Live fast, die fast principle in a single cell of fission yeast
Growth and death are both fundamental macroscopic properties for all living matters, and thus cell division and mortality rates are good parameters for characterizing cellular physiology in a given environment. While population growth rates in various conditions have been reported in literature, dea...
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Shared Science Publishers OG
2017-08-01
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| Series: | Microbial Cell |
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| Online Access: | http://microbialcell.com/researcharticles/live-fast-die-fast-principle-in-a-single-cell-of-fission-yeast/ |
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| author | Hidenori Nakaoka |
| author_facet | Hidenori Nakaoka |
| author_sort | Hidenori Nakaoka |
| collection | DOAJ |
| description | Growth and death are both fundamental macroscopic properties for all living matters, and thus cell division and mortality rates are good parameters for characterizing cellular physiology in a given environment. While population growth rates in various conditions have been reported in literature, death rate is rarely measured, especially in favorable culture conditions where cells grow exponentially. In our recent study (Nakaoka and Wakamoto, 2017), we developed a microfluidics-based platform to track multiple single cell lineages until death. The system enabled us to monitor both cell growth and death in controlled steady environments, and we confirmed the absence of replicative aging in fission yeast old-pole cell lineages by showing remarkable constancy both in cell division and mortality rates. Furthermore, we revealed a growth-death trade-off relation in non-stressed conditions. The phenomenological law that constrains macroscopic physiological parameters could provide a new quantitative insight into possible balanced-growth states in various environments. |
| format | Article |
| id | doaj-art-9fb3eb7ba66140c9b167b5ff686e5423 |
| institution | DOAJ |
| issn | 2311-2638 |
| language | English |
| publishDate | 2017-08-01 |
| publisher | Shared Science Publishers OG |
| record_format | Article |
| series | Microbial Cell |
| spelling | doaj-art-9fb3eb7ba66140c9b167b5ff686e54232025-08-20T02:57:39ZengShared Science Publishers OGMicrobial Cell2311-26382017-08-014930831010.15698/mic2017.09.591Live fast, die fast principle in a single cell of fission yeastHidenori Nakaoka0Department of Basic Science, Graduate School of Arts and Sciences, The University of Tokyo.Growth and death are both fundamental macroscopic properties for all living matters, and thus cell division and mortality rates are good parameters for characterizing cellular physiology in a given environment. While population growth rates in various conditions have been reported in literature, death rate is rarely measured, especially in favorable culture conditions where cells grow exponentially. In our recent study (Nakaoka and Wakamoto, 2017), we developed a microfluidics-based platform to track multiple single cell lineages until death. The system enabled us to monitor both cell growth and death in controlled steady environments, and we confirmed the absence of replicative aging in fission yeast old-pole cell lineages by showing remarkable constancy both in cell division and mortality rates. Furthermore, we revealed a growth-death trade-off relation in non-stressed conditions. The phenomenological law that constrains macroscopic physiological parameters could provide a new quantitative insight into possible balanced-growth states in various environments.http://microbialcell.com/researcharticles/live-fast-die-fast-principle-in-a-single-cell-of-fission-yeast/macroscopic phenomenologygrowthdeathagingprotein aggregationmicrofluidicsfission yeast |
| spellingShingle | Hidenori Nakaoka Live fast, die fast principle in a single cell of fission yeast Microbial Cell macroscopic phenomenology growth death aging protein aggregation microfluidics fission yeast |
| title | Live fast, die fast principle in a single cell of fission yeast |
| title_full | Live fast, die fast principle in a single cell of fission yeast |
| title_fullStr | Live fast, die fast principle in a single cell of fission yeast |
| title_full_unstemmed | Live fast, die fast principle in a single cell of fission yeast |
| title_short | Live fast, die fast principle in a single cell of fission yeast |
| title_sort | live fast die fast principle in a single cell of fission yeast |
| topic | macroscopic phenomenology growth death aging protein aggregation microfluidics fission yeast |
| url | http://microbialcell.com/researcharticles/live-fast-die-fast-principle-in-a-single-cell-of-fission-yeast/ |
| work_keys_str_mv | AT hidenorinakaoka livefastdiefastprincipleinasinglecelloffissionyeast |