-Paul Janssens Fabio Aloisio Claudia Graubner Eléonore Grosclaude Alessandra Piersigilli Irene Schiller |
| author_facet | Konstantin P. Lyashchenko Rena Greenwald Javan Esfandiari Alexis Lecu W. Ray Waters Horst Posthaus Thomas Bodmer Jean-Paul Janssens Fabio Aloisio Claudia Graubner Eléonore Grosclaude Alessandra Piersigilli Irene Schiller |
| author_sort | Konstantin P. Lyashchenko |
| collection | DOAJ |
| description | A case of pulmonary tuberculosis caused by Mycobacterium tuberculosis was diagnosed in a horse. Clinical evaluation performed prior to euthanasia did not suggest tuberculosis, but postmortem examination provided pathological and bacteriological evidence of mycobacteriosis. In the lungs, multiple tuberculoid granulomas communicating with the bronchiolar lumen, pleural effusion, and a granulomatous lymphadenitis involving mediastinal and tracheobronchial lymph nodes were found. Serologic response to M. tuberculosis antigens was detected in the infected horse, but not in the group of 42 potentially exposed animals (18 horses, 14 alpacas, 6 donkeys, and 4 dogs) which showed no signs of disease. Diagnosis of tuberculosis in live horses remains extremely difficult. Four of 20 animal handlers at the farm were positive for tuberculous infection upon follow-up testing by interferon-gamma release assay, indicating a possibility of interspecies transmission of M. tuberculosis. |
| format | Article |
| id | doaj-art-a01828e00cfd4ca48c5f36cff1192971 |
| institution | Kabale University |
| issn | 2090-8113 2042-0048 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Veterinary Medicine International |
| spelling | doaj-art-a01828e00cfd4ca48c5f36cff11929712025-08-20T03:38:11ZengWileyVeterinary Medicine International2090-81132042-00482012-01-01201210.1155/2012/642145642145Pulmonary Disease due to Mycobacterium tuberculosis in a Horse: Zoonotic Concerns and Limitations of Antemortem TestingKonstantin P. Lyashchenko0Rena Greenwald1Javan Esfandiari2Alexis Lecu3W. Ray Waters4Horst Posthaus5Thomas Bodmer6Jean-Paul Janssens7Fabio Aloisio8Claudia Graubner9Eléonore Grosclaude10Alessandra Piersigilli11Irene Schiller12Research and Development Department, Chembio Diagnostic Systems, Inc., 3661 Horseblock Road, Medford, NY 11763, USAResearch and Development Department, Chembio Diagnostic Systems, Inc., 3661 Horseblock Road, Medford, NY 11763, USAResearch and Development Department, Chembio Diagnostic Systems, Inc., 3661 Horseblock Road, Medford, NY 11763, USAMuseum National d'Histoire Naturelle Department, Paris Zoo, 53 Avenue de Saint-Maurice, 75012 Paris, FranceInfectious Bacterial Diseases Research Unit, National Animal Disease Center, Ames, IA 50010, USAInstitute of Animal Pathology, Vetsuisse Faculty, University of Bern, P.O. Box 8466, 3001 Bern, SwitzerlandInstitute for Infectious Diseases, Medical Faculty, University of Bern, 3010 Bern, SwitzerlandDivision of Pulmonary Diseases, Geneva University Hospitals, 1211 Geneva, SwitzerlandInstitute of Animal Pathology, Vetsuisse Faculty, University of Bern, P.O. Box 8466, 3001 Bern, SwitzerlandEquine Clinic, Vetsuisse Faculty, University of Bern, P.O. Box 8466, 3001 Bern, SwitzerlandCantonal Veterinary Office Geneva, Quai Ernest-Ansermet 22, Plainpalais P.O. Box 76, 1211 Geneva 4, SwitzerlandInstitute of Animal Pathology, Vetsuisse Faculty, University of Bern, P.O. Box 8466, 3001 Bern, SwitzerlandMonitoring Department, Swiss Federal Veterinary Office, Schwarzenburgstrasse 155, 3003 Bern, SwitzerlandA case of pulmonary tuberculosis caused by Mycobacterium tuberculosis was diagnosed in a horse. Clinical evaluation performed prior to euthanasia did not suggest tuberculosis, but postmortem examination provided pathological and bacteriological evidence of mycobacteriosis. In the lungs, multiple tuberculoid granulomas communicating with the bronchiolar lumen, pleural effusion, and a granulomatous lymphadenitis involving mediastinal and tracheobronchial lymph nodes were found. Serologic response to M. tuberculosis antigens was detected in the infected horse, but not in the group of 42 potentially exposed animals (18 horses, 14 alpacas, 6 donkeys, and 4 dogs) which showed no signs of disease. Diagnosis of tuberculosis in live horses remains extremely difficult. Four of 20 animal handlers at the farm were positive for tuberculous infection upon follow-up testing by interferon-gamma release assay, indicating a possibility of interspecies transmission of M. tuberculosis.http://dx.doi.org/10.1155/2012/642145 |
| spellingShingle | Konstantin P. Lyashchenko Rena Greenwald Javan Esfandiari Alexis Lecu W. Ray Waters Horst Posthaus Thomas Bodmer Jean-Paul Janssens Fabio Aloisio Claudia Graubner Eléonore Grosclaude Alessandra Piersigilli Irene Schiller Pulmonary Disease due to Mycobacterium tuberculosis in a Horse: Zoonotic Concerns and Limitations of Antemortem Testing Veterinary Medicine International |
| title | Pulmonary Disease due to Mycobacterium tuberculosis in a Horse: Zoonotic Concerns and Limitations of Antemortem Testing |
| title_full | Pulmonary Disease due to Mycobacterium tuberculosis in a Horse: Zoonotic Concerns and Limitations of Antemortem Testing |
| title_fullStr | Pulmonary Disease due to Mycobacterium tuberculosis in a Horse: Zoonotic Concerns and Limitations of Antemortem Testing |
| title_full_unstemmed | Pulmonary Disease due to Mycobacterium tuberculosis in a Horse: Zoonotic Concerns and Limitations of Antemortem Testing |
| title_short | Pulmonary Disease due to Mycobacterium tuberculosis in a Horse: Zoonotic Concerns and Limitations of Antemortem Testing |
| title_sort | pulmonary disease due to mycobacterium tuberculosis in a horse zoonotic concerns and limitations of antemortem testing |
| url | http://dx.doi.org/10.1155/2012/642145 |
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