Efficacy of Chinese Medicine on Postoperative Rehabilitation of Non-small Cell Lung Cancer (NSCLC), a Randomized Controlled Study
Background: With an increasing number of non-small cell lung cancer (NSCLC) patients being offered surgical treatment, postoperative rehabilitation is also being increasingly emphasized. Traditional Chinese medicine (TCM) holds promise for enhancing postoperative recovery, with treatment methods sti...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-01-01
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| Series: | Integrative Cancer Therapies |
| Online Access: | https://doi.org/10.1177/15347354251314529 |
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| author | Yifeng Gu MD Yichao Wang MD Huiling Zhou MD Ao Qi PhD Guanjin Wu MM Jiaqi Li MMed Congmeng Zhang MMed Yong Yang MD Jialin Yao MD Wenxiao Yang PhD Lingzi Su MMed Yi Liu MMed Xueqi Tian MMed Jiajun Song MMed Yabin Gong MD Xiong Qin MD Lijing Jiao PhD Ling Xu PhD |
| author_facet | Yifeng Gu MD Yichao Wang MD Huiling Zhou MD Ao Qi PhD Guanjin Wu MM Jiaqi Li MMed Congmeng Zhang MMed Yong Yang MD Jialin Yao MD Wenxiao Yang PhD Lingzi Su MMed Yi Liu MMed Xueqi Tian MMed Jiajun Song MMed Yabin Gong MD Xiong Qin MD Lijing Jiao PhD Ling Xu PhD |
| author_sort | Yifeng Gu MD |
| collection | DOAJ |
| description | Background: With an increasing number of non-small cell lung cancer (NSCLC) patients being offered surgical treatment, postoperative rehabilitation is also being increasingly emphasized. Traditional Chinese medicine (TCM) holds promise for enhancing postoperative recovery, with treatment methods still in refinement. This study aims to evaluate the efficacy of Chinese herbal decoction and Liuzijue exercises in NSCLC patients during the rapid postoperative recovery period. Methods: A randomized, parallel-group clinical trial assigned 50 patients to receive Chinese herbal medicine and Liuzijue exercise plus symptomatic treatment, and 49 to symptomatic treatment alone. Treatment continued until postoperative complications resolved, chest tubes were removed, and no abnormal examination findings were reported. The primary outcome was Quality of Life Questionnare-Core 30 (QLQ-C30) score. Secondary outcomes included MOS item short form 36-Item Short Form Health Survey (SF-36) score, rate of complications, six-minute walk test (6MWT) distance, Leicester Cough Questionnaire (LCQ) score, numerical rating scale (NRS) score, and functional activity score (FAS). Results: Significant improvements in role (MD: 12.15, 95%CI: 2.99-21.32, P < .05) and social functioning (MD: 10.25, 95%CI: 1.72-18.78, P < .05) were observed in the intervention group vs. controls, as measured by QLQ-C30. The intervention group showed better post-treatment SF-36 scores in Role-Physical (RP), Social Function (SF), Role-Emotional (RE), and Mental Health Summary (MCS) ( P < .05). The complication rate was lower in the intervention (20.00%) than the control group (44.44%) ( P < .05). The intervention group also had a significant increase in FAS scores ( P < .05) and covered a better 6MWT distance ( P < .05). Conclusion: Chinese herbal decoction and Liuzijue exercises during the rapid recovery period after lung cancer surgery enhanced patients’ QoL and physical endurance, and mitigated complications. Trial registration: This tial was registered with chictr.org.cn (Registration number:ChiCTR2100044776). |
| format | Article |
| id | doaj-art-a00b603f697944c79aeed8696ab7a7ee |
| institution | Kabale University |
| issn | 1552-695X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Integrative Cancer Therapies |
| spelling | doaj-art-a00b603f697944c79aeed8696ab7a7ee2025-02-07T06:03:42ZengSAGE PublishingIntegrative Cancer Therapies1552-695X2025-01-012410.1177/15347354251314529Efficacy of Chinese Medicine on Postoperative Rehabilitation of Non-small Cell Lung Cancer (NSCLC), a Randomized Controlled StudyYifeng Gu MD0Yichao Wang MD1Huiling Zhou MD2Ao Qi PhD3Guanjin Wu MM4Jiaqi Li MMed5Congmeng Zhang MMed6Yong Yang MD7Jialin Yao MD8Wenxiao Yang PhD9Lingzi Su MMed10Yi Liu MMed11Xueqi Tian MMed12Jiajun Song MMed13Yabin Gong MD14Xiong Qin MD15Lijing Jiao PhD16Ling Xu PhD17Yueyang Hospital of Integrated Traditional Chinese Medicine and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaYueyang Hospital of Integrated Traditional Chinese Medicine and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaYueyang Hospital of Integrated Traditional Chinese Medicine and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaYueyang Hospital of Integrated Traditional Chinese Medicine and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaYueyang Hospital of Integrated Traditional Chinese Medicine and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaYueyang Hospital of Integrated Traditional Chinese Medicine