Neuromorphic deviations associated with transcriptomic expression and specific cell type in Alzheimer’s disease
Abstract Alzheimer’s disease (AD) is known to be associated with cortical anatomical atrophy and neurodegeneration across various brain regions. However, the relationships between brain structural changes in AD and gene expression remain unclear. We perform the morphometric similarity network (MSN)...
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Nature Portfolio
2025-03-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-90872-w |
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| author | Jinzhong Peng Qin Tang Yilu Li Lin Liu Bharat Bhusan Biswal Pan Wang |
| author_facet | Jinzhong Peng Qin Tang Yilu Li Lin Liu Bharat Bhusan Biswal Pan Wang |
| author_sort | Jinzhong Peng |
| collection | DOAJ |
| description | Abstract Alzheimer’s disease (AD) is known to be associated with cortical anatomical atrophy and neurodegeneration across various brain regions. However, the relationships between brain structural changes in AD and gene expression remain unclear. We perform the morphometric similarity network (MSN) analysis to reveal the consistent cortical structural differences in individuals with AD compared to controls, and investigate the associations between brain-wide gene expression and morphometric changes. Furthermore, we identify abnormally MSN-related genes linked to specific cell types as the major contributors to transcriptomic relationships. MSN-related structural changes are located in the lateral ventral prefrontal cortex, temporal pole and medial prefrontal lobe, which are highly associated with the AD’s cognitive decline. Analysis of gene expression shows the spatial correlations between AD-related genes and MSN differences. Examination of cell type-specific signature genes indicates that changes in microglia and neuronal transcriptional profiles largely contribute to AD-specific MSN differences. The study map the disease-specific structural alterations in AD down to the cellular level, offering a novel perspective on the linking surface-level changes to molecular mechanisms. |
| format | Article |
| id | doaj-art-9fb2aec58bd04670ad450d2fdd70946a |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-9fb2aec58bd04670ad450d2fdd70946a2025-08-20T02:59:20ZengNature PortfolioScientific Reports2045-23222025-03-0115111110.1038/s41598-025-90872-wNeuromorphic deviations associated with transcriptomic expression and specific cell type in Alzheimer’s diseaseJinzhong Peng0Qin Tang1Yilu Li2Lin Liu3Bharat Bhusan Biswal4Pan Wang5The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of ChinaThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of ChinaThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of ChinaThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of ChinaThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of ChinaThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of ChinaAbstract Alzheimer’s disease (AD) is known to be associated with cortical anatomical atrophy and neurodegeneration across various brain regions. However, the relationships between brain structural changes in AD and gene expression remain unclear. We perform the morphometric similarity network (MSN) analysis to reveal the consistent cortical structural differences in individuals with AD compared to controls, and investigate the associations between brain-wide gene expression and morphometric changes. Furthermore, we identify abnormally MSN-related genes linked to specific cell types as the major contributors to transcriptomic relationships. MSN-related structural changes are located in the lateral ventral prefrontal cortex, temporal pole and medial prefrontal lobe, which are highly associated with the AD’s cognitive decline. Analysis of gene expression shows the spatial correlations between AD-related genes and MSN differences. Examination of cell type-specific signature genes indicates that changes in microglia and neuronal transcriptional profiles largely contribute to AD-specific MSN differences. The study map the disease-specific structural alterations in AD down to the cellular level, offering a novel perspective on the linking surface-level changes to molecular mechanisms.https://doi.org/10.1038/s41598-025-90872-wAlzheimer’s diseaseCognitive declineCell typesMorphometric similarity networkGene expression |
| spellingShingle | Jinzhong Peng Qin Tang Yilu Li Lin Liu Bharat Bhusan Biswal Pan Wang Neuromorphic deviations associated with transcriptomic expression and specific cell type in Alzheimer’s disease Scientific Reports Alzheimer’s disease Cognitive decline Cell types Morphometric similarity network Gene expression |
| title | Neuromorphic deviations associated with transcriptomic expression and specific cell type in Alzheimer’s disease |
| title_full | Neuromorphic deviations associated with transcriptomic expression and specific cell type in Alzheimer’s disease |
| title_fullStr | Neuromorphic deviations associated with transcriptomic expression and specific cell type in Alzheimer’s disease |
| title_full_unstemmed | Neuromorphic deviations associated with transcriptomic expression and specific cell type in Alzheimer’s disease |
| title_short | Neuromorphic deviations associated with transcriptomic expression and specific cell type in Alzheimer’s disease |
| title_sort | neuromorphic deviations associated with transcriptomic expression and specific cell type in alzheimer s disease |
| topic | Alzheimer’s disease Cognitive decline Cell types Morphometric similarity network Gene expression |
| url | https://doi.org/10.1038/s41598-025-90872-w |
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