Multifunctional nitrogen-sulfur codoped carbon quantum dots: Determining reduced glutathione, broad-spectrum antibacterial activity, and cell imaging
In this study, nitrogen-sulfur codoped carbon quantum dots (N-S/CQDs) with various functions and properties were synthesized through a one-step method utilizing citric acid and cysteine as reaction substrates. The fluorescence of N-S/CQDs can be specifically quenched by permanganate ion (MnO4−), and...
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| Language: | English |
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Elsevier
2024-10-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024142089 |
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| author | Zhipeng Ruan Zhifeng Xu Tianhui Liu Liwen Chen Xiaoling Liu Kaiying Chen Chengfei Zhao |
| author_facet | Zhipeng Ruan Zhifeng Xu Tianhui Liu Liwen Chen Xiaoling Liu Kaiying Chen Chengfei Zhao |
| author_sort | Zhipeng Ruan |
| collection | DOAJ |
| description | In this study, nitrogen-sulfur codoped carbon quantum dots (N-S/CQDs) with various functions and properties were synthesized through a one-step method utilizing citric acid and cysteine as reaction substrates. The fluorescence of N-S/CQDs can be specifically quenched by permanganate ion (MnO4−), and the quenched fluorescence can be recovered by the presence of reduced glutathione (GSH). A fluorescence sensing system based on N-S/CQDs@MnO4− was developed and successfully applied for the determination of GSH in pharmaceutical preparations. Additionally, N-S/CQDs demonstrated broad-spectrum antibacterial activity, with minimum inhibitory concentrations of 32 μg/ml against Staphylococcus aureus (gram-positive bacterium) and 64 μg/ml against Escherichia coli (gram-negative bacterium). N-S/CQDs also proved effective for cell imaging, exhibiting excellent biocompatibility. These findings underscore the multifunctional characteristics and promising application potential of N-S/CQDs. Furthermore, this study provides a solid foundation for the development of multifunctional carbon quantum dots and the expansion of their applications in various fields. |
| format | Article |
| id | doaj-art-9ffe2956cba34b82808da44e61b8c48e |
| institution | OA Journals |
| issn | 2405-8440 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-9ffe2956cba34b82808da44e61b8c48e2025-08-20T01:54:45ZengElsevierHeliyon2405-84402024-10-011019e3817710.1016/j.heliyon.2024.e38177Multifunctional nitrogen-sulfur codoped carbon quantum dots: Determining reduced glutathione, broad-spectrum antibacterial activity, and cell imagingZhipeng Ruan0Zhifeng Xu1Tianhui Liu2Liwen Chen3Xiaoling Liu4Kaiying Chen5Chengfei Zhao6Department of Pharmacy, School of Pharmacy and Medical Technology, Putian University, Putian, 351100, China; Key Laboratory of Pharmaceutical Analysis and Laboratory Medicine (Putian University), Fujian Province University, Putian, 351100, ChinaDepartment of Cardiothoracic Surgery, Affiliated Hospital of Putian University, Putian University, Putian, 351100, ChinaDepartment of Pharmacy, School of Pharmacy and Medical Technology, Putian University, Putian, 351100, China; Key Laboratory of Pharmaceutical Analysis and Laboratory Medicine (Putian University), Fujian Province University, Putian, 351100, ChinaDepartment of Pharmacy, School of Pharmacy and Medical Technology, Putian University, Putian, 351100, ChinaDepartment of Pharmacy, School of Pharmacy and Medical Technology, Putian University, Putian, 351100, ChinaPathology Department, The First Hospital of Putian City, Putian, 351100, ChinaDepartment of Pharmacy, School of Pharmacy and Medical Technology, Putian University, Putian, 351100, China; Key Laboratory of Pharmaceutical Analysis and Laboratory Medicine (Putian University), Fujian Province University, Putian, 351100, China; Corresponding author. Department of Pharmacy, School of Pharmacy and Medical Technology, Putian University, 1133 Xueyuan Road, Chengxiang District, Putian, 351100, China.In this study, nitrogen-sulfur codoped carbon quantum dots (N-S/CQDs) with various functions and properties were synthesized through a one-step method utilizing citric acid and cysteine as reaction substrates. The fluorescence of N-S/CQDs can be specifically quenched by permanganate ion (MnO4−), and the quenched fluorescence can be recovered by the presence of reduced glutathione (GSH). A fluorescence sensing system based on N-S/CQDs@MnO4− was developed and successfully applied for the determination of GSH in pharmaceutical preparations. Additionally, N-S/CQDs demonstrated broad-spectrum antibacterial activity, with minimum inhibitory concentrations of 32 μg/ml against Staphylococcus aureus (gram-positive bacterium) and 64 μg/ml against Escherichia coli (gram-negative bacterium). N-S/CQDs also proved effective for cell imaging, exhibiting excellent biocompatibility. These findings underscore the multifunctional characteristics and promising application potential of N-S/CQDs. Furthermore, this study provides a solid foundation for the development of multifunctional carbon quantum dots and the expansion of their applications in various fields.http://www.sciencedirect.com/science/article/pii/S2405844024142089Antibacterial activityBiocompatibilityCarbon quantum dotsCell imagingFluorescence sensingReduced glutathione |
| spellingShingle | Zhipeng Ruan Zhifeng Xu Tianhui Liu Liwen Chen Xiaoling Liu Kaiying Chen Chengfei Zhao Multifunctional nitrogen-sulfur codoped carbon quantum dots: Determining reduced glutathione, broad-spectrum antibacterial activity, and cell imaging Heliyon Antibacterial activity Biocompatibility Carbon quantum dots Cell imaging Fluorescence sensing Reduced glutathione |
| title | Multifunctional nitrogen-sulfur codoped carbon quantum dots: Determining reduced glutathione, broad-spectrum antibacterial activity, and cell imaging |
| title_full | Multifunctional nitrogen-sulfur codoped carbon quantum dots: Determining reduced glutathione, broad-spectrum antibacterial activity, and cell imaging |
| title_fullStr | Multifunctional nitrogen-sulfur codoped carbon quantum dots: Determining reduced glutathione, broad-spectrum antibacterial activity, and cell imaging |
| title_full_unstemmed | Multifunctional nitrogen-sulfur codoped carbon quantum dots: Determining reduced glutathione, broad-spectrum antibacterial activity, and cell imaging |
| title_short | Multifunctional nitrogen-sulfur codoped carbon quantum dots: Determining reduced glutathione, broad-spectrum antibacterial activity, and cell imaging |
| title_sort | multifunctional nitrogen sulfur codoped carbon quantum dots determining reduced glutathione broad spectrum antibacterial activity and cell imaging |
| topic | Antibacterial activity Biocompatibility Carbon quantum dots Cell imaging Fluorescence sensing Reduced glutathione |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024142089 |
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