Neurosteroid Activation of GABA-A Receptors: A Potential Treatment Target for Symptoms in Primary Biliary Cholangitis?

Neurosteroid Activation of GABA-A Receptors: A Potential Treatment Target for Symptoms in Primary Biliary Cholangitis?

Background and Aims. A third of patients with primary biliary cholangitis (PBC) experience poorly understood cognitive symptoms, with a significant impact on quality of life (QOL), and no effective medical treatment. Allopregnanolone, a neurosteroid, is a positive allosteric modulator of gamma-amino...

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Main Authors: Aaron Wetten, Laura Ogle, George Mells, Vinod S. Hegade, Laura Jopson, Margaret Corrigan, Jeremy Palmer, Maja Johansson, Torbjörn Bäckström, Magnus Doverskog, David E. J. Jones, Jessica K. Dyson
Format: Article
Language:English
Published: Wiley 2022-01-01
Series:Canadian Journal of Gastroenterology and Hepatology
Online Access:http://dx.doi.org/10.1155/2022/3618090
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