ErbB- and MUC1-targeted CAR-T cell immunotherapy of oral squamous cell carcinoma

ErbB- and MUC1-targeted CAR-T cell immunotherapy of oral squamous cell carcinoma

Chimeric antigen receptor T (CAR-T) cell therapy has shown great success in treating B cell malignancies; however, there are many challenges that limit their therapeutic efficacy in solid tumours. Immunotherapy of head and neck squamous cell carcinoma (HNSCC), and, in particular, oral squamous cell...

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Bibliographic Details
Main Authors: Saffron E. Summers, Vehid Salih, Andrew D. Foey
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Dental Medicine
Subjects:
CAR-Ts
PD-L1
TAMs
ErbB
MUC1
OSCC
Online Access:https://www.frontiersin.org/articles/10.3389/fdmed.2023.1116402/full
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