Lipid accumulation inhibition strategies alleviate Fusobacterium nucleatum-infected colorectal cancer

Lipid accumulation inhibition strategies alleviate Fusobacterium nucleatum-infected colorectal cancer

Abstract Background Fusobacterium nucleatum (F. nucleatum) is prevalent in colorectal cancer (CRC), and it can promote proliferation and induce chemoresistance via multiple pathways. The development of treatment strategies for F. nucleatum-infected CRC is of great importance. Methods Shotgun metagen...

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Main Authors: Zhongkun Zhou, Yuqing Niu, Yunhao Ma, Dekui Zhang, Yiqing Wang, Rui Ji, Jianfang Zhao, Chi Ma, Hongmei Zhu, Yingqian Liu, Lixue Tu, Juan Lu, Baizhuo Zhang, Hua Zhang, Xin Ma, Peng Chen
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Microbiome
Subjects:
Colorectal cancer
Multiomics
F. nucleatum
Lipid accumulation
Bile acid
Drug rediscovery
Online Access:https://doi.org/10.1186/s40168-025-02133-7
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