Genomic profiling of interferon signaling pathway gene mutations in type 2 diabetic individuals with COVID-19
Comorbidities, especially diabetes, significantly contribute to the mortality and morbidity of COVID-19. Studies indicate higher rates of mortality and morbidity among diabetic COVID-19 patients compared to the general population. However, the precise mechanisms underlying this immune response remai...
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| Format: | Article |
| Language: | English |
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De Gruyter
2024-12-01
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| Series: | Türk Biyokimya Dergisi |
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| Online Access: | https://doi.org/10.1515/tjb-2024-0139 |
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| _version_ | 1850041936951377920 |
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| author | Tuluk Tuncay Kankılıç Teoman Civelek İlkay Akın Dilara Fatma Bankır Mehmet |
| author_facet | Tuluk Tuncay Kankılıç Teoman Civelek İlkay Akın Dilara Fatma Bankır Mehmet |
| author_sort | Tuluk Tuncay |
| collection | DOAJ |
| description | Comorbidities, especially diabetes, significantly contribute to the mortality and morbidity of COVID-19. Studies indicate higher rates of mortality and morbidity among diabetic COVID-19 patients compared to the general population. However, the precise mechanisms underlying this immune response remain incompletely understood. Our study aimed to explore potential disparities in COVID-19 prognosis among type 2 diabetic patients and investigate the genomic-level relationship between key proteins of the interferon signaling pathway: IFNAR1, IFNAR2, IRF3, and IRF7. |
| format | Article |
| id | doaj-art-9fe29dd7bbc249148c8029d972557267 |
| institution | DOAJ |
| issn | 1303-829X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Türk Biyokimya Dergisi |
| spelling | doaj-art-9fe29dd7bbc249148c8029d9725572672025-08-20T02:55:40ZengDe GruyterTürk Biyokimya Dergisi1303-829X2024-12-01501808810.1515/tjb-2024-0139Genomic profiling of interferon signaling pathway gene mutations in type 2 diabetic individuals with COVID-19Tuluk Tuncay0Kankılıç Teoman1Civelek İlkay2Akın Dilara Fatma3Bankır Mehmet4Department of Biotechnology, Faculty of Science, Niğde Ömer Halisdemir University, Niğde, TürkiyeDepartment of Biotechnology, Faculty of Science, Niğde Ömer Halisdemir University, Niğde, TürkiyeDepartment of Biotechnology, Faculty of Science, Niğde Ömer Halisdemir University, Niğde, TürkiyeDepartment of Medical Biology, Faculty of Medicine, Niğde Ömer Halisdemir University, Niğde, TürkiyeDepartment of Internal Medicine, Adana City Training and Research Hospital, Sağlık Bilimleri University, Adana, TürkiyeComorbidities, especially diabetes, significantly contribute to the mortality and morbidity of COVID-19. Studies indicate higher rates of mortality and morbidity among diabetic COVID-19 patients compared to the general population. However, the precise mechanisms underlying this immune response remain incompletely understood. Our study aimed to explore potential disparities in COVID-19 prognosis among type 2 diabetic patients and investigate the genomic-level relationship between key proteins of the interferon signaling pathway: IFNAR1, IFNAR2, IRF3, and IRF7.https://doi.org/10.1515/tjb-2024-0139covid-19type 2 diabetesmutationvariationinterferon signaling pathway |
| spellingShingle | Tuluk Tuncay Kankılıç Teoman Civelek İlkay Akın Dilara Fatma Bankır Mehmet Genomic profiling of interferon signaling pathway gene mutations in type 2 diabetic individuals with COVID-19 Türk Biyokimya Dergisi covid-19 type 2 diabetes mutation variation interferon signaling pathway |
| title | Genomic profiling of interferon signaling pathway gene mutations in type 2 diabetic individuals with COVID-19 |
| title_full | Genomic profiling of interferon signaling pathway gene mutations in type 2 diabetic individuals with COVID-19 |
| title_fullStr | Genomic profiling of interferon signaling pathway gene mutations in type 2 diabetic individuals with COVID-19 |
| title_full_unstemmed | Genomic profiling of interferon signaling pathway gene mutations in type 2 diabetic individuals with COVID-19 |
| title_short | Genomic profiling of interferon signaling pathway gene mutations in type 2 diabetic individuals with COVID-19 |
| title_sort | genomic profiling of interferon signaling pathway gene mutations in type 2 diabetic individuals with covid 19 |
| topic | covid-19 type 2 diabetes mutation variation interferon signaling pathway |
| url | https://doi.org/10.1515/tjb-2024-0139 |
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