Gastric Cancer Actively Remodels Mechanical Microenvironment to Promote Chemotherapy Resistance via MSCs‐Mediated Mitochondrial Transfer

Gastric Cancer Actively Remodels Mechanical Microenvironment to Promote Chemotherapy Resistance via MSCs‐Mediated Mitochondrial Transfer

Abstract Chemotherapy resistance is the main reason of treatment failure in gastric cancer (GC). However, the mechanism of oxaliplatin (OXA) resistance remains unclear. Here, we demonstrate that extracellular mechanical signaling plays crucial roles in OXA resistance within GC. We selected OXA‐resis...

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Main Authors: Xin He, Li Zhong, Nan Wang, Baiwei Zhao, Yannan Wang, Xinxiang Wu, Changyu Zheng, Yueheng Ruan, Jianfeng Hou, Yusheng Luo, Yuehan Yin, Yulong He, Andy Peng Xiang, Jiancheng Wang
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Advanced Science
Subjects:
gastric cancer
matrix stiffness
oxaliplatin resistance
RhoA/ROCK1 signaling pathway
Online Access:https://doi.org/10.1002/advs.202404994
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