Psoriasis: an emerging risk factor for ischemic stroke?
In 2020 nearly 12 million people worldwide suffered a stroke, and acute ischemic stroke (AIS) is the most frequent stroke subtype, accounting for approximately 65% of total stroke incidence. Therefore, primary prevention, including non-traditional risk factors, should be recognized as a major public...
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| Format: | Article |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1599978/full |
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| author | Piotr Olejnik Kaja Kasarełło Renata Podkowińska-Polak Aleksandra Golenia |
| author_facet | Piotr Olejnik Kaja Kasarełło Renata Podkowińska-Polak Aleksandra Golenia |
| author_sort | Piotr Olejnik |
| collection | DOAJ |
| description | In 2020 nearly 12 million people worldwide suffered a stroke, and acute ischemic stroke (AIS) is the most frequent stroke subtype, accounting for approximately 65% of total stroke incidence. Therefore, primary prevention, including non-traditional risk factors, should be recognized as a major public health priority. Research has shown that autoimmune diseases associated with chronic systemic inflammation, such as psoriasis, are commonly linked to AIS incidence. Psoriasis is a chronic autoimmune erythematous-squamous disease that primarily affects the skin, nails, and joints. Psoriasis is known to be a systemic inflammatory condition affecting multiple organs. Patients with psoriasis are at a higher risk of stroke than the general population, and a more severe disease course can increase this risk by up to 44%. One possible explanation for this phenomenon is that chronic systemic inflammation is associated with endothelial dysfunction and atherosclerotic plaque development. On the other hand, patients with psoriasis have an increased prevalence of traditional cardiovascular risk factors, including metabolic syndrome. This narrative review synthesizes the scientific literature to provide a comprehensive overview of the current understanding of the association between psoriasis and AIS. |
| format | Article |
| id | doaj-art-9fe92d00491f4fe38d2f0aaeb2bd1ba3 |
| institution | Kabale University |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj-art-9fe92d00491f4fe38d2f0aaeb2bd1ba32025-08-20T03:25:40ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-06-011610.3389/fneur.2025.15999781599978Psoriasis: an emerging risk factor for ischemic stroke?Piotr Olejnik0Kaja Kasarełło1Renata Podkowińska-Polak2Aleksandra Golenia3Department of Neurology, Medical University of Warsaw, Warsaw, PolandChair and Department of Experimental and Clinical Physiology, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, Warsaw, PolandDepartment of Pathology, Medical University of Warsaw, Warsaw, PolandDepartment of Neurology, Medical University of Warsaw, Warsaw, PolandIn 2020 nearly 12 million people worldwide suffered a stroke, and acute ischemic stroke (AIS) is the most frequent stroke subtype, accounting for approximately 65% of total stroke incidence. Therefore, primary prevention, including non-traditional risk factors, should be recognized as a major public health priority. Research has shown that autoimmune diseases associated with chronic systemic inflammation, such as psoriasis, are commonly linked to AIS incidence. Psoriasis is a chronic autoimmune erythematous-squamous disease that primarily affects the skin, nails, and joints. Psoriasis is known to be a systemic inflammatory condition affecting multiple organs. Patients with psoriasis are at a higher risk of stroke than the general population, and a more severe disease course can increase this risk by up to 44%. One possible explanation for this phenomenon is that chronic systemic inflammation is associated with endothelial dysfunction and atherosclerotic plaque development. On the other hand, patients with psoriasis have an increased prevalence of traditional cardiovascular risk factors, including metabolic syndrome. This narrative review synthesizes the scientific literature to provide a comprehensive overview of the current understanding of the association between psoriasis and AIS.https://www.frontiersin.org/articles/10.3389/fneur.2025.1599978/fullacute ischemic strokepsoriasissystemic inflammationautoimmune erythematous-squamous diseasetraditional cardiovascular risk factors |
| spellingShingle | Piotr Olejnik Kaja Kasarełło Renata Podkowińska-Polak Aleksandra Golenia Psoriasis: an emerging risk factor for ischemic stroke? Frontiers in Neurology acute ischemic stroke psoriasis systemic inflammation autoimmune erythematous-squamous disease traditional cardiovascular risk factors |
| title | Psoriasis: an emerging risk factor for ischemic stroke? |
| title_full | Psoriasis: an emerging risk factor for ischemic stroke? |
| title_fullStr | Psoriasis: an emerging risk factor for ischemic stroke? |
| title_full_unstemmed | Psoriasis: an emerging risk factor for ischemic stroke? |
| title_short | Psoriasis: an emerging risk factor for ischemic stroke? |
| title_sort | psoriasis an emerging risk factor for ischemic stroke |
| topic | acute ischemic stroke psoriasis systemic inflammation autoimmune erythematous-squamous disease traditional cardiovascular risk factors |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1599978/full |
| work_keys_str_mv | AT piotrolejnik psoriasisanemergingriskfactorforischemicstroke AT kajakasarełło psoriasisanemergingriskfactorforischemicstroke AT renatapodkowinskapolak psoriasisanemergingriskfactorforischemicstroke AT aleksandragolenia psoriasisanemergingriskfactorforischemicstroke |