HETEROTOPIC TRANSPLANTATION OF HEART AND THE REGULATORY MECHANISMS OF THE ADAPTATION
Aim. The article describes the results of an experimental study of the adaptation mechanisms of heart and transplant (cardio-pulmonary complex, CPC) in heterotopic transplantation.Materials and methods. CPC`s from recipients (8 dogs) were transplanted in left oblique-diaphragmatic sinus of donor`s (...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Siberian State Medical University (Tomsk)
2016-06-01
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| Series: | Бюллетень сибирской медицины |
| Subjects: | |
| Online Access: | https://bulletin.ssmu.ru/jour/article/view/594 |
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| Summary: | Aim. The article describes the results of an experimental study of the adaptation mechanisms of heart and transplant (cardio-pulmonary complex, CPC) in heterotopic transplantation.Materials and methods. CPC`s from recipients (8 dogs) were transplanted in left oblique-diaphragmatic sinus of donor`s (8 dogs). As a results of parallel connection transplant pre- and post-load of donor`s heart was reduces. Oxygenated blood by CPC was passed the left chambers of donor`s heart and returned to the aorta. Another part from pulmonary artery shunted to the right chamber of CPC as a result decreased systolic pressure on the right ventricle of heart. During the co-working of CPC and heart was happened synchronization.Consequently self-regulating process of circulatory system provides mechanism of adaptation in new conditions. The findings are important for understanding the effectiveness and relevance of this bilogical method of circulatory support. |
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| ISSN: | 1682-0363 1819-3684 |