Role of Probiotics in the Management of Patients with Ulcerative Colitis and Pouchitis
Acute severe ulcerative colitis (ASUC) often requires surgical intervention, such as proctocolectomy with ileal pouch–anal anastomosis (IPAA). While IPAA improves patient outcomes, it can be associated with pouchitis, a common and debilitating complication characterized by inflammation of the pouch....
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MDPI AG
2024-12-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/13/1/19 |
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| author | Francesca Bernardi Fabrizio Fanizzi Tommaso Lorenzo Parigi Alessandra Zilli Mariangela Allocca Federica Furfaro Laurent Peyrin-Biroulet Silvio Danese Ferdinando D’Amico |
| author_facet | Francesca Bernardi Fabrizio Fanizzi Tommaso Lorenzo Parigi Alessandra Zilli Mariangela Allocca Federica Furfaro Laurent Peyrin-Biroulet Silvio Danese Ferdinando D’Amico |
| author_sort | Francesca Bernardi |
| collection | DOAJ |
| description | Acute severe ulcerative colitis (ASUC) often requires surgical intervention, such as proctocolectomy with ileal pouch–anal anastomosis (IPAA). While IPAA improves patient outcomes, it can be associated with pouchitis, a common and debilitating complication characterized by inflammation of the pouch. The development of pouchitis is closely linked to dysbiosis—an imbalance in the gut microbiota. Understanding the role of the microbiota in pouch health has spurred interest in probiotics as a therapeutic strategy. Probiotics represent a promising avenue in the management of pouchitis, offering a natural and targeted approach to improving outcomes for UC patients. This review explores the role of probiotics in the management of UC patients, with a specific focus on preventing and treating pouchitis. We compare the microbiota of healthy pouches to those with pouchitis, highlighting key microbial shifts linked to disease onset and discussing the growing evidence for probiotics as a prevention and therapeutic approach. Future directions should prioritize advancing research to optimize probiotic therapies and establish personalized approaches based on individual microbiome profiles, highlighting their significant potential as a promising treatment strategy for pouchitis. |
| format | Article |
| id | doaj-art-9fb464516e3b4552b237a8919a949cd3 |
| institution | Kabale University |
| issn | 2076-2607 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj-art-9fb464516e3b4552b237a8919a949cd32025-01-24T13:42:18ZengMDPI AGMicroorganisms2076-26072024-12-011311910.3390/microorganisms13010019Role of Probiotics in the Management of Patients with Ulcerative Colitis and PouchitisFrancesca Bernardi0Fabrizio Fanizzi1Tommaso Lorenzo Parigi2Alessandra Zilli3Mariangela Allocca4Federica Furfaro5Laurent Peyrin-Biroulet6Silvio Danese7Ferdinando D’Amico8Gastroenterology and Endoscopy IRCCS, Ospedale San Raffaele, 20132 Milano, ItalyGastroenterology and Endoscopy IRCCS, Ospedale San Raffaele, 20132 Milano, ItalyGastroenterology and Endoscopy IRCCS, Ospedale San Raffaele, 20132 Milano, ItalyGastroenterology and Endoscopy IRCCS, Ospedale San Raffaele, 20132 Milano, ItalyGastroenterology and Endoscopy IRCCS, Ospedale San Raffaele, 20132 Milano, ItalyGastroenterology and Endoscopy IRCCS, Ospedale San Raffaele, 20132 Milano, ItalyDepartment of Gastroenterology, INFINY Institute, INSERM NGERE, CHRU Nancy, F-54500 Vandœuvre-lès-Nancy, FranceGastroenterology and Endoscopy IRCCS, Ospedale San Raffaele, 20132 Milano, ItalyGastroenterology and Endoscopy IRCCS, Ospedale San Raffaele, 20132 Milano, ItalyAcute severe ulcerative colitis (ASUC) often requires surgical intervention, such as proctocolectomy with ileal pouch–anal anastomosis (IPAA). While IPAA improves patient outcomes, it can be associated with pouchitis, a common and debilitating complication characterized by inflammation of the pouch. The development of pouchitis is closely linked to dysbiosis—an imbalance in the gut microbiota. Understanding the role of the microbiota in pouch health has spurred interest in probiotics as a therapeutic strategy. Probiotics represent a promising avenue in the management of pouchitis, offering a natural and targeted approach to improving outcomes for UC patients. This review explores the role of probiotics in the management of UC patients, with a specific focus on preventing and treating pouchitis. We compare the microbiota of healthy pouches to those with pouchitis, highlighting key microbial shifts linked to disease onset and discussing the growing evidence for probiotics as a prevention and therapeutic approach. Future directions should prioritize advancing research to optimize probiotic therapies and establish personalized approaches based on individual microbiome profiles, highlighting their significant potential as a promising treatment strategy for pouchitis.https://www.mdpi.com/2076-2607/13/1/19pouchitispouchulcerative colitisprobioticsmicrobiotaIBD |
| spellingShingle | Francesca Bernardi Fabrizio Fanizzi Tommaso Lorenzo Parigi Alessandra Zilli Mariangela Allocca Federica Furfaro Laurent Peyrin-Biroulet Silvio Danese Ferdinando D’Amico Role of Probiotics in the Management of Patients with Ulcerative Colitis and Pouchitis Microorganisms pouchitis pouch ulcerative colitis probiotics microbiota IBD |
| title | Role of Probiotics in the Management of Patients with Ulcerative Colitis and Pouchitis |
| title_full | Role of Probiotics in the Management of Patients with Ulcerative Colitis and Pouchitis |
| title_fullStr | Role of Probiotics in the Management of Patients with Ulcerative Colitis and Pouchitis |
| title_full_unstemmed | Role of Probiotics in the Management of Patients with Ulcerative Colitis and Pouchitis |
| title_short | Role of Probiotics in the Management of Patients with Ulcerative Colitis and Pouchitis |
| title_sort | role of probiotics in the management of patients with ulcerative colitis and pouchitis |
| topic | pouchitis pouch ulcerative colitis probiotics microbiota IBD |
| url | https://www.mdpi.com/2076-2607/13/1/19 |
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