The impact of patient hydration and forced diuresis on [18F]PSMA-1007 urinary bladder uptake in PET/CT imaging
Abstract Background [18F]PSMA-1007 has minimal renal excretion, allowing for better assessment of the pelvic area in patients with prostate cancer (PCa). Nevertheless, there have been instances of notably high [18F]PSMA-1007 uptake in the urinary bladder. The purpose of this study was to assess the...
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2025-06-01
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| Online Access: | https://doi.org/10.1186/s13550-025-01271-1 |
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| author | Aleksandr Igorevich Khalimon Anastasia Igorevna Nikiforuk Malika Maratovna Khodzhibekova Gulnara Faridovna Khamadeeva Daria Yurevna Khodakova Tatyana Nikolaevna Lazutina Irina Valentinovna Pylova Aleksey Victorovich Leontyev Vitaly Sergeevich Bobrov Olga Valentinovna Mukhortova Irakly Pavlovich Aslanidi |
| author_facet | Aleksandr Igorevich Khalimon Anastasia Igorevna Nikiforuk Malika Maratovna Khodzhibekova Gulnara Faridovna Khamadeeva Daria Yurevna Khodakova Tatyana Nikolaevna Lazutina Irina Valentinovna Pylova Aleksey Victorovich Leontyev Vitaly Sergeevich Bobrov Olga Valentinovna Mukhortova Irakly Pavlovich Aslanidi |
| author_sort | Aleksandr Igorevich Khalimon |
| collection | DOAJ |
| description | Abstract Background [18F]PSMA-1007 has minimal renal excretion, allowing for better assessment of the pelvic area in patients with prostate cancer (PCa). Nevertheless, there have been instances of notably high [18F]PSMA-1007 uptake in the urinary bladder. The purpose of this study was to assess the impact of preliminary patient hydration and forced diuresis on [18F]PSMA-1007 urinary bladder uptake. Results А prospective single-center study included 185 patients with PCa, who underwent [18F]PSMA-1007 PET/CT. Patients were divided into 11 groups: a control group with no specific preparation (n = 35) and 10 experimental groups (n = 15 in each) with different preparation protocols, that included oral or IV hydration and/or furosemide administration. LBM SUVmean was used to quantify [18F]PSMA-1007 bladder uptake. The differences in bladder SUVmean among the different preparation groups, as well as compared to the control group, were evaluated. A p-value < 0.001 was considered statistically significant. Additionally, the variability of bladder SUVmean was assessed by evaluating the interquartile ranges (IQRs). The results indicate that the application of furosemide significantly reduced the median and variability of bladder SUVmean (p < 0.001), 30 min time interval of furosemide application prior to PET scan is preferable compared to 90 min interval (p < 0.001). Hydration alone, without furosemide, was insufficient for effectively reducing the median and variability of bladder SUVmean (p = 0.5). There was no significant difference between the groups with different routes and volumes of hydration (p = 0.03 and 0.45). Conclusion Forced diuresis is an effective tool for reducing the [18F]PSMA-1007 urinary bladder uptake and its variability when it is routinely increased. Clinical trial number Not applicable. |
| format | Article |
| id | doaj-art-9fbd319bf3bb4a4aaa3cf08726df3df4 |
| institution | Kabale University |
| issn | 2191-219X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | SpringerOpen |
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| series | EJNMMI Research |
| spelling | doaj-art-9fbd319bf3bb4a4aaa3cf08726df3df42025-08-20T03:47:17ZengSpringerOpenEJNMMI Research2191-219X2025-06-011511810.1186/s13550-025-01271-1The impact of patient hydration and forced diuresis on [18F]PSMA-1007 urinary bladder uptake in PET/CT imagingAleksandr Igorevich Khalimon0Anastasia Igorevna Nikiforuk1Malika Maratovna Khodzhibekova2Gulnara Faridovna Khamadeeva3Daria Yurevna Khodakova4Tatyana Nikolaevna Lazutina5Irina Valentinovna Pylova6Aleksey Victorovich Leontyev7Vitaly Sergeevich Bobrov8Olga Valentinovna Mukhortova9Irakly Pavlovich Aslanidi10Department of Nuclear Medicine, P. Hertsen Moscow Oncology Research Institute - The Branch of the FSBI “National Medical Research Radiological Centre” of the Ministry of Health of the Russian FederationDepartment of Nuclear Medicine, P. Hertsen Moscow Oncology Research Institute - The Branch of the FSBI “National Medical Research Radiological Centre” of the Ministry of Health of the Russian FederationDepartment of Nuclear Medicine, P. Hertsen Moscow Oncology Research Institute - The Branch of the FSBI “National Medical Research Radiological Centre” of the Ministry of Health of the Russian FederationDepartment of Nuclear Medicine, P. Hertsen Moscow Oncology Research Institute - The Branch of the FSBI “National Medical Research Radiological Centre” of the Ministry of