Native and Engineered Extracellular Vesicles for the Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome
Extracellular vesicles (EVs) are lipid bilayer nanoparticles naturally released from cells, playing a crucial role in intercellular communication. They modulate gene expression and regulate physiological and pathological processes, including acute lung injury (ALI) and acute respiratory distress syn...
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2025-06-01
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| Series: | Small Science |
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| Online Access: | https://doi.org/10.1002/smsc.202400606 |
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| author | Zhengyan Gu Wenjun Xue Guanchao Mao Zhipeng Pei Jingjing Li Mingxue Sun Xinkang Zhang Shanshan Zhang Songling Li Jinfeng Cen Kai Xiao Ying Lu Qingqiang Xu |
| author_facet | Zhengyan Gu Wenjun Xue Guanchao Mao Zhipeng Pei Jingjing Li Mingxue Sun Xinkang Zhang Shanshan Zhang Songling Li Jinfeng Cen Kai Xiao Ying Lu Qingqiang Xu |
| author_sort | Zhengyan Gu |
| collection | DOAJ |
| description | Extracellular vesicles (EVs) are lipid bilayer nanoparticles naturally released from cells, playing a crucial role in intercellular communication. They modulate gene expression and regulate physiological and pathological processes, including acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Research has shown that EVs contain a variety of active components, are biocompatible and small in size, and do not trigger immune rejection, making the infusion of exogenous EVs a promising therapeutic tool. With further research, engineering strategies have been proposed to enhance the clinical potential of EVs. These strategies involve modifying either donor cells that secrete EVs or the EVs themselves and can be engineered to circumvent the limitations of native EVs. In this review, an overview of the biological properties of native EVs is provided and the current therapeutic potential of native and engineered EVs in treating ALI/ARDS, along with the latest research findings, is summarized. The challenges and opportunities for clinical translation of EVs as a novel therapeutic tool are also discussed, offering new insights into the treatment of ALI/ARDS using EV engineering technology. |
| format | Article |
| id | doaj-art-9fe94ee686d94c94b4d9ca7a291dcb45 |
| institution | DOAJ |
| issn | 2688-4046 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Small Science |
| spelling | doaj-art-9fe94ee686d94c94b4d9ca7a291dcb452025-08-20T02:39:40ZengWiley-VCHSmall Science2688-40462025-06-0156n/an/a10.1002/smsc.202400606Native and Engineered Extracellular Vesicles for the Treatment of Acute Lung Injury and Acute Respiratory Distress SyndromeZhengyan Gu0Wenjun Xue1Guanchao Mao2Zhipeng Pei3Jingjing Li4Mingxue Sun5Xinkang Zhang6Shanshan Zhang7Songling Li8Jinfeng Cen9Kai Xiao10Ying Lu11Qingqiang Xu12Department of Pharmaceutical Sciences School of Pharmacy Naval Medical University Shanghai 200433 P. R. ChinaSchool of Medicine Tongji University Shanghai 200070 P. R. ChinaLab of Toxicology and Pharmacology Faculty of Naval Medicine Naval Medical University Shanghai 200433 P. R. ChinaLab of Toxicology and Pharmacology Faculty of Naval Medicine Naval Medical University Shanghai 200433 P. R. ChinaLab of Toxicology and Pharmacology Faculty of Naval Medicine Naval Medical University Shanghai 200433 P. R. ChinaLab of Toxicology and Pharmacology Faculty of Naval Medicine Naval Medical University Shanghai 200433 P. R. ChinaLab of Toxicology and Pharmacology Faculty of Naval Medicine Naval Medical University Shanghai 200433 P. R. ChinaLab of Toxicology and Pharmacology Faculty of Naval Medicine Naval Medical University Shanghai 200433 P. R. ChinaLab of Toxicology and Pharmacology Faculty of Naval Medicine Naval Medical University Shanghai 200433 P. R. ChinaLab of Toxicology and Pharmacology Faculty of Naval Medicine Naval Medical University Shanghai 200433 P. R. ChinaLab of Toxicology and Pharmacology Faculty of Naval Medicine Naval Medical University Shanghai 200433 P. R. ChinaDepartment of Pharmaceutical Sciences School of Pharmacy Naval Medical University Shanghai 200433 P. R. ChinaLab of Toxicology and Pharmacology Faculty of Naval Medicine Naval Medical University Shanghai 200433 P. R. ChinaExtracellular vesicles (EVs) are lipid bilayer nanoparticles naturally released from cells, playing a crucial role in intercellular communication. They modulate gene expression and regulate physiological and pathological processes, including acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Research has shown that EVs contain a variety of active components, are biocompatible and small in size, and do not trigger immune rejection, making the infusion of exogenous EVs a promising therapeutic tool. With further research, engineering strategies have been proposed to enhance the clinical potential of EVs. These strategies involve modifying either donor cells that secrete EVs or the EVs themselves and can be engineered to circumvent the limitations of native EVs. In this review, an overview of the biological properties of native EVs is provided and the current therapeutic potential of native and engineered EVs in treating ALI/ARDS, along with the latest research findings, is summarized. The challenges and opportunities for clinical translation of EVs as a novel therapeutic tool are also discussed, offering new insights into the treatment of ALI/ARDS using EV engineering technology.https://doi.org/10.1002/smsc.202400606acute lung injuryacute respiratory distress syndromesengineered extracellular vesiclesextracellular vesicles |
| spellingShingle | Zhengyan Gu Wenjun Xue Guanchao Mao Zhipeng Pei Jingjing Li Mingxue Sun Xinkang Zhang Shanshan Zhang Songling Li Jinfeng Cen Kai Xiao Ying Lu Qingqiang Xu Native and Engineered Extracellular Vesicles for the Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome Small Science acute lung injury acute respiratory distress syndromes engineered extracellular vesicles extracellular vesicles |
| title | Native and Engineered Extracellular Vesicles for the Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome |
| title_full | Native and Engineered Extracellular Vesicles for the Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome |
| title_fullStr | Native and Engineered Extracellular Vesicles for the Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome |
| title_full_unstemmed | Native and Engineered Extracellular Vesicles for the Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome |
| title_short | Native and Engineered Extracellular Vesicles for the Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome |
| title_sort | native and engineered extracellular vesicles for the treatment of acute lung injury and acute respiratory distress syndrome |
| topic | acute lung injury acute respiratory distress syndromes engineered extracellular vesicles extracellular vesicles |
| url | https://doi.org/10.1002/smsc.202400606 |
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