Lack of junctional adhesion molecule (JAM)-B traps CD8 T cells in CNS border zones and ameliorates autoimmune neuroinflammation

Lack of junctional adhesion molecule (JAM)-B traps CD8 T cells in CNS border zones and ameliorates autoimmune neuroinflammation

Abstract The endothelial blood-brain barrier (BBB) tightly controls T cell entry into the central nervous system (CNS). T cell extravasation across the BBB involves a multi-step cascade with a predominant role of α4β1-integrins. In contrast to CD4 T cells, α4β1-integrin mediated CD8 T cell interacti...

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Main Authors: Javier Pareja, Sidar Aydin, Mara Zbinden, Elisa Bouillet, Niklas Zollinger, Vidusiya Theivendram, Amal Fahmi, Petr Pleskač, Sara Barcos, Felix Paas, Florencia Kloster, Aida Muñoz Blázquez, Nicolas Fonta, Doron Merkler, Urban Deutsch, Britta Engelhardt
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Acta Neuropathologica Communications
Subjects:
CD8 T cell
CNS
BBB
JAM-B
Glia limitans
Neuroinflammation
Online Access:https://doi.org/10.1186/s40478-025-02021-z
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