Etiology and Mortality of Nonconvulsive Status Epilepticus
Objectives: Nonconvulsive status epilepticus (NCSE) is a disease with a high mortality rate and a very diverse etiology. The disease prognosis is related to the etiology. We aimed to investigate the etiology, mortality rates, and factors affecting mortality in patients diagnosed with NCSE in a terti...
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2025-02-01
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| author | Firdevs Ezgi Uçan Tokuç Emine Görgülü Fatma Genç Meltem Korucuk Abidin Erdal Yasemin Biçer Gömceli |
| author_facet | Firdevs Ezgi Uçan Tokuç Emine Görgülü Fatma Genç Meltem Korucuk Abidin Erdal Yasemin Biçer Gömceli |
| author_sort | Firdevs Ezgi Uçan Tokuç |
| collection | DOAJ |
| description | Objectives: Nonconvulsive status epilepticus (NCSE) is a disease with a high mortality rate and a very diverse etiology. The disease prognosis is related to the etiology. We aimed to investigate the etiology, mortality rates, and factors affecting mortality in patients diagnosed with NCSE in a tertiary epilepsy center in Turkey. Methods: All electroencephalograms (EEGs) were taken in the EEG laboratory of the Department of Neurology, Antalya Training and Research Hospital, between June 2021 and February 2024. Patients who met the Salzburg Consensus Criteria (SCC) for NCSE were included. Demographic data, etiologic factors, comorbidities, neuroradiological imaging, laboratory data, treatments administered for NCSE and responses to treatment, short- and long-term outcomes, and EEG findings at follow-up, if any, were noted from the medical records of all patients who met the criteria. Results: A total of 200 patients were included in the study. Mortality was observed in 76 (38.4%) patients with NCSE. There was a statistically significant correlation between NCSE etiology and mortality (<i>p</i> < 0.001). Mortality was most common in patients with cerebral tumors as the etiology, with a rate of 63.6%. The lowest mortality rate was observed in patients with autoimmune encephalitis and epilepsy (14.3% and 17.2%, respectively). After appropriate antiseizure medication (ASM) treatment, 117 (58.5%) patients with NCSE improved. When post-treatment improvement and etiologic factors were analyzed, the highest rate of improvement was observed in the autoimmune encephalitis and CVD groups. Conclusions: Our study showed that advanced age and the presence of stroke are associated with mortality and that patients with NCSE due to autoimmune encephalitis respond well to treatment. |
| format | Article |
| id | doaj-art-9fe7fb0fefbb4f2aa5a2fc6bc359b76d |
| institution | DOAJ |
| issn | 2035-8377 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Neurology International |
| spelling | doaj-art-9fe7fb0fefbb4f2aa5a2fc6bc359b76d2025-08-20T03:12:01ZengMDPI AGNeurology International2035-83772025-02-011722910.3390/neurolint17020029Etiology and Mortality of Nonconvulsive Status EpilepticusFirdevs Ezgi Uçan Tokuç0Emine Görgülü1Fatma Genç2Meltem Korucuk3Abidin Erdal4Yasemin Biçer Gömceli5Department of Neurology, University of Health Sciences, Antalya Training and Research Hospital, Antalya 07100, TurkeyDepartment of Neurology, University of Health Sciences, Antalya Training and Research Hospital, Antalya 07100, TurkeyDepartment of Neurology, University of Health Sciences, Antalya Training and Research Hospital, Antalya 07100, TurkeyDepartment of Neurology, University of Health Sciences, Antalya Training and Research Hospital, Antalya 07100, TurkeyDepartment of Neurology, Ankara Bilkent City Hospital, Health Ministry of Turkiye Republic, Ankara 06800, TurkeyDepartment of Neurology, Memorial Antalya Hospital, Antalya 07025, TurkeyObjectives: Nonconvulsive status epilepticus (NCSE) is a disease with a high mortality rate and a very diverse etiology. The disease prognosis is related to the etiology. We aimed to investigate the etiology, mortality rates, and factors affecting mortality in patients diagnosed with NCSE in a tertiary epilepsy center in Turkey. Methods: All electroencephalograms (EEGs) were taken in the EEG laboratory of the Department of Neurology, Antalya Training and Research Hospital, between June 2021 and February 2024. Patients who met the Salzburg Consensus Criteria (SCC) for NCSE were included. Demographic data, etiologic factors, comorbidities, neuroradiological imaging, laboratory data, treatments administered for NCSE and responses to treatment, short- and long-term outcomes, and EEG findings at follow-up, if any, were noted from the medical records of all patients who met the criteria. Results: A total of 200 patients were included in the study. Mortality was observed in 76 (38.4%) patients with NCSE. There was a statistically significant correlation between NCSE etiology and mortality (<i>p</i> < 0.001). Mortality was most common in patients with cerebral tumors as the etiology, with a rate of 63.6%. The lowest mortality rate was observed in patients with autoimmune encephalitis and epilepsy (14.3% and 17.2%, respectively). After appropriate antiseizure medication (ASM) treatment, 117 (58.5%) patients with NCSE improved. When post-treatment improvement and etiologic factors were analyzed, the highest rate of improvement was observed in the autoimmune encephalitis and CVD groups. Conclusions: Our study showed that advanced age and the presence of stroke are associated with mortality and that patients with NCSE due to autoimmune encephalitis respond well to treatment.https://www.mdpi.com/2035-8377/17/2/29epilepsynonconvulsive status epilepticusetiologymortalityantiseizure medication |
| spellingShingle | Firdevs Ezgi Uçan Tokuç Emine Görgülü Fatma Genç Meltem Korucuk Abidin Erdal Yasemin Biçer Gömceli Etiology and Mortality of Nonconvulsive Status Epilepticus Neurology International epilepsy nonconvulsive status epilepticus etiology mortality antiseizure medication |
| title | Etiology and Mortality of Nonconvulsive Status Epilepticus |
| title_full | Etiology and Mortality of Nonconvulsive Status Epilepticus |
| title_fullStr | Etiology and Mortality of Nonconvulsive Status Epilepticus |
| title_full_unstemmed | Etiology and Mortality of Nonconvulsive Status Epilepticus |
| title_short | Etiology and Mortality of Nonconvulsive Status Epilepticus |
| title_sort | etiology and mortality of nonconvulsive status epilepticus |
| topic | epilepsy nonconvulsive status epilepticus etiology mortality antiseizure medication |
| url | https://www.mdpi.com/2035-8377/17/2/29 |
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