A Case Report with Severe Thrombocytopenia Induced by Axitinib
Axitinib is an oral, second-generation tyrosine kinase inhibitor that is selective for vascular endothelial growth factor receptors (VEGFR). This agent is approved as monotherapy or in combination with immune checkpoint inhibitors for the treatment of metastatic renal cell carcinoma. Axitinib is ass...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2020/7520783 |
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| author | Ulkuhan I. Koksal Janeiro Valle Goffin Brian Lewis Oliver A. Sartor Elizaveta Belyaeva Francisco Socola Pedro C. Barata |
| author_facet | Ulkuhan I. Koksal Janeiro Valle Goffin Brian Lewis Oliver A. Sartor Elizaveta Belyaeva Francisco Socola Pedro C. Barata |
| author_sort | Ulkuhan I. Koksal |
| collection | DOAJ |
| description | Axitinib is an oral, second-generation tyrosine kinase inhibitor that is selective for vascular endothelial growth factor receptors (VEGFR). This agent is approved as monotherapy or in combination with immune checkpoint inhibitors for the treatment of metastatic renal cell carcinoma. Axitinib is associated with a safety profile very similar to other anti-VEGFR inhibitors but usually with fewer hematologic adverse events, due to the selectivity for VEGF. In this report, we presented a rare case of grade 4 axitinib-induced thrombocytopenia, not observed with other antiangiogenic therapies. We discuss the differential diagnostic work-up, the necessary multidisciplinary approach, and the successful management of the case. |
| format | Article |
| id | doaj-art-9fa7166197724943bfc39e13b60afd77 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-9fa7166197724943bfc39e13b60afd772025-02-03T06:46:08ZengWileyCase Reports in Hematology2090-65602090-65792020-01-01202010.1155/2020/75207837520783A Case Report with Severe Thrombocytopenia Induced by AxitinibUlkuhan I. Koksal0Janeiro Valle Goffin1Brian Lewis2Oliver A. Sartor3Elizaveta Belyaeva4Francisco Socola5Pedro C. Barata6Tulane Cancer Center, School of Medicine, Tulane University, New Orleans, LA, USATulane Cancer Center, School of Medicine, Tulane University, New Orleans, LA, USATulane Cancer Center, School of Medicine, Tulane University, New Orleans, LA, USATulane Cancer Center, School of Medicine, Tulane University, New Orleans, LA, USATulane Cancer Center, School of Medicine, Tulane University, New Orleans, LA, USATulane Cancer Center, School of Medicine, Tulane University, New Orleans, LA, USATulane Cancer Center, School of Medicine, Tulane University, New Orleans, LA, USAAxitinib is an oral, second-generation tyrosine kinase inhibitor that is selective for vascular endothelial growth factor receptors (VEGFR). This agent is approved as monotherapy or in combination with immune checkpoint inhibitors for the treatment of metastatic renal cell carcinoma. Axitinib is associated with a safety profile very similar to other anti-VEGFR inhibitors but usually with fewer hematologic adverse events, due to the selectivity for VEGF. In this report, we presented a rare case of grade 4 axitinib-induced thrombocytopenia, not observed with other antiangiogenic therapies. We discuss the differential diagnostic work-up, the necessary multidisciplinary approach, and the successful management of the case.http://dx.doi.org/10.1155/2020/7520783 |
| spellingShingle | Ulkuhan I. Koksal Janeiro Valle Goffin Brian Lewis Oliver A. Sartor Elizaveta Belyaeva Francisco Socola Pedro C. Barata A Case Report with Severe Thrombocytopenia Induced by Axitinib Case Reports in Hematology |
| title | A Case Report with Severe Thrombocytopenia Induced by Axitinib |
| title_full | A Case Report with Severe Thrombocytopenia Induced by Axitinib |
| title_fullStr | A Case Report with Severe Thrombocytopenia Induced by Axitinib |
| title_full_unstemmed | A Case Report with Severe Thrombocytopenia Induced by Axitinib |
| title_short | A Case Report with Severe Thrombocytopenia Induced by Axitinib |
| title_sort | case report with severe thrombocytopenia induced by axitinib |
| url | http://dx.doi.org/10.1155/2020/7520783 |
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