Health of the Russian FederationDepartment of Nuclear Medicine, P. Hertsen Moscow Oncology Research Institute - The Branch of the FSBI “National Medical Research Radiological Centre” of the Ministry of Health of the Russian FederationDepartment of Nuclear Medicine, P. Hertsen Moscow Oncology Research Institute - The Branch of the FSBI “National Medical Research Radiological Centre” of the Ministry of Health of the Russian FederationDepartment of Nuclear Medicine, P. Hertsen Moscow Oncology Research Institute - The Branch of the FSBI “National Medical Research Radiological Centre” of the Ministry of Health of the Russian FederationDepartment of Nuclear Medicine, P. Hertsen Moscow Oncology Research Institute - The Branch of the FSBI “National Medical Research Radiological Centre” of the Ministry of Health of the Russian FederationDepartment of Nuclear Medicine, P. Hertsen Moscow Oncology Research Institute - The Branch of the FSBI “National Medical Research Radiological Centre” of the Ministry of Health of the Russian FederationDepartment of Nuclear Medicine, A. N. Bakulev National Medical Research Center for Cardiovascular Surgery of the Russian Ministry of HealthDepartment of Nuclear Medicine, A. N. Bakulev National Medical Research Center for Cardiovascular Surgery of the Russian Ministry of HealthAbstract Background [18F]PSMA-1007 has minimal renal excretion, allowing for better assessment of the pelvic area in patients with prostate cancer (PCa). Nevertheless, there have been instances of notably high [18F]PSMA-1007 uptake in the urinary bladder. The purpose of this study was to assess the impact of preliminary patient hydration and forced diuresis on [18F]PSMA-1007 urinary bladder uptake. Results А prospective single-center study included 185 patients with PCa, who underwent [18F]PSMA-1007 PET/CT. Patients were divided into 11 groups: a control group with no specific preparation (n = 35) and 10 experimental groups (n = 15 in each) with different preparation protocols, that included oral or IV hydration and/or furosemide administration. LBM SUVmean was used to quantify [18F]PSMA-1007 bladder uptake. The differences in bladder SUVmean among the different preparation groups, as well as compared to the control group, were evaluated. A p-value < 0.001 was considered statistically significant. Additionally, the variability of bladder SUVmean was assessed by evaluating the interquartile ranges (IQRs). The results indicate that the application of furosemide significantly reduced the median and variability of bladder SUVmean (p < 0.001), 30 min time interval of furosemide application prior to PET scan is preferable compared to 90 min interval (p < 0.001). Hydration alone, without furosemide, was insufficient for effectively reducing the median and variability of bladder SUVmean (p = 0.5). There was no significant difference between the groups with different routes and volumes of hydration (p = 0.03 and 0.45). Conclusion Forced diuresis is an effective tool for reducing the [18F]PSMA-1007 urinary bladder uptake and its variability when it is routinely increased. Clinical trial number Not applicable.https://doi.org/10.1186/s13550-025-01271-1Prostate cancerProstate-specific membrane antigenPET/CT[18F]PSMA-1007HydrationPharmacokinetics |
| spellingShingle | Aleksandr Igorevich Khalimon Anastasia Igorevna Nikiforuk Malika Maratovna Khodzhibekova Gulnara Faridovna Khamadeeva Daria Yurevna Khodakova Tatyana Nikolaevna Lazutina Irina Valentinovna Pylova Aleksey Victorovich Leontyev Vitaly Sergeevich Bobrov Olga Valentinovna Mukhortova Irakly Pavlovich Aslanidi The impact of patient hydration and forced diuresis on [18F]PSMA-1007 urinary bladder uptake in PET/CT imaging EJNMMI Research Prostate cancer Prostate-specific membrane antigen PET/CT [18F]PSMA-1007 Hydration Pharmacokinetics |
| title | The impact of patient hydration and forced diuresis on [18F]PSMA-1007 urinary bladder uptake in PET/CT imaging |
| title_full | The impact of patient hydration and forced diuresis on [18F]PSMA-1007 urinary bladder uptake in PET/CT imaging |
| title_fullStr | The impact of patient hydration and forced diuresis on [18F]PSMA-1007 urinary bladder uptake in PET/CT imaging |
| title_full_unstemmed | The impact of patient hydration and forced diuresis on [18F]PSMA-1007 urinary bladder uptake in PET/CT imaging |
| title_short | The impact of patient hydration and forced diuresis on [18F]PSMA-1007 urinary bladder uptake in PET/CT imaging |
| title_sort | impact of patient hydration and forced diuresis on 18f psma 1007 urinary bladder uptake in pet ct imaging |
| topic | Prostate cancer Prostate-specific membrane antigen PET/CT [18F]PSMA-1007 Hydration Pharmacokinetics |
| url | https://doi.org/10.1186/s13550-025-01271-1 |
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