HLA-DR-DQ associations, combined with PLASMIC score, are reliable predictors of acquired thrombotic thrombocytopenic purpura (aTTP) and aid in differentiating aTTP from other thrombotic microangiopathies

HLA-DR-DQ associations, combined with PLASMIC score, are reliable predictors of acquired thrombotic thrombocytopenic purpura (aTTP) and aid in differentiating aTTP from other thrombotic microangiopathies

Background: Thrombotic microangiopathies (TMA) are a group of disorders with overlapping clinical features that require urgent intervention. Treatment is based on the recognition of the TMA type, which is often challenging. The aim of this study was to identify specific HLA associations with differe...

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Bibliographic Details
Main Authors: Soumya Pandey, Akul Shrivastava, Yanping Izak Harville, Michele Cottler-Fox, Terry O. Harville
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:Hematology, Transfusion and Cell Therapy
Subjects:
Thrombotic microangiopathies
HLA associations
PLASMIC score
PPV and NPV
Online Access:http://www.sciencedirect.com/science/article/pii/S2531137924000129
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