Analysis of p53-Independent Functions of the Mdm2-MdmX Complex Using Data-Independent Acquisition-Based Profiling

Analysis of p53-Independent Functions of the Mdm2-MdmX Complex Using Data-Independent Acquisition-Based Profiling

Background: We utilized data-independent acquisition (DIA) to study the poorly understood biology of Mdm2 and MdmX in a p53-null context. Mdm2 and MdmX form an E3-ligase complex that has as its most well-studied function the negative regulation of the tumor suppressor p53; however, it is also known...

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Bibliographic Details
Main Authors: Anu Jain, Rafaela Muniz de Queiroz, Jayanta K. Chakrabarty, Karl A. T. Makepeace, Carol Prives, Lewis M. Brown
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Proteomes
Subjects:
data-independent acquisition
label-free proteomics
Mdm2
MdmX
p53-independent functions
cancer
Online Access:https://www.mdpi.com/2227-7382/13/2/18
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