Impact of leukemia subtype and demographics on patient quality of life in 76 countries: a cross-sectional study

Impact of leukemia subtype and demographics on patient quality of life in 76 countries: a cross-sectional study

BackgroundDisease-specific factors associated with decreased quality of life (QoL) in patients with leukemia have not been studied in a large-scale, global, observational study.MethodsThis cross-sectional study used the validated Hematological Malignancy Patient Reported Outcomes (HM-PRO) questionna...

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Main Authors: Sam Salek, Samantha Nier, Zack Pemberton-Whiteley, Tatyana Ionova, Giuseppe Ianni, Giovanni Tripepi, Nick York, Nicole Schroeter, Kathryn Huntley, Michael Rynne, Denis Costello, Lidija Pecova, Esther Natalie Oliva
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Hematology
Subjects:
leukemia
patient-centered care
patient experience
patient-reported outcomes
quality of life
Online Access:https://www.frontiersin.org/articles/10.3389/frhem.2024.1502166/full
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Summary:BackgroundDisease-specific factors associated with decreased quality of life (QoL) in patients with leukemia have not been studied in a large-scale, global, observational study.MethodsThis cross-sectional study used the validated Hematological Malignancy Patient Reported Outcomes (HM-PRO) questionnaire to assess the impact of leukemia subtype, age, sex, and years living with the disease on QoL of patients with leukemia.ResultsOverall, 2,628 patients responded: 45.7% had chronic lymphocytic leukemia (CLL), 34.0% had chronic myeloid leukemia (CML), 11.8% had acute myeloid leukemia (AML), and 3.5% had acute lymphoblastic leukemia (ALL). HM-PRO scores differed significantly between leukemia subtypes (p<0.001); patients with ALL reported the worst outcomes. Women had significantly worse scores than men (p<0.001). HM-PRO scores were inversely correlated both with age (ρ= –0.24, p<0.001) and years living with the disease (ρ= –0.14, p<0.001).ConclusionPatients reported the greatest concerns over their future treatment and future health, as well as concerns over dying and being a burden to others. Patients need access to support services, such as the availability of a clinical psychologist as part of the hematology team, to provide support with the emotional aspects of a leukemia diagnosis, especially for patients with acute leukemia subtypes reporting the lowest mean QoL scores.
ISSN:2813-3935

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