Vitamin B6 Neonatal Toxicity
Vitamin B6 is a micronutrient required by the body. It acts as a coenzyme in biochemical reactions. Vitamin B6 toxicity is not caused by the intake of food-based sources. The few reported cases of vitamin B6 toxicity are always caused by overdosing of nutritional supplements. Chronic toxicity typica...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Case Reports in Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2022/3171351 |
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| author | Andrea Guala Giulia Folgori Micaela Silvestri Michelangelo Barbaglia Cesare Danesino |
| author_facet | Andrea Guala Giulia Folgori Micaela Silvestri Michelangelo Barbaglia Cesare Danesino |
| author_sort | Andrea Guala |
| collection | DOAJ |
| description | Vitamin B6 is a micronutrient required by the body. It acts as a coenzyme in biochemical reactions. Vitamin B6 toxicity is not caused by the intake of food-based sources. The few reported cases of vitamin B6 toxicity are always caused by overdosing of nutritional supplements. Chronic toxicity typically occurs with peripheral neuropathy such as paraesthesia, ataxia, and imbalance, paradoxically mimicking vitamin B6 deficiency. However, the prognosis is favorable, and symptoms usually show improvement once excessive vitamin B6 levels return to the physiological range. We report a newborn presenting with diffuse tremor at birth, interpreted as secondary to the mother's intake of high doses of a supplement containing vitamin B6 during pregnancy and breastfeeding. As expected, the newborn’s serum levels of vitamin B6 were high. The tremors disappeared when the maternal supplement was stopped. |
| format | Article |
| id | doaj-art-a0065bc9b654493a982bd25656993a3a |
| institution | OA Journals |
| issn | 2090-6811 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pediatrics |
| spelling | doaj-art-a0065bc9b654493a982bd25656993a3a2025-08-20T02:23:04ZengWileyCase Reports in Pediatrics2090-68112022-01-01202210.1155/2022/3171351Vitamin B6 Neonatal ToxicityAndrea Guala0Giulia Folgori1Micaela Silvestri2Michelangelo Barbaglia3Cesare Danesino4SOC PediatricsSOC PediatricsSOC PediatricsSOC PediatricsDepartment of Molecular MedicineVitamin B6 is a micronutrient required by the body. It acts as a coenzyme in biochemical reactions. Vitamin B6 toxicity is not caused by the intake of food-based sources. The few reported cases of vitamin B6 toxicity are always caused by overdosing of nutritional supplements. Chronic toxicity typically occurs with peripheral neuropathy such as paraesthesia, ataxia, and imbalance, paradoxically mimicking vitamin B6 deficiency. However, the prognosis is favorable, and symptoms usually show improvement once excessive vitamin B6 levels return to the physiological range. We report a newborn presenting with diffuse tremor at birth, interpreted as secondary to the mother's intake of high doses of a supplement containing vitamin B6 during pregnancy and breastfeeding. As expected, the newborn’s serum levels of vitamin B6 were high. The tremors disappeared when the maternal supplement was stopped.http://dx.doi.org/10.1155/2022/3171351 |
| spellingShingle | Andrea Guala Giulia Folgori Micaela Silvestri Michelangelo Barbaglia Cesare Danesino Vitamin B6 Neonatal Toxicity Case Reports in Pediatrics |
| title | Vitamin B6 Neonatal Toxicity |
| title_full | Vitamin B6 Neonatal Toxicity |
| title_fullStr | Vitamin B6 Neonatal Toxicity |
| title_full_unstemmed | Vitamin B6 Neonatal Toxicity |
| title_short | Vitamin B6 Neonatal Toxicity |
| title_sort | vitamin b6 neonatal toxicity |
| url | http://dx.doi.org/10.1155/2022/3171351 |
| work_keys_str_mv | AT andreaguala vitaminb6neonataltoxicity AT giuliafolgori vitaminb6neonataltoxicity AT micaelasilvestri vitaminb6neonataltoxicity AT michelangelobarbaglia vitaminb6neonataltoxicity AT cesaredanesino vitaminb6neonataltoxicity |