Levels of different cytokines in women and men with asymptomatic genital infection caused by Chlamydia
Introduction: Immune response to genital Chlamydia trachomatis infection is involved in both immunity and pathology. The cytokine profile during infection has been implicated in the disease outcome, either resolution or severe sequelae. Methodology: In total, 3900 patients were analyzed for pres...
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The Journal of Infection in Developing Countries
2019-09-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/9810 |
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| author | Alessandra Bua Sara Cannas Stefania Zanetti Paola Molicotti |
| author_facet | Alessandra Bua Sara Cannas Stefania Zanetti Paola Molicotti |
| author_sort | Alessandra Bua |
| collection | DOAJ |
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Introduction: Immune response to genital Chlamydia trachomatis infection is involved in both immunity and pathology. The cytokine profile during infection has been implicated in the disease outcome, either resolution or severe sequelae.
Methodology: In total, 3900 patients were analyzed for presence of genital infections caused by Chlamydia using molecular assays. Interleukins (IL) IL-10, IL-17, IL-6, IL-2 and chemokine IP-10 were estimated by ELISA in urine, cervical swabs and semen samples. Statistical analysis was performed using the T student test.
Results: A total of 47 out of 3900 samples (1.2%) were found to be positive for Chlamydia trachomatis based on the Real Time (RT) PCR results. Statistical analysis revealed that the differences between Chlamydia trachomatis positive and negative samples regarding levels of cytokines were not significant.
Conclusions: Our results demonstrated that no significant difference in cytokine concentrations exists in Chlamydia trachomatis infected patients when compared to healthy controls. In further study, we aim to test on a greater number of positive samples a greater number of cytokines involved in the immune response to Chlamydia trachomatis infections.
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| format | Article |
| id | doaj-art-9fec29dd3a864b22ae07127a2f39b987 |
| institution | Kabale University |
| issn | 1972-2680 |
| language | English |
| publishDate | 2019-09-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-9fec29dd3a864b22ae07127a2f39b9872025-08-20T03:52:43ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802019-09-01130910.3855/jidc.9810Levels of different cytokines in women and men with asymptomatic genital infection caused by ChlamydiaAlessandra Bua0Sara Cannas1Stefania Zanetti2Paola Molicotti3Department of Biomedical Sciences, Section of Experimental and Clinical Microbiology, University of Sassari, Sassari, ItalyDepartment of Biomedical Sciences, Section of Experimental and Clinical Microbiology, University of Sassari, Sassari, ItalyDepartment of Biomedical Sciences, Section of Experimental and Clinical Microbiology, University of Sassari, Sassari, ItalyDepartment of Biomedical Sciences, Section of Experimental and Clinical Microbiology, University of Sassari, Sassari, Italy Introduction: Immune response to genital Chlamydia trachomatis infection is involved in both immunity and pathology. The cytokine profile during infection has been implicated in the disease outcome, either resolution or severe sequelae. Methodology: In total, 3900 patients were analyzed for presence of genital infections caused by Chlamydia using molecular assays. Interleukins (IL) IL-10, IL-17, IL-6, IL-2 and chemokine IP-10 were estimated by ELISA in urine, cervical swabs and semen samples. Statistical analysis was performed using the T student test. Results: A total of 47 out of 3900 samples (1.2%) were found to be positive for Chlamydia trachomatis based on the Real Time (RT) PCR results. Statistical analysis revealed that the differences between Chlamydia trachomatis positive and negative samples regarding levels of cytokines were not significant. Conclusions: Our results demonstrated that no significant difference in cytokine concentrations exists in Chlamydia trachomatis infected patients when compared to healthy controls. In further study, we aim to test on a greater number of positive samples a greater number of cytokines involved in the immune response to Chlamydia trachomatis infections. https://jidc.org/index.php/journal/article/view/9810infectionChlamydiainterleukin-10interleukin-17cytokine |
| spellingShingle | Alessandra Bua Sara Cannas Stefania Zanetti Paola Molicotti Levels of different cytokines in women and men with asymptomatic genital infection caused by Chlamydia Journal of Infection in Developing Countries infection Chlamydia interleukin-10 interleukin-17 cytokine |
| title | Levels of different cytokines in women and men with asymptomatic genital infection caused by Chlamydia |
| title_full | Levels of different cytokines in women and men with asymptomatic genital infection caused by Chlamydia |
| title_fullStr | Levels of different cytokines in women and men with asymptomatic genital infection caused by Chlamydia |
| title_full_unstemmed | Levels of different cytokines in women and men with asymptomatic genital infection caused by Chlamydia |
| title_short | Levels of different cytokines in women and men with asymptomatic genital infection caused by Chlamydia |
| title_sort | levels of different cytokines in women and men with asymptomatic genital infection caused by chlamydia |
| topic | infection Chlamydia interleukin-10 interleukin-17 cytokine |
| url | https://jidc.org/index.php/journal/article/view/9810 |
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