Associations between the conicity index and kidney stone disease prevalence and mortality in American adults
Abstract Kidney Stone Disease (KSD) is a prevalent urological condition, while abdominal obesity is on the rise globally. The conicity index, measuring body fat distribution, is crucial but under-researched in its relation to KSD and all-cause mortality. This study, using data from 59,842 participan...
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Nature Portfolio
2025-01-01
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| author | Xianyu Dai Yu Chang Yuchuan Hou |
| author_facet | Xianyu Dai Yu Chang Yuchuan Hou |
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| description | Abstract Kidney Stone Disease (KSD) is a prevalent urological condition, while abdominal obesity is on the rise globally. The conicity index, measuring body fat distribution, is crucial but under-researched in its relation to KSD and all-cause mortality. This study, using data from 59,842 participants in the NHANES (2007–2018), calculated the conicity index from waist circumference, height, and weight. Logistic regression and Cox models revealed a significant positive correlation: each 0.1 unit increase in the conicity index was linked to a 23% rise in KSD odds (OR: 1.23, 95% CI: 1.14, 1.35) and higher predictive ability compared to traditional measures (AUC = 0.619). In KSD patients, this increase corresponded to a 44% higher risk of all-cause mortality (HR: 1.44, 95% CI: 1.14, 1.82), and in non-KSD patients, a 53% increase (HR: 1.53, 95% CI: 1.37, 1.70). Serum albumin and Red Cell Distribution Width (RDW) partially mediated these relationships. Addressing central obesity could significantly lower the risks of KSD and mortality. |
| format | Article |
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| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-9fb9544bd7944a0aabc2556b9803d4cb2025-08-20T02:40:33ZengNature PortfolioScientific Reports2045-23222025-01-0115111310.1038/s41598-025-85292-9Associations between the conicity index and kidney stone disease prevalence and mortality in American adultsXianyu Dai0Yu Chang1Yuchuan Hou2Department of Urology, The First Hospital of Jilin UniversityDepartment of Gastroenterology, The First Hospital of Jilin UniversityDepartment of Urology, The First Hospital of Jilin UniversityAbstract Kidney Stone Disease (KSD) is a prevalent urological condition, while abdominal obesity is on the rise globally. The conicity index, measuring body fat distribution, is crucial but under-researched in its relation to KSD and all-cause mortality. This study, using data from 59,842 participants in the NHANES (2007–2018), calculated the conicity index from waist circumference, height, and weight. Logistic regression and Cox models revealed a significant positive correlation: each 0.1 unit increase in the conicity index was linked to a 23% rise in KSD odds (OR: 1.23, 95% CI: 1.14, 1.35) and higher predictive ability compared to traditional measures (AUC = 0.619). In KSD patients, this increase corresponded to a 44% higher risk of all-cause mortality (HR: 1.44, 95% CI: 1.14, 1.82), and in non-KSD patients, a 53% increase (HR: 1.53, 95% CI: 1.37, 1.70). Serum albumin and Red Cell Distribution Width (RDW) partially mediated these relationships. Addressing central obesity could significantly lower the risks of KSD and mortality.https://doi.org/10.1038/s41598-025-85292-9Kidney stone diseaseConicity indexAll-cause mortalitySerum albuminRed cell distribution widthNHANES |
| spellingShingle | Xianyu Dai Yu Chang Yuchuan Hou Associations between the conicity index and kidney stone disease prevalence and mortality in American adults Scientific Reports Kidney stone disease Conicity index All-cause mortality Serum albumin Red cell distribution width NHANES |
| title | Associations between the conicity index and kidney stone disease prevalence and mortality in American adults |
| title_full | Associations between the conicity index and kidney stone disease prevalence and mortality in American adults |
| title_fullStr | Associations between the conicity index and kidney stone disease prevalence and mortality in American adults |
| title_full_unstemmed | Associations between the conicity index and kidney stone disease prevalence and mortality in American adults |
| title_short | Associations between the conicity index and kidney stone disease prevalence and mortality in American adults |
| title_sort | associations between the conicity index and kidney stone disease prevalence and mortality in american adults |
| topic | Kidney stone disease Conicity index All-cause mortality Serum albumin Red cell distribution width NHANES |
| url | https://doi.org/10.1038/s41598-025-85292-9 |
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