Spleen Stiffness for Predicting Varices Needing Treatment: Comparison between Two Different Elastography Techniques (Point vs. 2D-SWE)
The study aimed to establish the benefits of using spleen stiffness values measured by two elastography techniques as noninvasive markers for predicting varices needing treatment and comparing their performances. A prospective study was performed, including 107 subjects with compensated liver cirrho...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Canadian Journal of Gastroenterology and Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2021/6622726 |
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| author | Renata Fofiu Felix Bende Raluca Lupuşoru Roxana Şirli Alina Popescu Ioan Sporea |
| author_facet | Renata Fofiu Felix Bende Raluca Lupuşoru Roxana Şirli Alina Popescu Ioan Sporea |
| author_sort | Renata Fofiu |
| collection | DOAJ |
| description | The study aimed to establish the benefits of using spleen stiffness values measured by two elastography techniques as noninvasive markers for predicting varices needing treatment and comparing their performances. A prospective study was performed, including 107 subjects with compensated liver cirrhosis, who underwent upper digestive endoscopy, as well as spleen stiffness measurements by means of two elastography techniques: pSWE (point shear wave elastography using Virtual Touch Quantification-Siemens Acuson S2000) and 2D-SWE (2D-shear wave elastography-LOGIQ E9, General Electric). Reliable spleen stiffness measurements were obtained in 96.2% (103/107) patients by means of 2D-SWE and in 94.4% (101/107) subjects with pSWE; therefore, 98 subjects were included in the final analysis, of which 40.8% (40/98) had varices needing treatment. The optimal spleen stiffness cut-off value by 2D-SWE for predicting varices needing treatment was 13.2 kPa (AUROC 0.84), while for pSWE, it was 2.91 m/s (AUROC 0.90). Based on AUROC comparison, no difference between the performance of the two techniques for predicting varices needing treatment was found (p=0.1606). In conclusion, spleen stiffness measured by either 2D-SWE or pSWE is a reliable surrogate marker, with good feasibility, applicability, and predictive accuracy for varices needing treatment, with no significant difference between techniques. |
| format | Article |
| id | doaj-art-9fbc91e2e1534100bddcd1719b1dc29e |
| institution | OA Journals |
| issn | 2291-2789 2291-2797 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology and Hepatology |
| spelling | doaj-art-9fbc91e2e1534100bddcd1719b1dc29e2025-08-20T02:20:09ZengWileyCanadian Journal of Gastroenterology and Hepatology2291-27892291-27972021-01-01202110.1155/2021/66227266622726Spleen Stiffness for Predicting Varices Needing Treatment: Comparison between Two Different Elastography Techniques (Point vs. 2D-SWE)Renata Fofiu0Felix Bende1Raluca Lupuşoru2Roxana Şirli3Alina Popescu4Ioan Sporea5Department of Gastroenterology and Hepatology, Victor Babeş University of Medicine and Pharmacy, Timişoara, RomaniaDepartment of Gastroenterology and Hepatology, Victor Babeş University of Medicine and Pharmacy, Timişoara, RomaniaDepartment of Gastroenterology and Hepatology, Victor Babeş University of Medicine and Pharmacy, Timişoara, RomaniaDepartment of Gastroenterology and Hepatology, Victor Babeş University of Medicine and Pharmacy, Timişoara, RomaniaDepartment of Gastroenterology and Hepatology, Victor Babeş University of Medicine and Pharmacy, Timişoara, RomaniaDepartment of Gastroenterology and Hepatology, Victor Babeş University of Medicine and Pharmacy, Timişoara, RomaniaThe study aimed to establish the benefits of using spleen stiffness values measured by two elastography techniques as noninvasive markers for predicting varices needing treatment and comparing their performances. A prospective study was performed, including 107 subjects with compensated liver cirrhosis, who underwent upper digestive endoscopy, as well as spleen stiffness measurements by means of two elastography techniques: pSWE (point shear wave elastography using Virtual Touch Quantification-Siemens Acuson S2000) and 2D-SWE (2D-shear wave elastography-LOGIQ E9, General Electric). Reliable spleen stiffness measurements were obtained in 96.2% (103/107) patients by means of 2D-SWE and in 94.4% (101/107) subjects with pSWE; therefore, 98 subjects were included in the final analysis, of which 40.8% (40/98) had varices needing treatment. The optimal spleen stiffness cut-off value by 2D-SWE for predicting varices needing treatment was 13.2 kPa (AUROC 0.84), while for pSWE, it was 2.91 m/s (AUROC 0.90). Based on AUROC comparison, no difference between the performance of the two techniques for predicting varices needing treatment was found (p=0.1606). In conclusion, spleen stiffness measured by either 2D-SWE or pSWE is a reliable surrogate marker, with good feasibility, applicability, and predictive accuracy for varices needing treatment, with no significant difference between techniques.http://dx.doi.org/10.1155/2021/6622726 |
| spellingShingle | Renata Fofiu Felix Bende Raluca Lupuşoru Roxana Şirli Alina Popescu Ioan Sporea Spleen Stiffness for Predicting Varices Needing Treatment: Comparison between Two Different Elastography Techniques (Point vs. 2D-SWE) Canadian Journal of Gastroenterology and Hepatology |
| title | Spleen Stiffness for Predicting Varices Needing Treatment: Comparison between Two Different Elastography Techniques (Point vs. 2D-SWE) |
| title_full | Spleen Stiffness for Predicting Varices Needing Treatment: Comparison between Two Different Elastography Techniques (Point vs. 2D-SWE) |
| title_fullStr | Spleen Stiffness for Predicting Varices Needing Treatment: Comparison between Two Different Elastography Techniques (Point vs. 2D-SWE) |
| title_full_unstemmed | Spleen Stiffness for Predicting Varices Needing Treatment: Comparison between Two Different Elastography Techniques (Point vs. 2D-SWE) |
| title_short | Spleen Stiffness for Predicting Varices Needing Treatment: Comparison between Two Different Elastography Techniques (Point vs. 2D-SWE) |
| title_sort | spleen stiffness for predicting varices needing treatment comparison between two different elastography techniques point vs 2d swe |
| url | http://dx.doi.org/10.1155/2021/6622726 |
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