Pharmacokinetics and Pharmacodynamics of Rusfertide, a Hepcidin Mimetic, Following Subcutaneous Administration of a Lyophilized Powder Formulation in Healthy Volunteers
Abstract Background and Objective Hepcidin, an endogenous peptide hormone, binds to ferroportin and is the master regulator of iron trafficking. Rusfertide, a synthetic peptide, is a potent hepcidin mimetic. Clinical studies suggest rusfertide may be effective in the treatment of polycythemia vera....
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Adis, Springer Healthcare
2024-11-01
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| Series: | Drugs in R&D |
| Online Access: | https://doi.org/10.1007/s40268-024-00497-z |
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