A case of infectious mononucleosis caused by Epstein-Barr virus complicated by autoimmune hemolytic anemia
We represent a rare clinical case of infectious mononucleosis with hepatitis, caused by Epstein-Barr virus, complicated by rare secondary autoimmune hemolytic anemia associated with warm agglutinins in a 16-year-old patient. The disease was long-lasting, with a two-wave course of febrile fever. Sign...
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| Format: | Article |
| Language: | Russian |
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LLC "Diagnostics and Vaccines"
2024-06-01
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| Series: | Детские инфекции (Москва) |
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| Online Access: | https://detinf.elpub.ru/jour/article/view/950 |
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| author | R. F. Sayfullin K. E. Abdieva A. V. Razumeykina A. P. Zolotareva O. A. Ivanova |
| author_facet | R. F. Sayfullin K. E. Abdieva A. V. Razumeykina A. P. Zolotareva O. A. Ivanova |
| author_sort | R. F. Sayfullin |
| collection | DOAJ |
| description | We represent a rare clinical case of infectious mononucleosis with hepatitis, caused by Epstein-Barr virus, complicated by rare secondary autoimmune hemolytic anemia associated with warm agglutinins in a 16-year-old patient. The disease was long-lasting, with a two-wave course of febrile fever. Signs of hepatitis with the development of anemia of moderate severity appeared during the second wave of febrile fever. The etiology of the disease was confirmed by the detection of Epstein-Barr virus DNA in blood and the detection of anti-VCA IgM antibodies to Epstein-Barr virus in the absence of anti-EBNA IgG antibodies. Hemolytic anemia was verified using markers of hemolysis (increased lactate dehydrogenase activity, decreased haptoglobin concentration), and positive results of a direct Coombs test. After successful initiation of prednisone therapy and clinical improvement, the patient was discharged from the hospital on the 24th day of disease to continue treatment on an outpatient basis (prednisone was replaced by methylprednisolone).This case demonstrates the development of a rare autoimmune complication in infectious mononucleosis caused by the Epstein-Barr virus. |
| format | Article |
| id | doaj-art-a009bb7a43b549ed82dd2e419425fcf0 |
| institution | DOAJ |
| issn | 2072-8107 |
| language | Russian |
| publishDate | 2024-06-01 |
| publisher | LLC "Diagnostics and Vaccines" |
| record_format | Article |
| series | Детские инфекции (Москва) |
| spelling | doaj-art-a009bb7a43b549ed82dd2e419425fcf02025-08-20T03:15:20ZrusLLC "Diagnostics and Vaccines"Детские инфекции (Москва)2072-81072024-06-01232556010.22627/2072-8107-2024-23-2-55-60666A case of infectious mononucleosis caused by Epstein-Barr virus complicated by autoimmune hemolytic anemiaR. F. Sayfullin0K. E. Abdieva1A. V. Razumeykina2A. P. Zolotareva3O. A. Ivanova4Pirogov Russian National Research Medical UniversityPirogov Russian National Research Medical UniversityPirogov Russian National Research Medical UniversityPirogov Russian National Research Medical UniversityInfectious Clinical Hospital No. 1We represent a rare clinical case of infectious mononucleosis with hepatitis, caused by Epstein-Barr virus, complicated by rare secondary autoimmune hemolytic anemia associated with warm agglutinins in a 16-year-old patient. The disease was long-lasting, with a two-wave course of febrile fever. Signs of hepatitis with the development of anemia of moderate severity appeared during the second wave of febrile fever. The etiology of the disease was confirmed by the detection of Epstein-Barr virus DNA in blood and the detection of anti-VCA IgM antibodies to Epstein-Barr virus in the absence of anti-EBNA IgG antibodies. Hemolytic anemia was verified using markers of hemolysis (increased lactate dehydrogenase activity, decreased haptoglobin concentration), and positive results of a direct Coombs test. After successful initiation of prednisone therapy and clinical improvement, the patient was discharged from the hospital on the 24th day of disease to continue treatment on an outpatient basis (prednisone was replaced by methylprednisolone).This case demonstrates the development of a rare autoimmune complication in infectious mononucleosis caused by the Epstein-Barr virus.https://detinf.elpub.ru/jour/article/view/950infectious mononucleosisepstein-barr viruscomplicationsautoimmune hemolytic anemia |
| spellingShingle | R. F. Sayfullin K. E. Abdieva A. V. Razumeykina A. P. Zolotareva O. A. Ivanova A case of infectious mononucleosis caused by Epstein-Barr virus complicated by autoimmune hemolytic anemia Детские инфекции (Москва) infectious mononucleosis epstein-barr virus complications autoimmune hemolytic anemia |
| title | A case of infectious mononucleosis caused by Epstein-Barr virus complicated by autoimmune hemolytic anemia |
| title_full | A case of infectious mononucleosis caused by Epstein-Barr virus complicated by autoimmune hemolytic anemia |
| title_fullStr | A case of infectious mononucleosis caused by Epstein-Barr virus complicated by autoimmune hemolytic anemia |
| title_full_unstemmed | A case of infectious mononucleosis caused by Epstein-Barr virus complicated by autoimmune hemolytic anemia |
| title_short | A case of infectious mononucleosis caused by Epstein-Barr virus complicated by autoimmune hemolytic anemia |
| title_sort | case of infectious mononucleosis caused by epstein barr virus complicated by autoimmune hemolytic anemia |
| topic | infectious mononucleosis epstein-barr virus complications autoimmune hemolytic anemia |
| url | https://detinf.elpub.ru/jour/article/view/950 |
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