Structure-Based Design of Head-Only Fusion Glycoprotein Immunogens for Respiratory Syncytial Virus.

Structure-Based Design of Head-Only Fusion Glycoprotein Immunogens for Respiratory Syncytial Virus.

Respiratory syncytial virus (RSV) is a significant cause of severe respiratory illness worldwide, particularly in infants, young children, and the elderly. Although no licensed vaccine is currently available, an engineered version of the metastable RSV fusion (F) surface glycoprotein-stabilized in t...

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Main Authors: Jeffrey C Boyington, M Gordon Joyce, Mallika Sastry, Guillaume B E Stewart-Jones, Man Chen, Wing-Pui Kong, Joan O Ngwuta, Paul V Thomas, Yaroslav Tsybovsky, Yongping Yang, Baoshan Zhang, Lei Chen, Aliaksandr Druz, Ivelin S Georgiev, Kiyoon Ko, Tongqing Zhou, John R Mascola, Barney S Graham, Peter D Kwong
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0159709&type=printable
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