Nanoparticulate Copper Cluster-Mediated Biosensing of Cardiac Biomolecular Markers
Being a leading cause of death, heart diseases across the globe need special attention to enable early diagnosis. Metal nanoparticle-mediated biosensors are useful clinical tools for the early detection of bio-analytes. The size-dependent surface plasmon resonance (SPR) of metal nanoparticles can be...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-04-01
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| Series: | Biosensors |
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| Online Access: | https://www.mdpi.com/2079-6374/15/4/237 |
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| _version_ | 1850144657970823168 |
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| author | Lakshmi V. Nair Jarred Wheeler Yaelyn Ha Kimberly M. Jones Jesse Jones Vinoy Thomas |
| author_facet | Lakshmi V. Nair Jarred Wheeler Yaelyn Ha Kimberly M. Jones Jesse Jones Vinoy Thomas |
| author_sort | Lakshmi V. Nair |
| collection | DOAJ |
| description | Being a leading cause of death, heart diseases across the globe need special attention to enable early diagnosis. Metal nanoparticle-mediated biosensors are useful clinical tools for the early detection of bio-analytes. The size-dependent surface plasmon resonance (SPR) of metal nanoparticles can be effectively utilized for the same purpose. The early detection of heart diseases can be evaluated by monitoring the troponin level. A copper nanoparticle-mediated troponin biosensor was developed through antibody conjugation for troponin I and troponin T. The copper nanosensor shows a concentration-dependent SPR change towards troponin T and troponin I. |
| format | Article |
| id | doaj-art-9ffcd8a5f86e475f923be71f702f6243 |
| institution | OA Journals |
| issn | 2079-6374 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj-art-9ffcd8a5f86e475f923be71f702f62432025-08-20T02:28:18ZengMDPI AGBiosensors2079-63742025-04-0115423710.3390/bios15040237Nanoparticulate Copper Cluster-Mediated Biosensing of Cardiac Biomolecular MarkersLakshmi V. Nair0Jarred Wheeler1Yaelyn Ha2Kimberly M. Jones3Jesse Jones4Vinoy Thomas5Department of Mechanical and Materials Engineering, School of Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USADepartment of Mechanical and Materials Engineering, School of Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USADepartment of Mechanical and Materials Engineering, School of Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USADepartment of Mechanical and Materials Engineering, School of Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USADepartment of Neurosurgery, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USADepartment of Mechanical and Materials Engineering, School of Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USABeing a leading cause of death, heart diseases across the globe need special attention to enable early diagnosis. Metal nanoparticle-mediated biosensors are useful clinical tools for the early detection of bio-analytes. The size-dependent surface plasmon resonance (SPR) of metal nanoparticles can be effectively utilized for the same purpose. The early detection of heart diseases can be evaluated by monitoring the troponin level. A copper nanoparticle-mediated troponin biosensor was developed through antibody conjugation for troponin I and troponin T. The copper nanosensor shows a concentration-dependent SPR change towards troponin T and troponin I.https://www.mdpi.com/2079-6374/15/4/237biosensorcoppertroponincardiac biomarker |
| spellingShingle | Lakshmi V. Nair Jarred Wheeler Yaelyn Ha Kimberly M. Jones Jesse Jones Vinoy Thomas Nanoparticulate Copper Cluster-Mediated Biosensing of Cardiac Biomolecular Markers Biosensors biosensor copper troponin cardiac biomarker |
| title | Nanoparticulate Copper Cluster-Mediated Biosensing of Cardiac Biomolecular Markers |
| title_full | Nanoparticulate Copper Cluster-Mediated Biosensing of Cardiac Biomolecular Markers |
| title_fullStr | Nanoparticulate Copper Cluster-Mediated Biosensing of Cardiac Biomolecular Markers |
| title_full_unstemmed | Nanoparticulate Copper Cluster-Mediated Biosensing of Cardiac Biomolecular Markers |
| title_short | Nanoparticulate Copper Cluster-Mediated Biosensing of Cardiac Biomolecular Markers |
| title_sort | nanoparticulate copper cluster mediated biosensing of cardiac biomolecular markers |
| topic | biosensor copper troponin cardiac biomarker |
| url | https://www.mdpi.com/2079-6374/15/4/237 |
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