Synthesis, Characterization and Anticancer Activity of Chitosan Schiff Base / PVP Gold Nano Composite in Treating Esophageal Cancer Cell Line
In the present paper, chitosan Schiff base has been synthesized from chitosan’s reaction with the salicyldehyde. The AuNPs was manufacture by extract of onion peels as a reducing agent. The Au NPs that have been prepared were characterized through the UV-vis spectroscopy, XRD analyses and SEM micro...
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University of Baghdad, College of Science for Women
2024-01-01
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| Series: | مجلة بغداد للعلوم |
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| Online Access: | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/7911 |
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| author | Maha A. Younus Baker F. Abdallaha |
| author_facet | Maha A. Younus Baker F. Abdallaha |
| author_sort | Maha A. Younus |
| collection | DOAJ |
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In the present paper, chitosan Schiff base has been synthesized from chitosan’s reaction with the salicyldehyde. The AuNPs was manufacture by extract of onion peels as a reducing agent. The Au NPs that have been prepared were characterized through the UV-vis spectroscopy, XRD analyses and SEM microscopy. The polymer blends of the chitosan Schiff base / PVP has been prepared through using the approach of solution casting. Chitosan Schiff base / PVP Au nano-composites was prepared. Nano composites and polymer blends have been characterized by FTIR which confirm the formation of Schiff base by revealing a new band of absorption at 1651cm-1 as a result of the (C=N) imine group. SEM, DSC and TGA confirms the thermal stability of the prepared polymer blends and nanocomposites, nano composites have shown good results in inhibiting esophageal cancer cell lines, IC50 of nanocomposite = 21.56 µg / mL.
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| format | Article |
| id | doaj-art-9fc0fd4a3f6e456982d69b4ad01c942b |
| institution | DOAJ |
| issn | 2078-8665 2411-7986 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | University of Baghdad, College of Science for Women |
| record_format | Article |
| series | مجلة بغداد للعلوم |
| spelling | doaj-art-9fc0fd4a3f6e456982d69b4ad01c942b2025-08-20T03:20:10ZengUniversity of Baghdad, College of Science for Womenمجلة بغداد للعلوم2078-86652411-79862024-01-0121110.21123/bsj.2023.7911Synthesis, Characterization and Anticancer Activity of Chitosan Schiff Base / PVP Gold Nano Composite in Treating Esophageal Cancer Cell LineMaha A. Younus0Baker F. Abdallaha1Department of Chemistry, College of Education for Pure Science (Ibn Al-Haitham), University of Baghdad, Baghdad, Iraq.Department of Chemistry, College of Science, University of Anbar, Ramadi, Iraq. In the present paper, chitosan Schiff base has been synthesized from chitosan’s reaction with the salicyldehyde. The AuNPs was manufacture by extract of onion peels as a reducing agent. The Au NPs that have been prepared were characterized through the UV-vis spectroscopy, XRD analyses and SEM microscopy. The polymer blends of the chitosan Schiff base / PVP has been prepared through using the approach of solution casting. Chitosan Schiff base / PVP Au nano-composites was prepared. Nano composites and polymer blends have been characterized by FTIR which confirm the formation of Schiff base by revealing a new band of absorption at 1651cm-1 as a result of the (C=N) imine group. SEM, DSC and TGA confirms the thermal stability of the prepared polymer blends and nanocomposites, nano composites have shown good results in inhibiting esophageal cancer cell lines, IC50 of nanocomposite = 21.56 µg / mL. https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/7911Anti-cancer cell line, Chitosan, Chitosan Schiff base, PVP, Nanocomposite |
| spellingShingle | Maha A. Younus Baker F. Abdallaha Synthesis, Characterization and Anticancer Activity of Chitosan Schiff Base / PVP Gold Nano Composite in Treating Esophageal Cancer Cell Line مجلة بغداد للعلوم Anti-cancer cell line, Chitosan, Chitosan Schiff base, PVP, Nanocomposite |
| title | Synthesis, Characterization and Anticancer Activity of Chitosan Schiff Base / PVP Gold Nano Composite in Treating Esophageal Cancer Cell Line |
| title_full | Synthesis, Characterization and Anticancer Activity of Chitosan Schiff Base / PVP Gold Nano Composite in Treating Esophageal Cancer Cell Line |
| title_fullStr | Synthesis, Characterization and Anticancer Activity of Chitosan Schiff Base / PVP Gold Nano Composite in Treating Esophageal Cancer Cell Line |
| title_full_unstemmed | Synthesis, Characterization and Anticancer Activity of Chitosan Schiff Base / PVP Gold Nano Composite in Treating Esophageal Cancer Cell Line |
| title_short | Synthesis, Characterization and Anticancer Activity of Chitosan Schiff Base / PVP Gold Nano Composite in Treating Esophageal Cancer Cell Line |
| title_sort | synthesis characterization and anticancer activity of chitosan schiff base pvp gold nano composite in treating esophageal cancer cell line |
| topic | Anti-cancer cell line, Chitosan, Chitosan Schiff base, PVP, Nanocomposite |
| url | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/7911 |
| work_keys_str_mv | AT mahaayounus synthesischaracterizationandanticanceractivityofchitosanschiffbasepvpgoldnanocompositeintreatingesophagealcancercellline AT bakerfabdallaha synthesischaracterizationandanticanceractivityofchitosanschiffbasepvpgoldnanocompositeintreatingesophagealcancercellline |