Genomic profiling of interferon signaling pathway gene mutations in type 2 diabetic individuals with COVID-19

Genomic profiling of interferon signaling pathway gene mutations in type 2 diabetic individuals with COVID-19

Comorbidities, especially diabetes, significantly contribute to the mortality and morbidity of COVID-19. Studies indicate higher rates of mortality and morbidity among diabetic COVID-19 patients compared to the general population. However, the precise mechanisms underlying this immune response remai...

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Bibliographic Details
Main Authors: Tuluk Tuncay, Kankılıç Teoman, Civelek İlkay, Akın Dilara Fatma, Bankır Mehmet
Format: Article
Language:English
Published: De Gruyter 2024-12-01
Series:Türk Biyokimya Dergisi
Subjects:
covid-19
type 2 diabetes
mutation
variation
interferon signaling pathway
Online Access:https://doi.org/10.1515/tjb-2024-0139
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Summary:Comorbidities, especially diabetes, significantly contribute to the mortality and morbidity of COVID-19. Studies indicate higher rates of mortality and morbidity among diabetic COVID-19 patients compared to the general population. However, the precise mechanisms underlying this immune response remain incompletely understood. Our study aimed to explore potential disparities in COVID-19 prognosis among type 2 diabetic patients and investigate the genomic-level relationship between key proteins of the interferon signaling pathway: IFNAR1, IFNAR2, IRF3, and IRF7.
ISSN:1303-829X

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