Stroke Severity, Caregiver Feedback, and Cognition in the REGARDS‐CARES Study
Background Cognitive impairment after stroke is common and is present in up to 60% of survivors. Stroke severity, indicated by both volume and location, is the most consequential predictor of cognitive impairment, with severe strokes predicting higher chances of cognitive impairment. The current inv...
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| Language: | English |
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Wiley
2024-08-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
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| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.123.033375 |
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| author | Jason A. Blake D. Leann Long Amy J. Knight Burel R. Goodin Michael Crowe Suzanne E. Judd J. David Rhodes David L. Roth Olivio J. Clay |
| author_facet | Jason A. Blake D. Leann Long Amy J. Knight Burel R. Goodin Michael Crowe Suzanne E. Judd J. David Rhodes David L. Roth Olivio J. Clay |
| author_sort | Jason A. Blake |
| collection | DOAJ |
| description | Background Cognitive impairment after stroke is common and is present in up to 60% of survivors. Stroke severity, indicated by both volume and location, is the most consequential predictor of cognitive impairment, with severe strokes predicting higher chances of cognitive impairment. The current investigation examines the associations of 2 stroke severity ratings and a caregiver‐report of poststroke functioning with longitudinal cognitive outcomes. Methods and Results One hundred fifty‐seven caregivers and stroke survivor dyads participated in the CARES (Caring for Adults Recovering From the Effects of Stroke) project, an ancillary study of the REGARDS (Reasons for Geographic and Racial Differences in Stroke) national cohort study. The Glasgow Outcome Scale and modified Rankin Scale scores collected at hospitalization discharge were included as 2 primary predictors of cognitive impairment. The number of caregiver‐reported problems and impairments at 9 months following stroke were included as a third predictor. Cognition was measured using a biennial telephone battery and included the domains of learning, memory, and executive functioning. Multiple cognitive assessments were analyzed up to 5 years poststroke, controlling for prestroke cognition and demographic variables of the stroke survivor. Separate mixed models showed significant main effects of the Glasgow Outcome Scale (b=0.3380 [95% CI, 0.14–0.5]; P=0.0009), modified Rankin Scale (b=−0.2119 [95% CI, −0.32 to −0.10]; P=0.0002), and caregiver‐reported problems (b=−0.0671 [95% CI, −0.09 to −0.04]; P<0.0001) on longitudinal cognitive scores. In a combined model including all 3 predictors, only caregiver‐reported problems significantly predicted cognition (b=−0.0480 [95% CI, −0.08 to −0.03]; P<0.0001). Conclusions These findings emphasize the importance of caregiver feedback in predicting cognitive consequences of stroke. |
| format | Article |
| id | doaj-art-9fcad4b40aff4df095d9fd0aa8ff404b |
| institution | DOAJ |
| issn | 2047-9980 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj-art-9fcad4b40aff4df095d9fd0aa8ff404b2025-08-20T03:10:31ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802024-08-01131510.1161/JAHA.123.033375Stroke Severity, Caregiver Feedback, and Cognition in the REGARDS‐CARES StudyJason A. Blake0D. Leann Long1Amy J. Knight2Burel R. Goodin3Michael Crowe4Suzanne E. Judd5J. David Rhodes6David L. Roth7Olivio J. Clay8Department of Psychology University of Alabama at Birmingham Birmingham ALDepartment of Biostatistics University of Alabama at Birmingham Birmingham ALDepartment of Neurology University of Alabama at Birmingham Birmingham ALDepartment of Anesthesiology Washington University in St. Louis St. Louis MODepartment of Psychology University of Alabama at Birmingham Birmingham ALDepartment of Biostatistics University of Alabama at Birmingham Birmingham ALDepartment of Biostatistics University of Alabama at Birmingham Birmingham ALCenter on Aging and Health Johns Hopkins School of Medicine Baltimore MDDepartment of Psychology University of Alabama at Birmingham Birmingham ALBackground Cognitive impairment after stroke is common and is present in up to 60% of survivors. Stroke severity, indicated by both volume and location, is the most consequential predictor of cognitive impairment, with severe strokes predicting higher chances of cognitive impairment. The current investigation examines the associations of 2 stroke severity ratings and a caregiver‐report of poststroke functioning with longitudinal cognitive outcomes. Methods and Results One hundred fifty‐seven caregivers and stroke survivor dyads participated in the CARES (Caring for Adults Recovering From the Effects of Stroke) project, an ancillary study of the REGARDS (Reasons for Geographic and Racial Differences in Stroke) national cohort study. The Glasgow Outcome Scale and modified Rankin Scale scores collected at hospitalization discharge were included as 2 primary predictors of cognitive impairment. The number of caregiver‐reported problems and impairments at 9 months following stroke were included as a third predictor. Cognition was measured using a biennial telephone battery and included the domains of learning, memory, and executive functioning. Multiple cognitive assessments were analyzed up to 5 years poststroke, controlling for prestroke cognition and demographic variables of the stroke survivor. Separate mixed models showed significant main effects of the Glasgow Outcome Scale (b=0.3380 [95% CI, 0.14–0.5]; P=0.0009), modified Rankin Scale (b=−0.2119 [95% CI, −0.32 to −0.10]; P=0.0002), and caregiver‐reported problems (b=−0.0671 [95% CI, −0.09 to −0.04]; P<0.0001) on longitudinal cognitive scores. In a combined model including all 3 predictors, only caregiver‐reported problems significantly predicted cognition (b=−0.0480 [95% CI, −0.08 to −0.03]; P<0.0001). Conclusions These findings emphasize the importance of caregiver feedback in predicting cognitive consequences of stroke.https://www.ahajournals.org/doi/10.1161/JAHA.123.033375cognitionprognosisprospective studiesstroke carestroke severity |
| spellingShingle | Jason A. Blake D. Leann Long Amy J. Knight Burel R. Goodin Michael Crowe Suzanne E. Judd J. David Rhodes David L. Roth Olivio J. Clay Stroke Severity, Caregiver Feedback, and Cognition in the REGARDS‐CARES Study Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease cognition prognosis prospective studies stroke care stroke severity |
| title | Stroke Severity, Caregiver Feedback, and Cognition in the REGARDS‐CARES Study |
| title_full | Stroke Severity, Caregiver Feedback, and Cognition in the REGARDS‐CARES Study |
| title_fullStr | Stroke Severity, Caregiver Feedback, and Cognition in the REGARDS‐CARES Study |
| title_full_unstemmed | Stroke Severity, Caregiver Feedback, and Cognition in the REGARDS‐CARES Study |
| title_short | Stroke Severity, Caregiver Feedback, and Cognition in the REGARDS‐CARES Study |
| title_sort | stroke severity caregiver feedback and cognition in the regards cares study |
| topic | cognition prognosis prospective studies stroke care stroke severity |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.123.033375 |
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