SARS-CoV-2 vaccine-elicited immune responses in solid organ transplant recipients
Solid organ transplant recipients (SOTRs) are considered a high-risk group for coronavirus disease 2019 (COVID-19). The adaptive immune responses generated by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination include humoral and cellular immune responses. Most studies on the S...
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| Format: | Article |
| Language: | English |
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The Korean Society for Transplantation
2024-12-01
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| Series: | Clinical Transplantation and Research |
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| Online Access: | https://www.ctrjournal.org/journal/view.html?doi=10.4285/ctr.24.0062 |
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| _version_ | 1841531268438687744 |
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| author | Euri Seo Eui-Cheol Shin Min Kyung Jung |
| author_facet | Euri Seo Eui-Cheol Shin Min Kyung Jung |
| author_sort | Euri Seo |
| collection | DOAJ |
| description | Solid organ transplant recipients (SOTRs) are considered a high-risk group for coronavirus disease 2019 (COVID-19). The adaptive immune responses generated by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination include humoral and cellular immune responses. Most studies on the SARS-CoV-2 vaccine have focused primarily on humoral immunity, but cellular immunity is vital for effectively controlling progression to severe COVID-19. In SOTRs, the vaccine-induced adaptive immune response is significantly attenuated compared to the response in healthy individuals. Nevertheless, vaccinated SOTRs exhibit a reduced rate and severity of SARS-CoV-2 infection. This review aims to provide a concise overview of the current understanding of SARS-CoV-2 vaccine-induced immune responses in SOTRs. |
| format | Article |
| id | doaj-art-a002e785ddab477086dd22365f8240d9 |
| institution | Kabale University |
| issn | 3022-6783 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | The Korean Society for Transplantation |
| record_format | Article |
| series | Clinical Transplantation and Research |
| spelling | doaj-art-a002e785ddab477086dd22365f8240d92025-01-15T02:51:59ZengThe Korean Society for TransplantationClinical Transplantation and Research3022-67832024-12-0138424725610.4285/ctr.24.0062ctr.24.0062SARS-CoV-2 vaccine-elicited immune responses in solid organ transplant recipientsEuri Seo0Eui-Cheol Shin1Min Kyung Jung2The Center for Viral Immunology, Korea Virus Research Institute, Institute for Basic Science (IBS), Daejeon, KoreaThe Center for Viral Immunology, Korea Virus Research Institute, Institute for Basic Science (IBS), Daejeon, KoreaThe Center for Viral Immunology, Korea Virus Research Institute, Institute for Basic Science (IBS), Daejeon, KoreaSolid organ transplant recipients (SOTRs) are considered a high-risk group for coronavirus disease 2019 (COVID-19). The adaptive immune responses generated by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination include humoral and cellular immune responses. Most studies on the SARS-CoV-2 vaccine have focused primarily on humoral immunity, but cellular immunity is vital for effectively controlling progression to severe COVID-19. In SOTRs, the vaccine-induced adaptive immune response is significantly attenuated compared to the response in healthy individuals. Nevertheless, vaccinated SOTRs exhibit a reduced rate and severity of SARS-CoV-2 infection. This review aims to provide a concise overview of the current understanding of SARS-CoV-2 vaccine-induced immune responses in SOTRs.https://www.ctrjournal.org/journal/view.html?doi=10.4285/ctr.24.0062solid organ transplant recipients; sars-cov-2 vaccine; humoral immune responses; cellular immune responses |
| spellingShingle | Euri Seo Eui-Cheol Shin Min Kyung Jung SARS-CoV-2 vaccine-elicited immune responses in solid organ transplant recipients Clinical Transplantation and Research solid organ transplant recipients; sars-cov-2 vaccine; humoral immune responses; cellular immune responses |
| title | SARS-CoV-2 vaccine-elicited immune responses in solid organ transplant recipients |
| title_full | SARS-CoV-2 vaccine-elicited immune responses in solid organ transplant recipients |
| title_fullStr | SARS-CoV-2 vaccine-elicited immune responses in solid organ transplant recipients |
| title_full_unstemmed | SARS-CoV-2 vaccine-elicited immune responses in solid organ transplant recipients |
| title_short | SARS-CoV-2 vaccine-elicited immune responses in solid organ transplant recipients |
| title_sort | sars cov 2 vaccine elicited immune responses in solid organ transplant recipients |
| topic | solid organ transplant recipients; sars-cov-2 vaccine; humoral immune responses; cellular immune responses |
| url | https://www.ctrjournal.org/journal/view.html?doi=10.4285/ctr.24.0062 |
| work_keys_str_mv | AT euriseo sarscov2vaccineelicitedimmuneresponsesinsolidorgantransplantrecipients AT euicheolshin sarscov2vaccineelicitedimmuneresponsesinsolidorgantransplantrecipients AT minkyungjung sarscov2vaccineelicitedimmuneresponsesinsolidorgantransplantrecipients |