Role of Epstein-Barr Virus and Human Papilloma Virus in the Development of Oropharyngeal Cancer: A Literature Review
The aim of this review was to describe the association and related mechanisms between HPV, EBV, and the development of oral and oropharyngeal cancer. A search for scientific evidence was carried out in electronic databases (MEDLINE/PubMed, SciELO). It was found that, among the carcinogenic mechanism...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | International Journal of Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2022/3191569 |
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| author | Michela Migliaro Daniela Massuh María Fernanda Infante Ana María Brahm María Trinidad San Martín Duniel Ortuño |
| author_facet | Michela Migliaro Daniela Massuh María Fernanda Infante Ana María Brahm María Trinidad San Martín Duniel Ortuño |
| author_sort | Michela Migliaro |
| collection | DOAJ |
| description | The aim of this review was to describe the association and related mechanisms between HPV, EBV, and the development of oral and oropharyngeal cancer. A search for scientific evidence was carried out in electronic databases (MEDLINE/PubMed, SciELO). It was found that, among the carcinogenic mechanisms of HPV, E6 and E7 proteins are responsible for the malignization process, inhibiting tumor suppressors p53 and pRb. As to EBV, it was noted that its “hit and run” phenomenon manipulates the host epigenetic mechanism, triggering the tumor process without the virus being currently present; a “cellular reprogramming” is essentially generated, causing heritable changes in gene expression without DNA mutation. In conclusion, there is an association between oropharyngeal carcinogenesis and HPV and also between the former and EBV. Further studies are required to clarify the causal mechanisms and impact of both viruses on cancer development and to obtain biomarkers of greater specificity in the case of EBV. |
| format | Article |
| id | doaj-art-9fce078d87f749be8070383d90b5a403 |
| institution | Kabale University |
| issn | 1687-8736 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Dentistry |
| spelling | doaj-art-9fce078d87f749be8070383d90b5a4032025-02-03T05:57:27ZengWileyInternational Journal of Dentistry1687-87362022-01-01202210.1155/2022/3191569Role of Epstein-Barr Virus and Human Papilloma Virus in the Development of Oropharyngeal Cancer: A Literature ReviewMichela Migliaro0Daniela Massuh1María Fernanda Infante2Ana María Brahm3María Trinidad San Martín4Duniel Ortuño5Escuela de OdontologíaEscuela de OdontologíaEscuela de OdontologíaEscuela de OdontologíaEscuela de OdontologíaUniversidad de Los AndesThe aim of this review was to describe the association and related mechanisms between HPV, EBV, and the development of oral and oropharyngeal cancer. A search for scientific evidence was carried out in electronic databases (MEDLINE/PubMed, SciELO). It was found that, among the carcinogenic mechanisms of HPV, E6 and E7 proteins are responsible for the malignization process, inhibiting tumor suppressors p53 and pRb. As to EBV, it was noted that its “hit and run” phenomenon manipulates the host epigenetic mechanism, triggering the tumor process without the virus being currently present; a “cellular reprogramming” is essentially generated, causing heritable changes in gene expression without DNA mutation. In conclusion, there is an association between oropharyngeal carcinogenesis and HPV and also between the former and EBV. Further studies are required to clarify the causal mechanisms and impact of both viruses on cancer development and to obtain biomarkers of greater specificity in the case of EBV.http://dx.doi.org/10.1155/2022/3191569 |
| spellingShingle | Michela Migliaro Daniela Massuh María Fernanda Infante Ana María Brahm María Trinidad San Martín Duniel Ortuño Role of Epstein-Barr Virus and Human Papilloma Virus in the Development of Oropharyngeal Cancer: A Literature Review International Journal of Dentistry |
| title | Role of Epstein-Barr Virus and Human Papilloma Virus in the Development of Oropharyngeal Cancer: A Literature Review |
| title_full | Role of Epstein-Barr Virus and Human Papilloma Virus in the Development of Oropharyngeal Cancer: A Literature Review |
| title_fullStr | Role of Epstein-Barr Virus and Human Papilloma Virus in the Development of Oropharyngeal Cancer: A Literature Review |
| title_full_unstemmed | Role of Epstein-Barr Virus and Human Papilloma Virus in the Development of Oropharyngeal Cancer: A Literature Review |
| title_short | Role of Epstein-Barr Virus and Human Papilloma Virus in the Development of Oropharyngeal Cancer: A Literature Review |
| title_sort | role of epstein barr virus and human papilloma virus in the development of oropharyngeal cancer a literature review |
| url | http://dx.doi.org/10.1155/2022/3191569 |
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