Association of genetic variations in ACE2, TIRAP and factor X with outcomes in COVID-19.
<h4>Background</h4>Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can manifest with varying disease severity and mortality. Genetic predisposition influences the clinical course of infectious diseases. We investigated whet...
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0260897&type=printable |
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| author | Marissa J M Traets Roel H T Nijhuis Servaas A Morré Sander Ouburg Jasper A Remijn Bastiaan A Blok Bas de Laat Eefje Jong Gerarda J M Herder Aernoud T L Fiolet Stephan P Verweij |
| author_facet | Marissa J M Traets Roel H T Nijhuis Servaas A Morré Sander Ouburg Jasper A Remijn Bastiaan A Blok Bas de Laat Eefje Jong Gerarda J M Herder Aernoud T L Fiolet Stephan P Verweij |
| author_sort | Marissa J M Traets |
| collection | DOAJ |
| description | <h4>Background</h4>Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can manifest with varying disease severity and mortality. Genetic predisposition influences the clinical course of infectious diseases. We investigated whether genetic polymorphisms in candidate genes ACE2, TIRAP, and factor X are associated with clinical outcomes in COVID-19.<h4>Methods</h4>We conducted a single-centre retrospective cohort study. All patients who visited the emergency department with SARS-CoV-2 infection proven by polymerase chain reaction were included. Single nucleotide polymorphisms in ACE2 (rs2285666), TIRAP (rs8177374) and factor X (rs3211783) were assessed. The outcomes were mortality, respiratory failure and venous thromboembolism. Respiratory failure was defined as the necessity of >5 litres/minute oxygen, high flow nasal oxygen suppletion or mechanical ventilation.<h4>Results</h4>Between March and April 2020, 116 patients (35% female, median age 65 [inter quartile range 55-75] years) were included and treated according to the then applicable guidelines. Sixteen patients (14%) died, 44 patients (38%) had respiratory failure of whom 23 required endotracheal intubation for mechanical ventilation, and 20 patients (17%) developed venous thromboembolism. The percentage of TIRAP polymorphism carriers in the survivor group was 28% as compared to 0% in the non-survivor group (p = 0.01, Bonferroni corrected p = 0.02). Genotype distribution of ACE2 and factor X did not differ between survivors and non-survivors.<h4>Conclusion</h4>This study shows that carriage of TIRAP polymorphism rs8177374 could be associated with a significantly lower mortality in COVID-19. This TIRAP polymorphism may be an important predictor in the outcome of COVID-19. |
| format | Article |
| id | doaj-art-9ff676f3f6e247ae8c2c86fc093dd3c4 |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-9ff676f3f6e247ae8c2c86fc093dd3c42025-08-20T02:46:28ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01171e026089710.1371/journal.pone.0260897Association of genetic variations in ACE2, TIRAP and factor X with outcomes in COVID-19.Marissa J M TraetsRoel H T NijhuisServaas A MorréSander OuburgJasper A RemijnBastiaan A BlokBas de LaatEefje JongGerarda J M HerderAernoud T L FioletStephan P Verweij<h4>Background</h4>Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can manifest with varying disease severity and mortality. Genetic predisposition influences the clinical course of infectious diseases. We investigated whether genetic polymorphisms in candidate genes ACE2, TIRAP, and factor X are associated with clinical outcomes in COVID-19.<h4>Methods</h4>We conducted a single-centre retrospective cohort study. All patients who visited the emergency department with SARS-CoV-2 infection proven by polymerase chain reaction were included. Single nucleotide polymorphisms in ACE2 (rs2285666), TIRAP (rs8177374) and factor X (rs3211783) were assessed. The outcomes were mortality, respiratory failure and venous thromboembolism. Respiratory failure was defined as the necessity of >5 litres/minute oxygen, high flow nasal oxygen suppletion or mechanical ventilation.<h4>Results</h4>Between March and April 2020, 116 patients (35% female, median age 65 [inter quartile range 55-75] years) were included and treated according to the then applicable guidelines. Sixteen patients (14%) died, 44 patients (38%) had respiratory failure of whom 23 required endotracheal intubation for mechanical ventilation, and 20 patients (17%) developed venous thromboembolism. The percentage of TIRAP polymorphism carriers in the survivor group was 28% as compared to 0% in the non-survivor group (p = 0.01, Bonferroni corrected p = 0.02). Genotype distribution of ACE2 and factor X did not differ between survivors and non-survivors.<h4>Conclusion</h4>This study shows that carriage of TIRAP polymorphism rs8177374 could be associated with a significantly lower mortality in COVID-19. This TIRAP polymorphism may be an important predictor in the outcome of COVID-19.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0260897&type=printable |
| spellingShingle | Marissa J M Traets Roel H T Nijhuis Servaas A Morré Sander Ouburg Jasper A Remijn Bastiaan A Blok Bas de Laat Eefje Jong Gerarda J M Herder Aernoud T L Fiolet Stephan P Verweij Association of genetic variations in ACE2, TIRAP and factor X with outcomes in COVID-19. PLoS ONE |
| title | Association of genetic variations in ACE2, TIRAP and factor X with outcomes in COVID-19. |
| title_full | Association of genetic variations in ACE2, TIRAP and factor X with outcomes in COVID-19. |
| title_fullStr | Association of genetic variations in ACE2, TIRAP and factor X with outcomes in COVID-19. |
| title_full_unstemmed | Association of genetic variations in ACE2, TIRAP and factor X with outcomes in COVID-19. |
| title_short | Association of genetic variations in ACE2, TIRAP and factor X with outcomes in COVID-19. |
| title_sort | association of genetic variations in ace2 tirap and factor x with outcomes in covid 19 |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0260897&type=printable |
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