Investigating the role of the metabolic score for visceral Fat in assessing the prevalence of chronic kidney disease from the NHANES 1999–2018
Abstract This study investigates the association between the Metabolic Score for Visceral Fat (METS-VF) and chronic kidney disease (CKD), assessing METS-VF as a potential predictor of CKD risk. Utilizing data from the 1999–2018 National Health and Nutrition Examination Survey (NHANES), this cross-se...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-01-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-025-86723-3 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832594783778897920 |
|---|---|
| author | Xingcheng Zhou Jiayi Xiang Shuxian Zhang Jun Yang Yi Tang Yalan Wang |
| author_facet | Xingcheng Zhou Jiayi Xiang Shuxian Zhang Jun Yang Yi Tang Yalan Wang |
| author_sort | Xingcheng Zhou |
| collection | DOAJ |
| description | Abstract This study investigates the association between the Metabolic Score for Visceral Fat (METS-VF) and chronic kidney disease (CKD), assessing METS-VF as a potential predictor of CKD risk. Utilizing data from the 1999–2018 National Health and Nutrition Examination Survey (NHANES), this cross-sectional study included 24,387 adult participants. Multivariable logistic regression, restricted cubic spline models, and threshold effect analyses were employed to explore the relationship. The results revealed a significant positive association, with multivariable logistic regression showing that each unit increase in METS-VF was associated with an 86% higher risk of CKD (OR: 1.86, 95% CI: 1.48–2.34). Critical METS-VF thresholds (6.10 and 7.55) were identified, at which CKD risk increased substantially. Subgroup analyses indicated that the association was particularly pronounced among older adults and males. These findings suggest that METS-VF is a reliable predictor for assessing CKD risk and that lifestyle interventions, including dietary modifications and exercise programs, may mitigate this risk. |
| format | Article |
| id | doaj-art-9fc96be31adc4eba975f8999e2638564 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-9fc96be31adc4eba975f8999e26385642025-01-19T12:21:29ZengNature PortfolioScientific Reports2045-23222025-01-0115111310.1038/s41598-025-86723-3Investigating the role of the metabolic score for visceral Fat in assessing the prevalence of chronic kidney disease from the NHANES 1999–2018Xingcheng Zhou0Jiayi Xiang1Shuxian Zhang2Jun Yang3Yi Tang4Yalan Wang5Department of Pathology, College of Basic Medicine, Chongqing Medical UniversityFifth Department of Medicine (Nephrology/Endocrinology/Rheumatology), University Medical Centre Mannheim, University of HeidelbergDepartment of Pathology, College of Basic Medicine, Chongqing Medical UniversityDepartment of Pathology, College of Basic Medicine, Chongqing Medical UniversityDepartment of Pathology, College of Basic Medicine, Chongqing Medical UniversityDepartment of Pathology, College of Basic Medicine, Chongqing Medical UniversityAbstract This study investigates the association between the Metabolic Score for Visceral Fat (METS-VF) and chronic kidney disease (CKD), assessing METS-VF as a potential predictor of CKD risk. Utilizing data from the 1999–2018 National Health and Nutrition Examination Survey (NHANES), this cross-sectional study included 24,387 adult participants. Multivariable logistic regression, restricted cubic spline models, and threshold effect analyses were employed to explore the relationship. The results revealed a significant positive association, with multivariable logistic regression showing that each unit increase in METS-VF was associated with an 86% higher risk of CKD (OR: 1.86, 95% CI: 1.48–2.34). Critical METS-VF thresholds (6.10 and 7.55) were identified, at which CKD risk increased substantially. Subgroup analyses indicated that the association was particularly pronounced among older adults and males. These findings suggest that METS-VF is a reliable predictor for assessing CKD risk and that lifestyle interventions, including dietary modifications and exercise programs, may mitigate this risk.https://doi.org/10.1038/s41598-025-86723-3 |
| spellingShingle | Xingcheng Zhou Jiayi Xiang Shuxian Zhang Jun Yang Yi Tang Yalan Wang Investigating the role of the metabolic score for visceral Fat in assessing the prevalence of chronic kidney disease from the NHANES 1999–2018 Scientific Reports |
| title | Investigating the role of the metabolic score for visceral Fat in assessing the prevalence of chronic kidney disease from the NHANES 1999–2018 |
| title_full | Investigating the role of the metabolic score for visceral Fat in assessing the prevalence of chronic kidney disease from the NHANES 1999–2018 |
| title_fullStr | Investigating the role of the metabolic score for visceral Fat in assessing the prevalence of chronic kidney disease from the NHANES 1999–2018 |
| title_full_unstemmed | Investigating the role of the metabolic score for visceral Fat in assessing the prevalence of chronic kidney disease from the NHANES 1999–2018 |
| title_short | Investigating the role of the metabolic score for visceral Fat in assessing the prevalence of chronic kidney disease from the NHANES 1999–2018 |
| title_sort | investigating the role of the metabolic score for visceral fat in assessing the prevalence of chronic kidney disease from the nhanes 1999 2018 |
| url | https://doi.org/10.1038/s41598-025-86723-3 |
| work_keys_str_mv | AT xingchengzhou investigatingtheroleofthemetabolicscoreforvisceralfatinassessingtheprevalenceofchronickidneydiseasefromthenhanes19992018 AT jiayixiang investigatingtheroleofthemetabolicscoreforvisceralfatinassessingtheprevalenceofchronickidneydiseasefromthenhanes19992018 AT shuxianzhang investigatingtheroleofthemetabolicscoreforvisceralfatinassessingtheprevalenceofchronickidneydiseasefromthenhanes19992018 AT junyang investigatingtheroleofthemetabolicscoreforvisceralfatinassessingtheprevalenceofchronickidneydiseasefromthenhanes19992018 AT yitang investigatingtheroleofthemetabolicscoreforvisceralfatinassessingtheprevalenceofchronickidneydiseasefromthenhanes19992018 AT yalanwang investigatingtheroleofthemetabolicscoreforvisceralfatinassessingtheprevalenceofchronickidneydiseasefromthenhanes19992018 |