Pattern of bone marrow involvement by solid tumors: Experience from a tertiary care center from South India
Background: Bone marrow involvement by solid tumor implicates advanced disease and dismal prognosis. Bone marrow aspiration and biopsy are routinely performed as staging workup for certain small round cell tumors and also for unexplained cytopenia in other solid tumors. It is important to rule out b...
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| Format: | Article |
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2019-01-01
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| Series: | Indian Journal of Medical and Paediatric Oncology |
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| Online Access: | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2019;volume=40;issue=5;spage=99;epage=101;aulast=Rudresha |
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| author | A H Rudresha Rajesh Patidar Kuntegowdanahalli C Lakshmaiah K Govind Babu Dasappa Lokanatha Linu Abraham Jacob M C Suresh Babu N R Namrata N Lokesh Kadabur L K Rajeev Abhishek Anand Vikas Asati |
| author_facet | A H Rudresha Rajesh Patidar Kuntegowdanahalli C Lakshmaiah K Govind Babu Dasappa Lokanatha Linu Abraham Jacob M C Suresh Babu N R Namrata N Lokesh Kadabur L K Rajeev Abhishek Anand Vikas Asati |
| author_sort | A H Rudresha |
| collection | DOAJ |
| description | Background: Bone marrow involvement by solid tumor implicates advanced disease and dismal prognosis. Bone marrow aspiration and biopsy are routinely performed as staging workup for certain small round cell tumors and also for unexplained cytopenia in other solid tumors. It is important to rule out bone marrow involvement before planning for curative treatment. Materials and Methods: This was a retrospective observational study. The aim of our study was to evaluate the pattern of bone marrow involvement by different solid tumors and their correlation with the hematological abnormalities. We retrospectively evaluated bone marrow aspirations and biopsy performed in past 3 years. Results: At our institution, bone marrow examinations were performed in 440 patients during past 3 years for solid malignancies. Out of 440, 206 were pediatric cases and 234 were adult cases. Bone marrow was involved in 56 (12.7%) patients. Among the pediatric cases, bone marrow involvement was present in 30 (12.8%) cases, and in adult cases, bone marrow was involved was in 26 (11.1%) cases. Neuroblastoma (40%) was the most common malignancy, which involved the bone marrow among pediatric cases, followed by retinoblastoma (26.6%) and Ewing's sarcoma (20%). Among adult patients, neuroendocrine carcinoma (23%) was at the top of the list of tumors involving bone marrow, which is followed by Ewing's sarcoma (19.2%) and nasopharyngeal carcinoma (11.5%). Conclusion: Neuroblastoma and neuroendocrine carcinoma are the major cause of bone marrow involvement among the solid malignancies in pediatric and adult population, respectively. Use of immunohistochemistry markers on bone marrow biopsies may result in higher detection rate. |
| format | Article |
| id | doaj-art-a00adf7ce590400f9d9787ad92bef5b4 |
| institution | DOAJ |
| issn | 0971-5851 0975-2129 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Indian Journal of Medical and Paediatric Oncology |
| spelling | doaj-art-a00adf7ce590400f9d9787ad92bef5b42025-08-20T03:16:43ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Medical and Paediatric Oncology0971-58510975-21292019-01-014059910110.4103/ijmpo.ijmpo_170_17Pattern of bone marrow involvement by solid tumors: Experience from a tertiary care center from South IndiaA H RudreshaRajesh PatidarKuntegowdanahalli C LakshmaiahK Govind BabuDasappa LokanathaLinu Abraham JacobM C Suresh BabuN R NamrataN Lokesh KadaburL K RajeevAbhishek AnandVikas AsatiBackground: Bone marrow involvement by solid tumor implicates advanced disease and dismal prognosis. Bone marrow aspiration and biopsy are routinely performed as staging workup for certain small round cell tumors and also for unexplained cytopenia in other solid tumors. It is important to rule out bone marrow involvement before planning for curative treatment. Materials and Methods: This was a retrospective observational study. The aim of our study was to evaluate the pattern of bone marrow involvement by different solid tumors and their correlation with the hematological abnormalities. We retrospectively evaluated bone marrow aspirations and biopsy performed in past 3 years. Results: At our institution, bone marrow examinations were performed in 440 patients during past 3 years for solid malignancies. Out of 440, 206 were pediatric cases and 234 were adult cases. Bone marrow was involved in 56 (12.7%) patients. Among the pediatric cases, bone marrow involvement was present in 30 (12.8%) cases, and in adult cases, bone marrow was involved was in 26 (11.1%) cases. Neuroblastoma (40%) was the most common malignancy, which involved the bone marrow among pediatric cases, followed by retinoblastoma (26.6%) and Ewing's sarcoma (20%). Among adult patients, neuroendocrine carcinoma (23%) was at the top of the list of tumors involving bone marrow, which is followed by Ewing's sarcoma (19.2%) and nasopharyngeal carcinoma (11.5%). Conclusion: Neuroblastoma and neuroendocrine carcinoma are the major cause of bone marrow involvement among the solid malignancies in pediatric and adult population, respectively. Use of immunohistochemistry markers on bone marrow biopsies may result in higher detection rate.http://www.ijmpo.org/article.asp?issn=0971-5851;year=2019;volume=40;issue=5;spage=99;epage=101;aulast=RudreshaBone marrow and solid tumormetastasis to bone marrowpattern of bone marrow involvement |
| spellingShingle | A H Rudresha Rajesh Patidar Kuntegowdanahalli C Lakshmaiah K Govind Babu Dasappa Lokanatha Linu Abraham Jacob M C Suresh Babu N R Namrata N Lokesh Kadabur L K Rajeev Abhishek Anand Vikas Asati Pattern of bone marrow involvement by solid tumors: Experience from a tertiary care center from South India Indian Journal of Medical and Paediatric Oncology Bone marrow and solid tumor metastasis to bone marrow pattern of bone marrow involvement |
| title | Pattern of bone marrow involvement by solid tumors: Experience from a tertiary care center from South India |
| title_full | Pattern of bone marrow involvement by solid tumors: Experience from a tertiary care center from South India |
| title_fullStr | Pattern of bone marrow involvement by solid tumors: Experience from a tertiary care center from South India |
| title_full_unstemmed | Pattern of bone marrow involvement by solid tumors: Experience from a tertiary care center from South India |
| title_short | Pattern of bone marrow involvement by solid tumors: Experience from a tertiary care center from South India |
| title_sort | pattern of bone marrow involvement by solid tumors experience from a tertiary care center from south india |
| topic | Bone marrow and solid tumor metastasis to bone marrow pattern of bone marrow involvement |
| url | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2019;volume=40;issue=5;spage=99;epage=101;aulast=Rudresha |
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