In Vitro Permeation of Micronized and Nanonized Alaptide from Semisolid Formulations
This study is focused on in vitro permeation of the original Czech compound, a skin/mucosa tissue regeneration promoter, known under the international nonproprietary name “alaptide,” in micronized and nanonized forms. Alaptide showed a great potential for local applications for treatment and/or rege...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/787283 |
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| author | Radka Opatrilova Aneta Cernikova Lenka Coufalova Jiri Dohnal Josef Jampilek |
| author_facet | Radka Opatrilova Aneta Cernikova Lenka Coufalova Jiri Dohnal Josef Jampilek |
| author_sort | Radka Opatrilova |
| collection | DOAJ |
| description | This study is focused on in vitro permeation of the original Czech compound, a skin/mucosa tissue regeneration promoter, known under the international nonproprietary name “alaptide,” in micronized and nanonized forms. Alaptide showed a great potential for local applications for treatment and/or regeneration of the injured skin. The above mentioned technological modifications influence the permeation of alaptide through artificial or biological membranes, such as PAMPA or skin. The permeation of micronized and nanonized form of alaptide formulated to various semisolid pharmaceutical compositions through full-thickness pig ear skin using a Franz cell has been investigated in detail. In general, it can be concluded that the nanonized alaptide permeated through the skin less than the micronized form; different observations were made for permeation through the PAMPA system, where the micronized form showed lower permeation than the nanonized alaptide. |
| format | Article |
| id | doaj-art-9fb6fe99b40c4271bec3d67e168f07fd |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-9fb6fe99b40c4271bec3d67e168f07fd2025-08-20T03:38:27ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/787283787283In Vitro Permeation of Micronized and Nanonized Alaptide from Semisolid FormulationsRadka Opatrilova0Aneta Cernikova1Lenka Coufalova2Jiri Dohnal3Josef Jampilek4Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackeho 1/3, 61242 Brno, Czech RepublicDepartment of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackeho 1/3, 61242 Brno, Czech RepublicDepartment of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackeho 1/3, 61242 Brno, Czech RepublicDepartment of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackeho 1/3, 61242 Brno, Czech RepublicDepartment of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackeho 1/3, 61242 Brno, Czech RepublicThis study is focused on in vitro permeation of the original Czech compound, a skin/mucosa tissue regeneration promoter, known under the international nonproprietary name “alaptide,” in micronized and nanonized forms. Alaptide showed a great potential for local applications for treatment and/or regeneration of the injured skin. The above mentioned technological modifications influence the permeation of alaptide through artificial or biological membranes, such as PAMPA or skin. The permeation of micronized and nanonized form of alaptide formulated to various semisolid pharmaceutical compositions through full-thickness pig ear skin using a Franz cell has been investigated in detail. In general, it can be concluded that the nanonized alaptide permeated through the skin less than the micronized form; different observations were made for permeation through the PAMPA system, where the micronized form showed lower permeation than the nanonized alaptide.http://dx.doi.org/10.1155/2013/787283 |
| spellingShingle | Radka Opatrilova Aneta Cernikova Lenka Coufalova Jiri Dohnal Josef Jampilek In Vitro Permeation of Micronized and Nanonized Alaptide from Semisolid Formulations The Scientific World Journal |
| title | In Vitro Permeation of Micronized and Nanonized Alaptide from Semisolid Formulations |
| title_full | In Vitro Permeation of Micronized and Nanonized Alaptide from Semisolid Formulations |
| title_fullStr | In Vitro Permeation of Micronized and Nanonized Alaptide from Semisolid Formulations |
| title_full_unstemmed | In Vitro Permeation of Micronized and Nanonized Alaptide from Semisolid Formulations |
| title_short | In Vitro Permeation of Micronized and Nanonized Alaptide from Semisolid Formulations |
| title_sort | in vitro permeation of micronized and nanonized alaptide from semisolid formulations |
| url | http://dx.doi.org/10.1155/2013/787283 |
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