Effects of pantogam active on behavior and neuroreceptor spectrum in mouse model of attention deficit disorder
Effect of Pantogam active subchronic administration (200 mg/kg/day, i.p.) on the behavior of outbred CD-1 mice in the experimental model of attention deficit disorder was studied in the "closed enriched cross maze" test. Pantogam active corrected the initial attention deficit of ED-low rod...
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| Format: | Article |
| Language: | Russian |
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LLC “Publisher OKI”
2022-07-01
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| Series: | Фармакокинетика и Фармакодинамика |
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| Online Access: | https://www.pharmacokinetica.ru/jour/article/view/315 |
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| author | N. A. Sukhorukova E. V. Vasileva E. A. Kondrakhin R. M. Salimov G. I. Kovalev |
| author_facet | N. A. Sukhorukova E. V. Vasileva E. A. Kondrakhin R. M. Salimov G. I. Kovalev |
| author_sort | N. A. Sukhorukova |
| collection | DOAJ |
| description | Effect of Pantogam active subchronic administration (200 mg/kg/day, i.p.) on the behavior of outbred CD-1 mice in the experimental model of attention deficit disorder was studied in the "closed enriched cross maze" test. Pantogam active corrected the initial attention deficit of ED-low rodents subpopulation without changing other parameters of their behavior. Analysis of the results of radioligand binding revealed statistically significant differences in the distribution of D2 and GABAB-receptors in the brain structures of outbred CD-1 mice subpopulations. In the prefrontal cortex (PFC) of ED-low control group with reduced attention level, compared with ED-high control, density of D2 receptors was higher by 18 %, while density of GABAB receptors was lower by 35 %. Administration of pantogam active resulted in decreasing of D2 receptors density by 23 % and increasing of this indicator by 42 % for GABAB- receptors in the PFC of ED-low animals, respectively. Thus, this studied drug has potential efficacy in treating attention deficit in experimental animals, normalizes behavior and possible molecular markers of this pathology. |
| format | Article |
| id | doaj-art-9feb8249b1df4ea985fe39d2ebae4d74 |
| institution | Kabale University |
| issn | 2587-7836 2686-8830 |
| language | Russian |
| publishDate | 2022-07-01 |
| publisher | LLC “Publisher OKI” |
| record_format | Article |
| series | Фармакокинетика и Фармакодинамика |
| spelling | doaj-art-9feb8249b1df4ea985fe39d2ebae4d742025-08-20T03:57:48ZrusLLC “Publisher OKI”Фармакокинетика и Фармакодинамика2587-78362686-88302022-07-0102233010.37489/2587-7836-2022-2-23-30301Effects of pantogam active on behavior and neuroreceptor spectrum in mouse model of attention deficit disorderN. A. Sukhorukova0E. V. Vasileva1E. A. Kondrakhin2R. M. Salimov3G. I. Kovalev4FSBI “Zakusov Institute of Pharmacology”FSBI “Zakusov Institute of Pharmacology”FSBI “Zakusov Institute of Pharmacology”FSBI “Zakusov Institute of Pharmacology”FSBI “Zakusov Institute of Pharmacology”Effect of Pantogam active subchronic administration (200 mg/kg/day, i.p.) on the behavior of outbred CD-1 mice in the experimental model of attention deficit disorder was studied in the "closed enriched cross maze" test. Pantogam active corrected the initial attention deficit of ED-low rodents subpopulation without changing other parameters of their behavior. Analysis of the results of radioligand binding revealed statistically significant differences in the distribution of D2 and GABAB-receptors in the brain structures of outbred CD-1 mice subpopulations. In the prefrontal cortex (PFC) of ED-low control group with reduced attention level, compared with ED-high control, density of D2 receptors was higher by 18 %, while density of GABAB receptors was lower by 35 %. Administration of pantogam active resulted in decreasing of D2 receptors density by 23 % and increasing of this indicator by 42 % for GABAB- receptors in the PFC of ED-low animals, respectively. Thus, this studied drug has potential efficacy in treating attention deficit in experimental animals, normalizes behavior and possible molecular markers of this pathology.https://www.pharmacokinetica.ru/jour/article/view/315attention deficit disorderpantogam activeclosed enriched cross mazeradioligand bindingd<sub>2</sub> receptorgaba<sub>b</sub>-receptornmda receptorexploratory behaviorprefrontal cortex |
| spellingShingle | N. A. Sukhorukova E. V. Vasileva E. A. Kondrakhin R. M. Salimov G. I. Kovalev Effects of pantogam active on behavior and neuroreceptor spectrum in mouse model of attention deficit disorder Фармакокинетика и Фармакодинамика attention deficit disorder pantogam active closed enriched cross maze radioligand binding d<sub>2</sub> receptor gaba<sub>b</sub>-receptor nmda receptor exploratory behavior prefrontal cortex |
| title | Effects of pantogam active on behavior and neuroreceptor spectrum in mouse model of attention deficit disorder |
| title_full | Effects of pantogam active on behavior and neuroreceptor spectrum in mouse model of attention deficit disorder |
| title_fullStr | Effects of pantogam active on behavior and neuroreceptor spectrum in mouse model of attention deficit disorder |
| title_full_unstemmed | Effects of pantogam active on behavior and neuroreceptor spectrum in mouse model of attention deficit disorder |
| title_short | Effects of pantogam active on behavior and neuroreceptor spectrum in mouse model of attention deficit disorder |
| title_sort | effects of pantogam active on behavior and neuroreceptor spectrum in mouse model of attention deficit disorder |
| topic | attention deficit disorder pantogam active closed enriched cross maze radioligand binding d<sub>2</sub> receptor gaba<sub>b</sub>-receptor nmda receptor exploratory behavior prefrontal cortex |
| url | https://www.pharmacokinetica.ru/jour/article/view/315 |
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