Functions, mechanisms, and therapeutic implications of noncoding RNA in acute myeloid leukemia
Acute myeloid leukaemia (AML) is a malignant disease of myeloid hematopoietic stem/progenitor cells. Despite improved understanding of the pathogenesis of AML since the 1980s, the standard treatment for AML has remained virtually unchanged. Numerous studies have found poor survival rates and high re...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co. Ltd.
2025-07-01
|
| Series: | Fundamental Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667325823001309 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849245524758102016 |
|---|---|
| author | Xiaokang Wang Yong Tong Tianrong Xun Haixing Feng Yuhe Lei Yuanqing Li Kit Hang Wu Fang Qiu |
| author_facet | Xiaokang Wang Yong Tong Tianrong Xun Haixing Feng Yuhe Lei Yuanqing Li Kit Hang Wu Fang Qiu |
| author_sort | Xiaokang Wang |
| collection | DOAJ |
| description | Acute myeloid leukaemia (AML) is a malignant disease of myeloid hematopoietic stem/progenitor cells. Despite improved understanding of the pathogenesis of AML since the 1980s, the standard treatment for AML has remained virtually unchanged. Numerous studies have found poor survival rates and high relapse rates among older patients with AML. Several novel therapies for AML, including cytotoxic drugs, genetically- and epigenetically-targeted drugs, and immunotherapies, have been developed in recent years. Alternative treatments with improved efficacy are required for AML because many patients cannot tolerate the toxic effects of chemotherapy. Non-coding RNAs, including microRNAs (miRNAs), long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs), are attractive treatment targets for cancers and several other diseases. LncRNAs, miRNAs and circRNAs regulate DNA transcription and translation. Over the past decade, significant efforts have been made to develop RNA-based therapies, mainly antisense oligonucleotides and small interfering RNA, some of which have been approved for clinical use. Here we reviewed the mechanisms underlying the in vitro and in vivo effects of promising targets and potential drugs, focusing on the drugs most likely to be used for clinical treatment, to aid in the development of precision therapy for AML. |
| format | Article |
| id | doaj-art-9fe61b69205643ea8ce7bb4bfe08939c |
| institution | Kabale University |
| issn | 2667-3258 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | KeAi Communications Co. Ltd. |
| record_format | Article |
| series | Fundamental Research |
| spelling | doaj-art-9fe61b69205643ea8ce7bb4bfe08939c2025-08-20T03:58:45ZengKeAi Communications Co. Ltd.Fundamental Research2667-32582025-07-01541781179410.1016/j.fmre.2023.04.012Functions, mechanisms, and therapeutic implications of noncoding RNA in acute myeloid leukemiaXiaokang Wang0Yong Tong1Tianrong Xun2Haixing Feng3Yuhe Lei4Yuanqing Li5Kit Hang Wu6Fang Qiu7Department of Pharmacy, Shenzhen Longhua District Central Hospital, Shenzhen 518110, China; Department of Pharmacy, Shenzhen Hospital, Southern Medical University, Shenzhen 518000, China; Corresponding author.Department of Hematology, Shenzhen Hospital, Southern Medical University, Shenzhen 518000, ChinaDepartment of Pharmacy, Shenzhen Hospital, Southern Medical University, Shenzhen 518000, ChinaDepartment of Neurology, Shenzhen Institute of Translational Medicine, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen 518025, ChinaDepartment of Pharmacy, Shenzhen Hospital of Guangzhou University of Chinese Medicine, Shenzhen 518034, ChinaDepartment of Pharmacy, Shenzhen Longhua District Central Hospital, Shenzhen 518110, ChinaDepartment of Pharmacy, Nossa Senhora do Carmo - Lago Health Centre, Health Bureau, Macau 999078, ChinaDepartment of Burn and Plastic Surgery, Shenzhen Longhua District Central Hospital, Affiliated Central Hospital of Shenzhen Longhua District, Guangdong Medical University, Shenzhen 518110, ChinaAcute myeloid leukaemia (AML) is a malignant disease of myeloid hematopoietic stem/progenitor cells. Despite improved understanding of the pathogenesis of AML since the 1980s, the standard treatment for AML has remained virtually unchanged. Numerous studies have found poor survival rates and high relapse rates among older patients with AML. Several novel therapies for AML, including cytotoxic drugs, genetically- and epigenetically-targeted drugs, and immunotherapies, have been developed in recent years. Alternative treatments with improved efficacy are required for AML because many patients cannot tolerate the toxic effects of chemotherapy. Non-coding RNAs, including microRNAs (miRNAs), long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs), are attractive treatment targets for cancers and several other diseases. LncRNAs, miRNAs and circRNAs regulate DNA transcription and translation. Over the past decade, significant efforts have been made to develop RNA-based therapies, mainly antisense oligonucleotides and small interfering RNA, some of which have been approved for clinical use. Here we reviewed the mechanisms underlying the in vitro and in vivo effects of promising targets and potential drugs, focusing on the drugs most likely to be used for clinical treatment, to aid in the development of precision therapy for AML.http://www.sciencedirect.com/science/article/pii/S2667325823001309Noncoding RNAAcute myeloid leukaemiaMolecular targeted agentsChemoresistanceSmall molecule drugs |
| spellingShingle | Xiaokang Wang Yong Tong Tianrong Xun Haixing Feng Yuhe Lei Yuanqing Li Kit Hang Wu Fang Qiu Functions, mechanisms, and therapeutic implications of noncoding RNA in acute myeloid leukemia Fundamental Research Noncoding RNA Acute myeloid leukaemia Molecular targeted agents Chemoresistance Small molecule drugs |
| title | Functions, mechanisms, and therapeutic implications of noncoding RNA in acute myeloid leukemia |
| title_full | Functions, mechanisms, and therapeutic implications of noncoding RNA in acute myeloid leukemia |
| title_fullStr | Functions, mechanisms, and therapeutic implications of noncoding RNA in acute myeloid leukemia |
| title_full_unstemmed | Functions, mechanisms, and therapeutic implications of noncoding RNA in acute myeloid leukemia |
| title_short | Functions, mechanisms, and therapeutic implications of noncoding RNA in acute myeloid leukemia |
| title_sort | functions mechanisms and therapeutic implications of noncoding rna in acute myeloid leukemia |
| topic | Noncoding RNA Acute myeloid leukaemia Molecular targeted agents Chemoresistance Small molecule drugs |
| url | http://www.sciencedirect.com/science/article/pii/S2667325823001309 |
| work_keys_str_mv | AT xiaokangwang functionsmechanismsandtherapeuticimplicationsofnoncodingrnainacutemyeloidleukemia AT yongtong functionsmechanismsandtherapeuticimplicationsofnoncodingrnainacutemyeloidleukemia AT tianrongxun functionsmechanismsandtherapeuticimplicationsofnoncodingrnainacutemyeloidleukemia AT haixingfeng functionsmechanismsandtherapeuticimplicationsofnoncodingrnainacutemyeloidleukemia AT yuhelei functionsmechanismsandtherapeuticimplicationsofnoncodingrnainacutemyeloidleukemia AT yuanqingli functionsmechanismsandtherapeuticimplicationsofnoncodingrnainacutemyeloidleukemia AT kithangwu functionsmechanismsandtherapeuticimplicationsofnoncodingrnainacutemyeloidleukemia AT fangqiu functionsmechanismsandtherapeuticimplicationsofnoncodingrnainacutemyeloidleukemia |