Impact of body mass index on clinical presentation and prognosis in myasthenia gravis
Abstract Background The literature lacks consistent information on the correlation between baseline body mass index (BMI), clinical presentation, and prognosis in patients with myasthenia gravis (MG). This observational multicenter prospective cohort study included patients with MG from February 201...
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| Language: | English |
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BMC
2025-07-01
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| Series: | Orphanet Journal of Rare Diseases |
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| Online Access: | https://doi.org/10.1186/s13023-025-03902-1 |
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| author | Hong-xi Chen Zi-ya Wang Na-na Zhang Xue Lin Zi-yan Shi Xiao-fei Wang Ying Zhang Qin Du Ling-yao Kong Dong-ren Sun Rui Wang Yang-yang Zhang Shuang-jie Li Yu-wei Da Hui-yu Feng Hong-yu Zhou |
| author_facet | Hong-xi Chen Zi-ya Wang Na-na Zhang Xue Lin Zi-yan Shi Xiao-fei Wang Ying Zhang Qin Du Ling-yao Kong Dong-ren Sun Rui Wang Yang-yang Zhang Shuang-jie Li Yu-wei Da Hui-yu Feng Hong-yu Zhou |
| author_sort | Hong-xi Chen |
| collection | DOAJ |
| description | Abstract Background The literature lacks consistent information on the correlation between baseline body mass index (BMI), clinical presentation, and prognosis in patients with myasthenia gravis (MG). This observational multicenter prospective cohort study included patients with MG from February 2017 to June 2023, categorizing them by baseline BMI. The primary outcome was the time to generalization of ocular MG. Secondary outcomes included the time to Activities of Daily Living (ADL) response and Minimal Symptom Expression (MSE). Kaplan-Meier curves and multivariable Cox proportional hazards regression models were used to assess the impact of BMI on these outcomes. Results Out of 940 MG patients (510 women) included, 524 had a low BMI and 416 had a high BMI, with a median age of 50.00 years. Patients in the high BMI group were significantly older (p < 0.001), had a lower percentage of females (p < 0.001), and had a shorter disease duration (p = 0.014) compared to those with a low BMI. They also had higher rates of ocular onset (p < 0.001), ocular MG classification (p = 0.001), and acetylcholine receptor antibody seropositivity (p = 0.007), but a lower incidence of thymectomy (p = 0.027). During a median follow-up of 33.00 months, the adjusted Cox models revealed that a higher baseline BMI was associated with an increased risk of ocular MG generalization (HR 1.06; 95% CI 1.01–1.11; p = 0.026), but not with ADL response (HR 0.99; 95% CI 0.95–1.04; p = 0.779) or MSE (HR 0.97; 95% CI 0.92–1.02; p = 0.240). Conclusions A higher baseline BMI was associated with an increased risk of ocular MG generalization but not with ADL response or MSE. |
| format | Article |
| id | doaj-art-9fecbb9c519e472b94b04c9dfdb39cc5 |
| institution | Kabale University |
| issn | 1750-1172 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Orphanet Journal of Rare Diseases |
| spelling | doaj-art-9fecbb9c519e472b94b04c9dfdb39cc52025-08-20T03:42:07ZengBMCOrphanet Journal of Rare Diseases1750-11722025-07-012011710.1186/s13023-025-03902-1Impact of body mass index on clinical presentation and prognosis in myasthenia gravisHong-xi Chen0Zi-ya Wang1Na-na Zhang2Xue Lin3Zi-yan Shi4Xiao-fei Wang5Ying Zhang6Qin Du7Ling-yao Kong8Dong-ren Sun9Rui Wang10Yang-yang Zhang11Shuang-jie Li12Yu-wei Da13Hui-yu Feng14Hong-yu Zhou15Department of Neurology, West China Hospital, Sichuan UniversityDepartment of Neurology, West China Hospital, Sichuan UniversityDepartment of Neurology, West China Hospital, Sichuan UniversityDepartment of Neurology, West China Hospital, Sichuan UniversityDepartment of Neurology, West China Hospital, Sichuan