Impact of leukemia subtype and demographics on patient quality of life in 76 countries: a cross-sectional study
BackgroundDisease-specific factors associated with decreased quality of life (QoL) in patients with leukemia have not been studied in a large-scale, global, observational study.MethodsThis cross-sectional study used the validated Hematological Malignancy Patient Reported Outcomes (HM-PRO) questionna...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Hematology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/frhem.2024.1502166/full |
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| author | Sam Salek Samantha Nier Zack Pemberton-Whiteley Tatyana Ionova Giuseppe Ianni Giovanni Tripepi Nick York Nicole Schroeter Kathryn Huntley Michael Rynne Denis Costello Lidija Pecova Esther Natalie Oliva |
| author_facet | Sam Salek Samantha Nier Zack Pemberton-Whiteley Tatyana Ionova Giuseppe Ianni Giovanni Tripepi Nick York Nicole Schroeter Kathryn Huntley Michael Rynne Denis Costello Lidija Pecova Esther Natalie Oliva |
| author_sort | Sam Salek |
| collection | DOAJ |
| description | BackgroundDisease-specific factors associated with decreased quality of life (QoL) in patients with leukemia have not been studied in a large-scale, global, observational study.MethodsThis cross-sectional study used the validated Hematological Malignancy Patient Reported Outcomes (HM-PRO) questionnaire to assess the impact of leukemia subtype, age, sex, and years living with the disease on QoL of patients with leukemia.ResultsOverall, 2,628 patients responded: 45.7% had chronic lymphocytic leukemia (CLL), 34.0% had chronic myeloid leukemia (CML), 11.8% had acute myeloid leukemia (AML), and 3.5% had acute lymphoblastic leukemia (ALL). HM-PRO scores differed significantly between leukemia subtypes (p<0.001); patients with ALL reported the worst outcomes. Women had significantly worse scores than men (p<0.001). HM-PRO scores were inversely correlated both with age (ρ= –0.24, p<0.001) and years living with the disease (ρ= –0.14, p<0.001).ConclusionPatients reported the greatest concerns over their future treatment and future health, as well as concerns over dying and being a burden to others. Patients need access to support services, such as the availability of a clinical psychologist as part of the hematology team, to provide support with the emotional aspects of a leukemia diagnosis, especially for patients with acute leukemia subtypes reporting the lowest mean QoL scores. |
| format | Article |
| id | doaj-art-a0147a6f7c8240aa8fc3b9da15dcc3c1 |
| institution | Kabale University |
| issn | 2813-3935 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Hematology |
| spelling | doaj-art-a0147a6f7c8240aa8fc3b9da15dcc3c12025-01-23T15:03:13ZengFrontiers Media S.A.Frontiers in Hematology2813-39352025-01-01310.3389/frhem.2024.15021661502166Impact of leukemia subtype and demographics on patient quality of life in 76 countries: a cross-sectional studySam Salek0Samantha Nier1Zack Pemberton-Whiteley2Tatyana Ionova3Giuseppe Ianni4Giovanni Tripepi5Nick York6Nicole Schroeter7Kathryn Huntley8Michael Rynne9Denis Costello10Lidija Pecova11Esther Natalie Oliva12School of Life and Medical Sciences, University of Hertfordshire, Hatfield, United KingdomAcute Leukemia Advocates Network (ALAN), Leukemia Patient Advocates Foundation, Bern, SwitzerlandAcute Leukemia Advocates Network (ALAN), Leukemia Patient Advocates Foundation, Bern, SwitzerlandQuality of Life Monitoring Unit, Saint Petersburg State University Hospital, Saint Petersburg, RussiaDIELNET SrL, Reggio Calabria, ItalyIFC-CNR Institute of Clinical Physiology, Reggio Calabria, ItalyChronic Lymphocytic Leukaemia (CLL) Advocates Network, Leukemia Patient Advocates Foundation, Bern, SwitzerlandChronic Lymphocytic Leukaemia (CLL) Advocates Network, Leukemia Patient Advocates Foundation, Bern, SwitzerlandChronic Lymphocytic Leukaemia (CLL) Advocates Network, Leukemia Patient Advocates Foundation, Bern, SwitzerlandChronic Lymphocytic Leukaemia (CLL) Advocates Network, Leukemia Patient Advocates Foundation, Bern, SwitzerlandCML Advocates Network, Leukemia Patient Advocates Foundation, Bern, SwitzerlandCML Advocates Network, Leukemia Patient Advocates Foundation, Bern, SwitzerlandHematology Unit, Grande Ospedale Metropolitano Bianchi Melacrino Morelli, Reggio Calabria, ItalyBackgroundDisease-specific factors associated with decreased quality of life (QoL) in patients with leukemia have not been studied in a large-scale, global, observational study.MethodsThis cross-sectional study used the validated Hematological Malignancy Patient Reported Outcomes (HM-PRO) questionnaire to assess the impact of leukemia subtype, age, sex, and years living with the disease on QoL of patients with leukemia.ResultsOverall, 2,628 patients responded: 45.7% had chronic lymphocytic leukemia (CLL), 34.0% had chronic myeloid leukemia (CML), 11.8% had acute myeloid leukemia (AML), and 3.5% had acute lymphoblastic leukemia (ALL). HM-PRO scores differed significantly between leukemia subtypes (p<0.001); patients with ALL reported the worst outcomes. Women had significantly worse scores than men (p<0.001). HM-PRO scores were inversely correlated both with age (ρ= –0.24, p<0.001) and years living with the disease (ρ= –0.14, p<0.001).ConclusionPatients reported the greatest concerns over their future treatment and future health, as well as concerns over dying and being a burden to others. Patients need access to support services, such as the availability of a clinical psychologist as part of the hematology team, to provide support with the emotional aspects of a leukemia diagnosis, especially for patients with acute leukemia subtypes reporting the lowest mean QoL scores.https://www.frontiersin.org/articles/10.3389/frhem.2024.1502166/fullleukemiapatient-centered carepatient experiencepatient-reported outcomesquality of life |
| spellingShingle | Sam Salek Samantha Nier Zack Pemberton-Whiteley Tatyana Ionova Giuseppe Ianni Giovanni Tripepi Nick York Nicole Schroeter Kathryn Huntley Michael Rynne Denis Costello Lidija Pecova Esther Natalie Oliva Impact of leukemia subtype and demographics on patient quality of life in 76 countries: a cross-sectional study Frontiers in Hematology leukemia patient-centered care patient experience patient-reported outcomes quality of life |
| title | Impact of leukemia subtype and demographics on patient quality of life in 76 countries: a cross-sectional study |
| title_full | Impact of leukemia subtype and demographics on patient quality of life in 76 countries: a cross-sectional study |
| title_fullStr | Impact of leukemia subtype and demographics on patient quality of life in 76 countries: a cross-sectional study |
| title_full_unstemmed | Impact of leukemia subtype and demographics on patient quality of life in 76 countries: a cross-sectional study |
| title_short | Impact of leukemia subtype and demographics on patient quality of life in 76 countries: a cross-sectional study |
| title_sort | impact of leukemia subtype and demographics on patient quality of life in 76 countries a cross sectional study |
| topic | leukemia patient-centered care patient experience patient-reported outcomes quality of life |
| url | https://www.frontiersin.org/articles/10.3389/frhem.2024.1502166/full |
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