Immune system effectors as biomarkers of prognosis after acute burns in a case-control study
Burns are a global health problem due to frequent complications, which lead to systemic inflammation, acute respiratory distress syndrome, multiorgan dysfunction, and death. Following the initial injury, it has been demonstrated that the immune system plays a key role in early inflammatio...
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Academia.edu Journals
2024-06-01
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| Series: | Academia Biology |
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| author | Alejandro Ferrari Lorena Di Croce Sabrina Saavedra Marisel Hartwig Omar Perrone María Alejandra Guzmán |
| author_facet | Alejandro Ferrari Lorena Di Croce Sabrina Saavedra Marisel Hartwig Omar Perrone María Alejandra Guzmán |
| author_sort | Alejandro Ferrari |
| collection | DOAJ |
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Burns are a global health problem due to frequent complications, which lead to systemic inflammation, acute respiratory distress syndrome, multiorgan dysfunction, and death. Following the initial injury, it has been demonstrated that the immune system plays a key role in early inflammation, tissue regeneration, and the response against pathogens. In this study, the performance of laboratory determinations as biomarkers of prognosis in acute burned patients was evaluated in a retrospective case-control protocol. Laboratory determinations were immunoglobulin G (IgG), immunoglobulin M (IgM), C-reactive protein (CRP), complement C4 protein (C4), total serum protein (TP), albumin, prealbumin, cholesterol (CHOL), pseudocholinesterase activity (CHE), and transferrin. Patients in the deceased group (DG) showed lower initial IgG levels (p < 0.05) than patients in the survivor group (SG), with a negative predictive value (NPV) of 0.86, and this difference persisted during the hospitalization period. Furthermore, DG patients showed a decrease in CHOL and CHE during the hospitalization period (NPV of 0.86), a tendency that was not observed for the SG. Albumin, TP, C4, and transferrin showed lower initial values in DG than the SG, with a strong correlation with the total burned surface area (TBSA). These results indicate that IgG, CHOL, and CHE measurement might provide useful information for medical intervention independently of the TBSA and suggest that the measurement of TBSA-linked parameters might help to estimate the severity of burns more objectively. In this paper, the causes and implications of the alteration of effector molecules of the immune system are discussed. |
| format | Article |
| id | doaj-art-9f95514a0a6c4b6f893a1082ad93eb08 |
| institution | Kabale University |
| issn | 2837-4010 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Academia.edu Journals |
| record_format | Article |
| series | Academia Biology |
| spelling | doaj-art-9f95514a0a6c4b6f893a1082ad93eb082025-02-11T23:54:53ZengAcademia.edu JournalsAcademia Biology2837-40102024-06-012210.20935/AcadBiol6243Immune system effectors as biomarkers of prognosis after acute burns in a case-control studyAlejandro Ferrari0Lorena Di Croce1Sabrina Saavedra2Marisel Hartwig3Omar Perrone4María Alejandra Guzmán5Laboratorio Central, Hospital Municipal de Quemados Dr. Arturo Umberto Illia, Buenos Aires C1424BSD, Argentina.Laboratorio Central, Hospital Municipal de Quemados Dr. Arturo Umberto Illia, Buenos Aires C1424BSD, Argentina.Laboratorio Central, Hospital Municipal de Quemados Dr. Arturo Umberto Illia, Buenos Aires C1424BSD, Argentina.Laboratorio Central, Hospital Municipal de Quemados Dr. Arturo Umberto Illia, Buenos Aires C1424BSD, Argentina.Laboratorio Central, Hospital Municipal de Quemados Dr. Arturo Umberto Illia, Buenos Aires C1424BSD, Argentina.Laboratorio Central, Hospital Municipal de Quemados Dr. Arturo Umberto Illia, Buenos Aires C1424BSD, Argentina. Burns are a global health problem due to frequent complications, which lead to systemic inflammation, acute respiratory distress syndrome, multiorgan dysfunction, and death. Following the initial injury, it has been demonstrated that the immune system plays a key role in early inflammation, tissue regeneration, and the response against pathogens. In this study, the performance of laboratory determinations as biomarkers of prognosis in acute burned patients was evaluated in a retrospective case-control protocol. Laboratory determinations were immunoglobulin G (IgG), immunoglobulin M (IgM), C-reactive protein (CRP), complement C4 protein (C4), total serum protein (TP), albumin, prealbumin, cholesterol (CHOL), pseudocholinesterase activity (CHE), and transferrin. Patients in the deceased group (DG) showed lower initial IgG levels (p < 0.05) than patients in the survivor group (SG), with a negative predictive value (NPV) of 0.86, and this difference persisted during the hospitalization period. Furthermore, DG patients showed a decrease in CHOL and CHE during the hospitalization period (NPV of 0.86), a tendency that was not observed for the SG. Albumin, TP, C4, and transferrin showed lower initial values in DG than the SG, with a strong correlation with the total burned surface area (TBSA). These results indicate that IgG, CHOL, and CHE measurement might provide useful information for medical intervention independently of the TBSA and suggest that the measurement of TBSA-linked parameters might help to estimate the severity of burns more objectively. In this paper, the causes and implications of the alteration of effector molecules of the immune system are discussed.https://www.academia.edu/121568900/Immune_system_effectors_as_biomarkers_of_prognosis_after_acute_burns_in_a_case_control_study |
| spellingShingle | Alejandro Ferrari Lorena Di Croce Sabrina Saavedra Marisel Hartwig Omar Perrone María Alejandra Guzmán Immune system effectors as biomarkers of prognosis after acute burns in a case-control study Academia Biology |
| title | Immune system effectors as biomarkers of prognosis after acute burns in a case-control study |
| title_full | Immune system effectors as biomarkers of prognosis after acute burns in a case-control study |
| title_fullStr | Immune system effectors as biomarkers of prognosis after acute burns in a case-control study |
| title_full_unstemmed | Immune system effectors as biomarkers of prognosis after acute burns in a case-control study |
| title_short | Immune system effectors as biomarkers of prognosis after acute burns in a case-control study |
| title_sort | immune system effectors as biomarkers of prognosis after acute burns in a case control study |
| url | https://www.academia.edu/121568900/Immune_system_effectors_as_biomarkers_of_prognosis_after_acute_burns_in_a_case_control_study |
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