and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaFangta T.C.M. Hospital of Songjiang District Shanghai, Shanghai, ChinaShanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, ChinaYueyang Hospital of Integrated Traditional Chinese Medicine and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaYueyang Hospital of Integrated Traditional Chinese Medicine and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaYueyang Hospital of Integrated Traditional Chinese Medicine and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaYueyang Hospital of Integrated Traditional Chinese Medicine and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaYueyang Hospital of Integrated Traditional Chinese Medicine and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaYueyang Hospital of Integrated Traditional Chinese Medicine and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaYueyang Hospital of Integrated Traditional Chinese Medicine and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaShanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, ChinaYueyang Hospital of Integrated Traditional Chinese Medicine and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaYueyang Hospital of Integrated Traditional Chinese Medicine and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaBackground: With an increasing number of non-small cell lung cancer (NSCLC) patients being offered surgical treatment, postoperative rehabilitation is also being increasingly emphasized. Traditional Chinese medicine (TCM) holds promise for enhancing postoperative recovery, with treatment methods still in refinement. This study aims to evaluate the efficacy of Chinese herbal decoction and Liuzijue exercises in NSCLC patients during the rapid postoperative recovery period. Methods: A randomized, parallel-group clinical trial assigned 50 patients to receive Chinese herbal medicine and Liuzijue exercise plus symptomatic treatment, and 49 to symptomatic treatment alone. Treatment continued until postoperative complications resolved, chest tubes were removed, and no abnormal examination findings were reported. The primary outcome was Quality of Life Questionnare-Core 30 (QLQ-C30) score. Secondary outcomes included MOS item short form 36-Item Short Form Health Survey (SF-36) score, rate of complications, six-minute walk test (6MWT) distance, Leicester Cough Questionnaire (LCQ) score, numerical rating scale (NRS) score, and functional activity score (FAS). Results: Significant improvements in role (MD: 12.15, 95%CI: 2.99-21.32, P < .05) and social functioning (MD: 10.25, 95%CI: 1.72-18.78, P < .05) were observed in the intervention group vs. controls, as measured by QLQ-C30. The intervention group showed better post-treatment SF-36 scores in Role-Physical (RP), Social Function (SF), Role-Emotional (RE), and Mental Health Summary (MCS) ( P < .05). The complication rate was lower in the intervention (20.00%) than the control group (44.44%) ( P < .05). The intervention group also had a significant increase in FAS scores ( P < .05) and covered a better 6MWT distance ( P < .05). Conclusion: Chinese herbal decoction and Liuzijue exercises during the rapid recovery period after lung cancer surgery enhanced patients’ QoL and physical endurance, and mitigated complications. Trial registration: This tial was registered with chictr.org.cn (Registration number:ChiCTR2100044776).https://doi.org/10.1177/15347354251314529 |
| spellingShingle | Yifeng Gu MD Yichao Wang MD Huiling Zhou MD Ao Qi PhD Guanjin Wu MM Jiaqi Li MMed Congmeng Zhang MMed Yong Yang MD Jialin Yao MD Wenxiao Yang PhD Lingzi Su MMed Yi Liu MMed Xueqi Tian MMed Jiajun Song MMed Yabin Gong MD Xiong Qin MD Lijing Jiao PhD Ling Xu PhD Efficacy of Chinese Medicine on Postoperative Rehabilitation of Non-small Cell Lung Cancer (NSCLC), a Randomized Controlled Study Integrative Cancer Therapies |
| title | Efficacy of Chinese Medicine on Postoperative Rehabilitation of Non-small Cell Lung Cancer (NSCLC), a Randomized Controlled Study |
| title_full | Efficacy of Chinese Medicine on Postoperative Rehabilitation of Non-small Cell Lung Cancer (NSCLC), a Randomized Controlled Study |
| title_fullStr | Efficacy of Chinese Medicine on Postoperative Rehabilitation of Non-small Cell Lung Cancer (NSCLC), a Randomized Controlled Study |
| title_full_unstemmed | Efficacy of Chinese Medicine on Postoperative Rehabilitation of Non-small Cell Lung Cancer (NSCLC), a Randomized Controlled Study |
| title_short | Efficacy of Chinese Medicine on Postoperative Rehabilitation of Non-small Cell Lung Cancer (NSCLC), a Randomized Controlled Study |
| title_sort | efficacy of chinese medicine on postoperative rehabilitation of non small cell lung cancer nsclc a randomized controlled study |
| url | https://doi.org/10.1177/15347354251314529 |
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