Role of Vitamin D in Osteoarthritis: Molecular, Cellular, and Clinical Perspectives
Osteoarthritis is a debilitating and degenerative disease which affects millions of people worldwide. The causes and mechanisms of osteoarthritis remain to be fully understood. Vitamin D has been hypothesised to play essential roles in a number of diseases including osteoarthritis. Many cell types w...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/383918 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850169627145928704 |
|---|---|
| author | Thomas Mabey Sittisak Honsawek |
| author_facet | Thomas Mabey Sittisak Honsawek |
| author_sort | Thomas Mabey |
| collection | DOAJ |
| description | Osteoarthritis is a debilitating and degenerative disease which affects millions of people worldwide. The causes and mechanisms of osteoarthritis remain to be fully understood. Vitamin D has been hypothesised to play essential roles in a number of diseases including osteoarthritis. Many cell types within osteoarthritic joints appear to experience negative effects often at increased sensitivity to vitamin D. These findings contrast clinical research which has identified vitamin D deficiency to have a worryingly high prevalence among osteoarthritis patients. Randomised-controlled trial is considered to be the most rigorous way of determining the effects of vitamin D supplementation on the development of osteoarthritis. Studies into the effects of low vitamin D levels on pain and joint function have to date yielded controversial results. Due to the apparent conflicting effects of vitamin D in knee osteoarthritis, further research is required to fully elucidate its role in the development and progression of the disease as well as assess the efficacy and safety of vitamin D supplementation as a therapeutic strategy. |
| format | Article |
| id | doaj-art-9fd01c3334f342efa9c2db80ce0d94a6 |
| institution | OA Journals |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-9fd01c3334f342efa9c2db80ce0d94a62025-08-20T02:20:41ZengWileyInternational Journal of Endocrinology1687-83371687-83452015-01-01201510.1155/2015/383918383918Role of Vitamin D in Osteoarthritis: Molecular, Cellular, and Clinical PerspectivesThomas Mabey0Sittisak Honsawek1Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok 10330, ThailandDepartment of Biochemistry, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok 10330, ThailandOsteoarthritis is a debilitating and degenerative disease which affects millions of people worldwide. The causes and mechanisms of osteoarthritis remain to be fully understood. Vitamin D has been hypothesised to play essential roles in a number of diseases including osteoarthritis. Many cell types within osteoarthritic joints appear to experience negative effects often at increased sensitivity to vitamin D. These findings contrast clinical research which has identified vitamin D deficiency to have a worryingly high prevalence among osteoarthritis patients. Randomised-controlled trial is considered to be the most rigorous way of determining the effects of vitamin D supplementation on the development of osteoarthritis. Studies into the effects of low vitamin D levels on pain and joint function have to date yielded controversial results. Due to the apparent conflicting effects of vitamin D in knee osteoarthritis, further research is required to fully elucidate its role in the development and progression of the disease as well as assess the efficacy and safety of vitamin D supplementation as a therapeutic strategy.http://dx.doi.org/10.1155/2015/383918 |
| spellingShingle | Thomas Mabey Sittisak Honsawek Role of Vitamin D in Osteoarthritis: Molecular, Cellular, and Clinical Perspectives International Journal of Endocrinology |
| title | Role of Vitamin D in Osteoarthritis: Molecular, Cellular, and Clinical Perspectives |
| title_full | Role of Vitamin D in Osteoarthritis: Molecular, Cellular, and Clinical Perspectives |
| title_fullStr | Role of Vitamin D in Osteoarthritis: Molecular, Cellular, and Clinical Perspectives |
| title_full_unstemmed | Role of Vitamin D in Osteoarthritis: Molecular, Cellular, and Clinical Perspectives |
| title_short | Role of Vitamin D in Osteoarthritis: Molecular, Cellular, and Clinical Perspectives |
| title_sort | role of vitamin d in osteoarthritis molecular cellular and clinical perspectives |
| url | http://dx.doi.org/10.1155/2015/383918 |
| work_keys_str_mv | AT thomasmabey roleofvitamindinosteoarthritismolecularcellularandclinicalperspectives AT sittisakhonsawek roleofvitamindinosteoarthritismolecularcellularandclinicalperspectives |