UniversityDepartment of Neurology, West China Hospital, Sichuan UniversityDepartment of Neurology, West China Hospital, Sichuan UniversityDepartment of Neurology, West China Hospital, Sichuan UniversityDepartment of Neurology, West China Hospital, Sichuan UniversityDepartment of Neurology, West China Hospital, Sichuan UniversityDepartment of Neurology, West China Hospital, Sichuan UniversityDepartment of Neurology, West China Hospital, Sichuan UniversityDepartment of Neurology, West China Hospital, Sichuan UniversityDepartment of Neurology, Xuanwu Hospital, Capital Medical UniversityDepartment of Neurology, The First Affiliated Hospital, Sun Yat-sen UniversityDepartment of Neurology, West China Hospital, Sichuan UniversityAbstract Background The literature lacks consistent information on the correlation between baseline body mass index (BMI), clinical presentation, and prognosis in patients with myasthenia gravis (MG). This observational multicenter prospective cohort study included patients with MG from February 2017 to June 2023, categorizing them by baseline BMI. The primary outcome was the time to generalization of ocular MG. Secondary outcomes included the time to Activities of Daily Living (ADL) response and Minimal Symptom Expression (MSE). Kaplan-Meier curves and multivariable Cox proportional hazards regression models were used to assess the impact of BMI on these outcomes. Results Out of 940 MG patients (510 women) included, 524 had a low BMI and 416 had a high BMI, with a median age of 50.00 years. Patients in the high BMI group were significantly older (p < 0.001), had a lower percentage of females (p < 0.001), and had a shorter disease duration (p = 0.014) compared to those with a low BMI. They also had higher rates of ocular onset (p < 0.001), ocular MG classification (p = 0.001), and acetylcholine receptor antibody seropositivity (p = 0.007), but a lower incidence of thymectomy (p = 0.027). During a median follow-up of 33.00 months, the adjusted Cox models revealed that a higher baseline BMI was associated with an increased risk of ocular MG generalization (HR 1.06; 95% CI 1.01–1.11; p = 0.026), but not with ADL response (HR 0.99; 95% CI 0.95–1.04; p = 0.779) or MSE (HR 0.97; 95% CI 0.92–1.02; p = 0.240). Conclusions A higher baseline BMI was associated with an increased risk of ocular MG generalization but not with ADL response or MSE.https://doi.org/10.1186/s13023-025-03902-1Body mass indexMyasthenia GravisGeneralization of ocular myasthenia GravisActivities of daily living responseMinimal symptom expression |
| spellingShingle | Hong-xi Chen Zi-ya Wang Na-na Zhang Xue Lin Zi-yan Shi Xiao-fei Wang Ying Zhang Qin Du Ling-yao Kong Dong-ren Sun Rui Wang Yang-yang Zhang Shuang-jie Li Yu-wei Da Hui-yu Feng Hong-yu Zhou Impact of body mass index on clinical presentation and prognosis in myasthenia gravis Orphanet Journal of Rare Diseases Body mass index Myasthenia Gravis Generalization of ocular myasthenia Gravis Activities of daily living response Minimal symptom expression |
| title | Impact of body mass index on clinical presentation and prognosis in myasthenia gravis |
| title_full | Impact of body mass index on clinical presentation and prognosis in myasthenia gravis |
| title_fullStr | Impact of body mass index on clinical presentation and prognosis in myasthenia gravis |
| title_full_unstemmed | Impact of body mass index on clinical presentation and prognosis in myasthenia gravis |
| title_short | Impact of body mass index on clinical presentation and prognosis in myasthenia gravis |
| title_sort | impact of body mass index on clinical presentation and prognosis in myasthenia gravis |
| topic | Body mass index Myasthenia Gravis Generalization of ocular myasthenia Gravis Activities of daily living response Minimal symptom expression |
| url | https://doi.org/10.1186/s13023-025-03902-1 |
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