IGF-I and relation to growth in infancy and early childhood in very-low-birth-weight infants and term born infants.
<h4>Background</h4>In very-low-birth-weight infants IGF-I plays an important role in postnatal growth restriction and is probably also involved in growth restriction in childhood. We compared IGF-I and its relation to growth in early childhood in very-low-birth-weight infants and term ap...
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0171650&type=printable |
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| author | Miranda de Jong Anneke Cranendonk Jos W R Twisk Mirjam M van Weissenbruch |
| author_facet | Miranda de Jong Anneke Cranendonk Jos W R Twisk Mirjam M van Weissenbruch |
| author_sort | Miranda de Jong |
| collection | DOAJ |
| description | <h4>Background</h4>In very-low-birth-weight infants IGF-I plays an important role in postnatal growth restriction and is probably also involved in growth restriction in childhood. We compared IGF-I and its relation to growth in early childhood in very-low-birth-weight infants and term appropriate for gestational age born infants.<h4>Methods</h4>We included 41 very-low-birth-weight and 64 term infants. Anthropometry was performed at all visits to the outpatient clinic. IGF-I and insulin were measured in blood samples taken at 6 months and 2 years corrected age (very-low-birth-weight children) and at 3 months, 1 and 2 years (term children).<h4>Results</h4>Over the first 2 years of life growth parameters are lower in very-low-birth-weight children compared to term children, but the difference in length decreases significantly. During the first 2 years of life IGF-I is higher in very-low-birth-weight children compared to term children. In both groups there is a significant relationship between IGF-I and (change in) length and weight over the first 2 years of life and between insulin and change in total body fat.<h4>Conclusions</h4>Considering the relation of IGF-I to growth and the decrease in difference in length, higher IGF-I levels in very-low-birth-weight infants in early childhood probably have an important role in catch-up growth in length. |
| format | Article |
| id | doaj-art-9fb67b57740e42d18d1a591a0f5754c5 |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
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| spelling | doaj-art-9fb67b57740e42d18d1a591a0f5754c52025-08-20T03:12:50ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01122e017165010.1371/journal.pone.0171650IGF-I and relation to growth in infancy and early childhood in very-low-birth-weight infants and term born infants.Miranda de JongAnneke CranendonkJos W R TwiskMirjam M van Weissenbruch<h4>Background</h4>In very-low-birth-weight infants IGF-I plays an important role in postnatal growth restriction and is probably also involved in growth restriction in childhood. We compared IGF-I and its relation to growth in early childhood in very-low-birth-weight infants and term appropriate for gestational age born infants.<h4>Methods</h4>We included 41 very-low-birth-weight and 64 term infants. Anthropometry was performed at all visits to the outpatient clinic. IGF-I and insulin were measured in blood samples taken at 6 months and 2 years corrected age (very-low-birth-weight children) and at 3 months, 1 and 2 years (term children).<h4>Results</h4>Over the first 2 years of life growth parameters are lower in very-low-birth-weight children compared to term children, but the difference in length decreases significantly. During the first 2 years of life IGF-I is higher in very-low-birth-weight children compared to term children. In both groups there is a significant relationship between IGF-I and (change in) length and weight over the first 2 years of life and between insulin and change in total body fat.<h4>Conclusions</h4>Considering the relation of IGF-I to growth and the decrease in difference in length, higher IGF-I levels in very-low-birth-weight infants in early childhood probably have an important role in catch-up growth in length.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0171650&type=printable |
| spellingShingle | Miranda de Jong Anneke Cranendonk Jos W R Twisk Mirjam M van Weissenbruch IGF-I and relation to growth in infancy and early childhood in very-low-birth-weight infants and term born infants. PLoS ONE |
| title | IGF-I and relation to growth in infancy and early childhood in very-low-birth-weight infants and term born infants. |
| title_full | IGF-I and relation to growth in infancy and early childhood in very-low-birth-weight infants and term born infants. |
| title_fullStr | IGF-I and relation to growth in infancy and early childhood in very-low-birth-weight infants and term born infants. |
| title_full_unstemmed | IGF-I and relation to growth in infancy and early childhood in very-low-birth-weight infants and term born infants. |
| title_short | IGF-I and relation to growth in infancy and early childhood in very-low-birth-weight infants and term born infants. |
| title_sort | igf i and relation to growth in infancy and early childhood in very low birth weight infants and term born infants |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0171650&type=printable |
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