Hepatitis B surface antigen hijacks TANK-binding kinase 1 to suppress type I interferon and induce early autophagy

Hepatitis B surface antigen hijacks TANK-binding kinase 1 to suppress type I interferon and induce early autophagy

Abstract There are close links between innate immunity and autophagy. However, the crosstalk between innate immunity and autophagy in host cells infected with hepatitis B virus (HBV) remains unclear. Here, we reported that HBsAg suppressed type I interferon production and induced the accumulation of...

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Main Authors: Chuanjin Luo, Caijiao Ma, Gang Xu, Chengbo Lu, June Ma, Yu Huang, Longyu Nie, Chen Yu, Yongfang Xia, Zhiqiang Liu, Ying Zhu, Shi Liu
Format: Article
Language:English
Published: Nature Publishing Group 2025-04-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07605-0
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