Optimization of selectively chloroacetic acid esterification in the presence of Amberlyst-15 catalyst using the response surface methodology
This research seeks to develop a sustainable and effective approach to the synthesis of the α-halocarboxylic acid ester derivatives. Using Amberlyst-15, as a heterogeneous acid catalyst, the reaction between various alcohols and chloroacetic acid has been successfully facilitated. In contrast to com...
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| Language: | English |
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Elsevier
2025-03-01
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| Series: | Results in Chemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715625001304 |
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| author | Ahmad Nikseresht Seyyed Hossein Hosseini Leila Matin Hamid Reza Azizi |
| author_facet | Ahmad Nikseresht Seyyed Hossein Hosseini Leila Matin Hamid Reza Azizi |
| author_sort | Ahmad Nikseresht |
| collection | DOAJ |
| description | This research seeks to develop a sustainable and effective approach to the synthesis of the α-halocarboxylic acid ester derivatives. Using Amberlyst-15, as a heterogeneous acid catalyst, the reaction between various alcohols and chloroacetic acid has been successfully facilitated. In contrast to common optimization procedures, the response surface methodology (RSM) was employed to optimize the reaction conditions, ensuring maximum yield and selectivity. First, several factors including temperature, time, catalyst loading, and acid-to-alcohol ratio were identified to establish the required minimum number of experiments, followed by their execution in the laboratory. Finally, RSM was applied to investigate and optimize the system based on the experimental data. Notably, all materials utilized in this study are widely accessible, which renders this approach highly practical and scalable. The environmentally friendly and sustainable nature of the suggested method, coupled with optimized reaction conditions, renders it a desirable option for producing ester derivatives. |
| format | Article |
| id | doaj-art-9fee3072d9ab4a099877dcd89b21bb49 |
| institution | OA Journals |
| issn | 2211-7156 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Chemistry |
| spelling | doaj-art-9fee3072d9ab4a099877dcd89b21bb492025-08-20T02:04:38ZengElsevierResults in Chemistry2211-71562025-03-011410214710.1016/j.rechem.2025.102147Optimization of selectively chloroacetic acid esterification in the presence of Amberlyst-15 catalyst using the response surface methodologyAhmad Nikseresht0Seyyed Hossein Hosseini1Leila Matin2Hamid Reza Azizi3Department of Chemistry, Payame Noor University, PO BOX 19395-4697, Tehran, Iran; Corresponding authors.Department of Chemical Engineering, Ilam University, 69315-516 Ilam, Iran; Corresponding authors.Department of Chemistry, Payame Noor University, PO BOX 19395-4697, Tehran, IranDepartment of Chemical Engineering, Ilam University, 69315-516 Ilam, IranThis research seeks to develop a sustainable and effective approach to the synthesis of the α-halocarboxylic acid ester derivatives. Using Amberlyst-15, as a heterogeneous acid catalyst, the reaction between various alcohols and chloroacetic acid has been successfully facilitated. In contrast to common optimization procedures, the response surface methodology (RSM) was employed to optimize the reaction conditions, ensuring maximum yield and selectivity. First, several factors including temperature, time, catalyst loading, and acid-to-alcohol ratio were identified to establish the required minimum number of experiments, followed by their execution in the laboratory. Finally, RSM was applied to investigate and optimize the system based on the experimental data. Notably, all materials utilized in this study are widely accessible, which renders this approach highly practical and scalable. The environmentally friendly and sustainable nature of the suggested method, coupled with optimized reaction conditions, renders it a desirable option for producing ester derivatives.http://www.sciencedirect.com/science/article/pii/S2211715625001304Chloroacetic acidAlcoholEsterificationAmberlyst-15Response surface methodology (RSM) |
| spellingShingle | Ahmad Nikseresht Seyyed Hossein Hosseini Leila Matin Hamid Reza Azizi Optimization of selectively chloroacetic acid esterification in the presence of Amberlyst-15 catalyst using the response surface methodology Results in Chemistry Chloroacetic acid Alcohol Esterification Amberlyst-15 Response surface methodology (RSM) |
| title | Optimization of selectively chloroacetic acid esterification in the presence of Amberlyst-15 catalyst using the response surface methodology |
| title_full | Optimization of selectively chloroacetic acid esterification in the presence of Amberlyst-15 catalyst using the response surface methodology |
| title_fullStr | Optimization of selectively chloroacetic acid esterification in the presence of Amberlyst-15 catalyst using the response surface methodology |
| title_full_unstemmed | Optimization of selectively chloroacetic acid esterification in the presence of Amberlyst-15 catalyst using the response surface methodology |
| title_short | Optimization of selectively chloroacetic acid esterification in the presence of Amberlyst-15 catalyst using the response surface methodology |
| title_sort | optimization of selectively chloroacetic acid esterification in the presence of amberlyst 15 catalyst using the response surface methodology |
| topic | Chloroacetic acid Alcohol Esterification Amberlyst-15 Response surface methodology (RSM) |
| url | http://www.sciencedirect.com/science/article/pii/S2211715625001304 |
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