NEW TARGET MICROVESICLES AND EXOSOMES IN CANCER
In recent years, a new mechanism for intercellular communication has been put forward which involves the intercellular transfer of extracellular vesicles. Most cancer cells release potentially functional biomolecules loaded in extracellular vesicles (EVs) such as DNA, proteins, lipids, and microRNAs...
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| Format: | Article |
| Language: | English |
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Istanbul University Press
2021-01-01
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| Series: | İstanbul Tıp Fakültesi Dergisi |
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| Online Access: | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/51C885204815452CAA956E199BA96AAB |
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| author | Sema Bolkent |
| author_facet | Sema Bolkent |
| author_sort | Sema Bolkent |
| collection | DOAJ |
| description | In recent years, a new mechanism for intercellular communication has been put forward which involves the intercellular transfer of extracellular vesicles. Most cancer cells release potentially functional biomolecules loaded in extracellular vesicles (EVs) such as DNA, proteins, lipids, and microRNAs. The experiments showed that EVs uptake by tumor cells can alter cellular behavior. Exosomes, a subtype of EVs, are small, lipid bilayer membrane vesicles for intercellular communication. Exosomes communicate with near-by and distant cancer cells that promote cancer development, metastasis, and drug resistance. In addition to intercellular communication, exosomes play a role in many biological processes such as signal transmission, genetic material transfer, and regulation of the immune response. EVs have emerged as an alternative mediator of communication within the tumor microenvironment and cancer metastasis. Because exosomes can change their content during various cancer treatments, they can play an important role in following the treatment. This review focuses on the function of EVs as signal transmitters between cells, called communicasomes (intercellular communication), and the importance of this function in cancer diagnosis and treatment. |
| format | Article |
| id | doaj-art-9fe0753e37ac439998c55fac8f1f77e1 |
| institution | OA Journals |
| issn | 1305-6441 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Istanbul University Press |
| record_format | Article |
| series | İstanbul Tıp Fakültesi Dergisi |
| spelling | doaj-art-9fe0753e37ac439998c55fac8f1f77e12025-08-20T02:15:33ZengIstanbul University Pressİstanbul Tıp Fakültesi Dergisi1305-64412021-01-0184113013410.26650/IUITFD.2020.0015123456NEW TARGET MICROVESICLES AND EXOSOMES IN CANCERSema Bolkent0https://orcid.org/0000-0001-8463-5561İstanbul Üniversitesi-Cerrahpaşa, Istanbul, TurkiyeIn recent years, a new mechanism for intercellular communication has been put forward which involves the intercellular transfer of extracellular vesicles. Most cancer cells release potentially functional biomolecules loaded in extracellular vesicles (EVs) such as DNA, proteins, lipids, and microRNAs. The experiments showed that EVs uptake by tumor cells can alter cellular behavior. Exosomes, a subtype of EVs, are small, lipid bilayer membrane vesicles for intercellular communication. Exosomes communicate with near-by and distant cancer cells that promote cancer development, metastasis, and drug resistance. In addition to intercellular communication, exosomes play a role in many biological processes such as signal transmission, genetic material transfer, and regulation of the immune response. EVs have emerged as an alternative mediator of communication within the tumor microenvironment and cancer metastasis. Because exosomes can change their content during various cancer treatments, they can play an important role in following the treatment. This review focuses on the function of EVs as signal transmitters between cells, called communicasomes (intercellular communication), and the importance of this function in cancer diagnosis and treatment.https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/51C885204815452CAA956E199BA96AABextracellular vesiclesexosomecancertherapy |
| spellingShingle | Sema Bolkent NEW TARGET MICROVESICLES AND EXOSOMES IN CANCER İstanbul Tıp Fakültesi Dergisi extracellular vesicles exosome cancer therapy |
| title | NEW TARGET MICROVESICLES AND EXOSOMES IN CANCER |
| title_full | NEW TARGET MICROVESICLES AND EXOSOMES IN CANCER |
| title_fullStr | NEW TARGET MICROVESICLES AND EXOSOMES IN CANCER |
| title_full_unstemmed | NEW TARGET MICROVESICLES AND EXOSOMES IN CANCER |
| title_short | NEW TARGET MICROVESICLES AND EXOSOMES IN CANCER |
| title_sort | new target microvesicles and exosomes in cancer |
| topic | extracellular vesicles exosome cancer therapy |
| url | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/51C885204815452CAA956E199BA96AAB |
| work_keys_str_mv | AT semabolkent newtargetmicrovesiclesandexosomesincancer |