5‐HT6 receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia

5‐HT6 receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia

Abstract Cognitive deficits in schizophrenia severely compromise quality of life and are poorly controlled by current antipsychotics. While 5‐HT6 receptor blockade holds special promise, molecular substrates underlying their control of cognition remain unclear. Using a proteomic strategy, we show th...

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Main Authors: Julie Meffre, Séverine Chaumont‐Dubel, Clotilde Mannoury la Cour, Florence Loiseau, David J. G. Watson, Anne Dekeyne, Martial Séveno, Jean‐Michel Rivet, Florence Gaven, Paul Déléris, Denis Hervé, Kevin C. F. Fone, Joël Bockaert, Mark J. Millan, Philippe Marin
Format: Article
Language:English
Published: Springer Nature 2012-10-01
Series:EMBO Molecular Medicine
Subjects:
5‐HT6 receptor
cognition
mTORC1
proteomics
schizophrenia
Online Access:https://doi.org/10.1002/emmm.201201410
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