Revaccination following CAR-T therapy: a needs assessment
Background: CD19-targeted chimeric antigen receptor T-cell (CAR-T) therapy has transformed treatment for relapsed/refractory large B-cell lymphoma, offering promising remission rates. However, it carries significant infectious risks, necessitating revaccination for infection prevention.Methods: This...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Hematology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/16078454.2025.2519865 |
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| author | Robert Clayden Barbara Gunka Brittany Salter Audrey Y. H. Dong Kylie Lepic Gwynivere Davies Amaris Balitsky |
| author_facet | Robert Clayden Barbara Gunka Brittany Salter Audrey Y. H. Dong Kylie Lepic Gwynivere Davies Amaris Balitsky |
| author_sort | Robert Clayden |
| collection | DOAJ |
| description | Background: CD19-targeted chimeric antigen receptor T-cell (CAR-T) therapy has transformed treatment for relapsed/refractory large B-cell lymphoma, offering promising remission rates. However, it carries significant infectious risks, necessitating revaccination for infection prevention.Methods: This single-center quality improvement study aimed to (1) assess revaccination uptake and barriers in CAR-T recipients through interviews and focus groups, and (2) use qualitative insights to develop an educational handout to improve revaccination adherence. The study was conducted at Juravinski Hospital and Cancer Centre, Hamilton, Ontario, and enrolled 22 patients who received CAR-T between January 2020 and June 2023. Participants completed a survey evaluating their revaccination experience, which informed the development of a patient-facing educational handout. A focus group of survey participants then reviewed the handout and offered feedback on its clarity and usefulness.Results: Only 50% of participants proceeded with revaccination. Key barriers included limited awareness among primary care providers (PCPs), poor communication between hematologists and PCPs, and logistical difficulties. The focus group highlighted gaps in understanding post-CAR-T immunization needs and emphasized the importance of patient and physician education. Participants supported the creation of a concise handout outlining the revaccination schedule and clarified the PCP's role in coordination.Conclusion: This study underscores the need for improved communication across care providers and accessible patient education to support post-CAR-T revaccination. Future efforts should focus on implementing and evaluating targeted educational tools to enhance vaccine uptake in this high-risk population.. |
| format | Article |
| id | doaj-art-9fb60c0899c74fda8dc57259d54fdc90 |
| institution | Kabale University |
| issn | 1607-8454 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Hematology |
| spelling | doaj-art-9fb60c0899c74fda8dc57259d54fdc902025-08-20T03:29:34ZengTaylor & Francis GroupHematology1607-84542025-12-0130110.1080/16078454.2025.2519865Revaccination following CAR-T therapy: a needs assessmentRobert Clayden0Barbara Gunka1Brittany Salter2Audrey Y. H. Dong3Kylie Lepic4Gwynivere Davies5Amaris Balitsky6Department of Oncology, St Catharines General Hospital, St Catharines, CanadaDepartment of Medicine, McMaster University, Hamilton, CanadaDepartment of Medicine, McMaster University, Hamilton, CanadaDepartment of Medicine, McMaster University, Hamilton, CanadaDepartment of Oncology, McMaster University, Hamilton, CanadaDepartment of Oncology, McMaster University, Hamilton, CanadaDepartment of Oncology, McMaster University, Hamilton, CanadaBackground: CD19-targeted chimeric antigen receptor T-cell (CAR-T) therapy has transformed treatment for relapsed/refractory large B-cell lymphoma, offering promising remission rates. However, it carries significant infectious risks, necessitating revaccination for infection prevention.Methods: This single-center quality improvement study aimed to (1) assess revaccination uptake and barriers in CAR-T recipients through interviews and focus groups, and (2) use qualitative insights to develop an educational handout to improve revaccination adherence. The study was conducted at Juravinski Hospital and Cancer Centre, Hamilton, Ontario, and enrolled 22 patients who received CAR-T between January 2020 and June 2023. Participants completed a survey evaluating their revaccination experience, which informed the development of a patient-facing educational handout. A focus group of survey participants then reviewed the handout and offered feedback on its clarity and usefulness.Results: Only 50% of participants proceeded with revaccination. Key barriers included limited awareness among primary care providers (PCPs), poor communication between hematologists and PCPs, and logistical difficulties. The focus group highlighted gaps in understanding post-CAR-T immunization needs and emphasized the importance of patient and physician education. Participants supported the creation of a concise handout outlining the revaccination schedule and clarified the PCP's role in coordination.Conclusion: This study underscores the need for improved communication across care providers and accessible patient education to support post-CAR-T revaccination. Future efforts should focus on implementing and evaluating targeted educational tools to enhance vaccine uptake in this high-risk population..https://www.tandfonline.com/doi/10.1080/16078454.2025.2519865CAR-TvaccinationLBCLlymphoma |
| spellingShingle | Robert Clayden Barbara Gunka Brittany Salter Audrey Y. H. Dong Kylie Lepic Gwynivere Davies Amaris Balitsky Revaccination following CAR-T therapy: a needs assessment Hematology CAR-T vaccination LBCL lymphoma |
| title | Revaccination following CAR-T therapy: a needs assessment |
| title_full | Revaccination following CAR-T therapy: a needs assessment |
| title_fullStr | Revaccination following CAR-T therapy: a needs assessment |
| title_full_unstemmed | Revaccination following CAR-T therapy: a needs assessment |
| title_short | Revaccination following CAR-T therapy: a needs assessment |
| title_sort | revaccination following car t therapy a needs assessment |
| topic | CAR-T vaccination LBCL lymphoma |
| url | https://www.tandfonline.com/doi/10.1080/16078454.2025.2519865 |
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